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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Skp1
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Skp1" in MCE Product Catalog:
14
14 Cited Publications
Target:
Research Areas:
SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities [1] .
1
1 Cited Publications
Target:
Research Areas:
SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF) Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCF Met30 [1].
Target:
Research Areas:
NRX-103094 is a Molecular glue and β-catenin/β-TrCP interaction enhancer, with an EC50 of 62 nM for the binding of pSer33/S37A β-catenin peptide to recombinant β-TrCP/Skp1 complex. NRX-103094 shows selectivity for Ser37 phosphorylation-deficient β-catenin, and has no effect on wild-type doubly phosphorylated β-catenin or other β-TrCP substrates. NRX-103094 can be used in research related to colorectal cancer and ovarian endometrioid adenocarcinoma [1] .
Cat. No.: HY-RS12973
Target:
Research Areas:
SKP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SKP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11020
Target:
Research Areas:
Cat. No.: HY-163019
CAS No.: 2189497-60-5
Research Areas:
EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs) [1].
Cat. No.: HY-RS17896
Target:
Research Areas:
Skp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Skp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24365
Target:
Research Areas:
Skp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Skp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-162240
Target:
Research Areas:
SJH1-51B is a SKP1-recruiting BRD4 PROTAC degrader. SJH1-51B binds to SKP1 in the SKP1-FBXO7-CUL1-RBX1 complex, but shows no or weak binding to monomeric SKP1. SJH1-51B induces proteasome- and SKP1-dependent degradation of BRD4, and this degradation process relies on the neddylation modification of Cullin-RING E3 ligase. SJH1-51B induces proteasome-mediated degradation of the short isoform of BRD4 in non-cancer cells, while it induces proteasome-mediated degradation of both the long and short isoforms of BRD4 in breast cancer cells. SJH1-51B can be used for breast cancer research [1].
Cat. No.: HY-P82229
Synonyms: Skp1; EMC19; OCP2; Skp1A; TCEB1L; S-phase kinase-associated protein 1; Cyclin-A/CDK2-associated protein p19; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcr
Cat. No.: HY-P82229A
Synonyms: Skp1; EMC19; OCP2; Skp1A; TCEB1L; S-phase kinase-associated protein 1; Cyclin-A/CDK2-associated protein p19; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcr
Cat. No.: HY-10949R
CAS No.: 67200-34-4
Target:
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SMER3 (Standard) is the analytical standard of SMER3 (HY-10949). This product is intended for research and analytical applications. SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30 [1].
Cat. No.: HY-P76644
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Skp1; Transcription Elongation Factor B Polypeptide 1-Like; Prev. Skp1A; Organ Of Corti Protein 2; TCEB1L; MGC34403; OCP-II; OCP-2; EMC19; SIII; OCP2; RNA Polymerase II Elongation Factor-Like Protein OCP2; P19A; RNA Polymerase II Elongation Factor-Like Pr
Species:
Human
Source:
HEK293
Cat. No.: HY-134203
CAS No.: 634908-46-6
Target:
Research Areas:
SCFSkp2-IN-1 dihydrochloride is a SCFSkp2 E3 ligase inhibitor. SCFSkp2-IN-1 dihydrochloride prevents Skp2 incorporation into the SCFSkp2 complex by disrupting Skp1-Skp2 binding, inhibits p27 ubiquitination, and stabilizes p27, p21, and p57. SCFSkp2-IN-1 dihydrochloride induces autophagy and cell cycle arrest. SCFSkp2-IN-1 dihydrochloride overcomes drug resistance in multiple myeloma models and exhibits synergistic antitumor effects with Bortezomib (HY-10227). SCFSkp2-IN-1 dihydrochloride can be used for research related to multiple myeloma and leukemia [1].
Cat. No.: HY-100237R
CAS No.: 222716-34-9
Research Areas:
SZL P1-41 (Standard) is the analytical standard of SZL P1-41 (HY-100237). This product is intended for research and analytical applications. SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities [1] .
Cat. No.: HY-P703473
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Skp1; Transcription Elongation Factor B Polypeptide 1-Like; Prev. Skp1A; Organ Of Corti Protein 2; TCEB1L; MGC34403; OCP-II; OCP-2; EMC19; SIII; OCP2; RNA Polymerase II Elongation Factor-Like Protein OCP2; P19A; RNA Polymerase II Elongation Factor-Like Pr
Species:
Human
Source:
E. coli
Cat. No.: HY-P703474
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Skp1; Transcription Elongation Factor B Polypeptide 1-Like; Prev. Skp1A; Organ Of Corti Protein 2; TCEB1L; MGC34403; OCP-II; OCP-2; EMC19; SIII; OCP2; RNA Polymerase II Elongation Factor-Like Protein OCP2; P19A; RNA Polymerase II Elongation Factor-Like Pr
Species:
Human
Source:
E. coli
Cat. No.: HY-L128
184 compounds
Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.
Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).
MCE carefully prepared a unique collection of 184 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
