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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
Subtilisin
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "Subtilisin" in MCE Product Catalog:
Research Areas:
Subtilisin (EC 3.4.21.14) is a bacterial serine protease. Subtilisin induces Apoptosis. Subtilisin stimulates the expression of pro-allergic cytokines (IL-1α, IL-33). Subtilisin induces prototypic allergic lung inflammation. Subtilisin exhibits anticancer activity against breast and colon cancer. Subtilisin shows antifouling activity. Subtilisin can be used as a detergent additive .
7
7 Publications Verification
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PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34 .
7
7 Publications Verification
Cat. No.: HY-120088
CAS No.: 1632250-49-7
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PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region .
5
5 Cited Publications
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SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism .
2
2 Cited Publications
Cat. No.: HY-P78747
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FURIN; Subtilisin-Like Proprotein Convertase 1; Prev. PCSK3; Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein); Prev. PACE; Furin (Paired Basic Amino Acid Cleaving Enzyme); Prev. FUR; Proprotein Convertase Subtilisin/Kexin Type 3; Paired Basic Amino Acid Residue-Cleaving Enzyme; Furin, Membrane Associated Receptor Protein; Furin; Dibasic Processing Enzyme; SPC1; FES Upstream Region; Proprotein Convertase Subtilisin/Kexin 3; Furin, Paired Basic Amino Acid Cleaving Enzyme; Dibasic-Processing Enzyme
Species:
Human
Source:
HEK293
1
1 Cited Publications
Target:
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SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1 .
1
1 Cited Publications
Cat. No.: HY-P70545A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PCSK9; PC9; Prev. HCHOLA3; Hypercholesterolemia, Autosomal Dominant 3; NARC-1; Neural Apoptosis Regulated Convertase 1; Subtilisin/Kexin-Like Protease PC9; Neural Apoptosis-Regulated Convertase 1; FH3; LDLCQ1; Proprotein Convertase 9; FHCL3; NARC1; Proprotein Convertase Subtilisin/Kexin Type 9; Convertase Subtilisin/Kexin Type 9 Preproprotein
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P73340
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PCSK9; PC9; Prev. HCHOLA3; Hypercholesterolemia, Autosomal Dominant 3; NARC-1; Neural Apoptosis Regulated Convertase 1; Subtilisin/Kexin-Like Protease PC9; Neural Apoptosis-Regulated Convertase 1; FH3; LDLCQ1; Proprotein Convertase 9; FHCL3; NARC1; Propro
Species:
Rat
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P73728
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCSK9; PC9; Prev. HCHOLA3; Hypercholesterolemia, Autosomal Dominant 3; NARC-1; Neural Apoptosis Regulated Convertase 1; Subtilisin/Kexin-Like Protease PC9; Neural Apoptosis-Regulated Convertase 1; FH3; LDLCQ1; Proprotein Convertase 9; FHCL3; NARC1; Propro
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71189A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PCSK9; PC9; Prev. HCHOLA3; Hypercholesterolemia, Autosomal Dominant 3; NARC-1; Neural Apoptosis Regulated Convertase 1; Subtilisin/Kexin-Like Protease PC9; Neural Apoptosis-Regulated Convertase 1; FH3; LDLCQ1; Proprotein Convertase 9; FHCL3; NARC1; Propro
Species:
Mouse
Source:
HEK293
Target:
Research Areas:
Subtilisin, bacillus licheniformis (Bacillopeptidaseb) is a serine endopeptidase that cleaves peptide bonds with broad substrate specificity. Subtilisin, bacillus licheniformis exhibits P1 site preference (the first residue at the N-terminus of the cleavage site). Subtilisin, bacillus licheniformis can be used in protein hydrolysis, detergents, proteomics, and other fields .
Cat. No.: HY-148687A
Purity: 93.97%
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SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sodium sequence: 5′-TGmCTACAAAACmCmCA-3′ .
Cat. No.: HY-P4517
CAS No.: 108318-36-1
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Cat. No.: HY-P4516
CAS No.: 104634-10-8
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PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse .
Cat. No.: HY-P4582
CAS No.: 110906-89-3
Synonyms: Suc-FAAF-pNA
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Cat. No.: HY-P5062A
Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA
Target:
Research Areas:
DEC-RVRK-CMK TFA (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK TFA is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK TFA inhibits PC4-mediated proteolysis with an IC50 of 12.2 nM in rats. DEC-RVRK-CMK TFA holds promise for antiviral infection-related research .
Cat. No.: HY-P3947
CAS No.: 147471-56-5
Target:
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Cat. No.: HY-148687
Target:
Research Areas:
SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .
Cat. No.: HY-P5062
CAS No.: 534615-50-4
Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
Target:
Research Areas:
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK inhibits PC4-mediated proteolysis with an IC50 of 12.2 nM in rats. DEC-RVRK-CMK holds promise for antiviral infection-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
