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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
55 Results for "
TCA cycle
" in MedChemExpress (MCE) Product Catalog:
Products (55)
55 Results for "TCA cycle" in MCE Product Catalog:
12
12 Cited Publications
Synonyms: 6PPD-Quinone
Category:
Alkaloids Quinones Other Alkaloids Other Diseases Benzene Quinones Endogenous metabolite Disease Research Fields
Target:
11
Target:
8
8 Cited Publications
Synonyms: Acetyl-CoA trisodium
8
8 Cited Publications
Synonyms: Acetyl-CoA lithium
3
2
2 Cited Publications
Cat. No.: HY-B0831
CAS No.: 69327-76-0
Research Areas:
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .
1
Category:
1
1 Cited Publications
Cat. No.: HY-W012985
CAS No.: 600-22-6
Target:
Research Areas:
Methyl pyruvate is a p53/p21 axis inhibitor, intrinsic apoptosis inhibitor, cytotoxic agent, ATP production enhancer, proteasome function restorer, TDP-43 localization normalizer, ATP-sensitive potassium (K +ATP) channel inhibitor, depolarizer, and insulin secretagogue .Methyl pyruvate turns off apoptotic pathways, induces cancer cell death, acts as a substrate for dimeric dihydrodiol dehydrogenase, enhances TCA cycle activity, rescues proteasome impairment and TDP-43 mislocalization, inhibits K +ATP channels independent of ATP, depolarizes pancreatic β-cell membranes, modulates insulin secretion, and enters pancreatic β-cell mitochondria via a specific transporter .Methyl pyruvate can be used for the research of lung adenocarcinoma, ovarian clear cell adenocarcinoma, breast adenocarcinoma, amyotrophic lateral sclerosis, and type II diabetes .
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Acyl coenzyme A synthetase (ACS), namely acetyl coenzyme A synthetase, is often used in biochemical research. Acyl coenzyme A synthetase can catalyze the activation of fatty acids by coenzyme A through a two-step thioesterification reaction to produce acyl coenzyme A, and then participate in a variety of anabolic and catabolic lipid metabolism pathways, and participate in the TCA cycle in aerobic respiration .
Cat. No.: HY-114293A
CAS No.: 75520-41-1
Synonyms: Acetyl-CoA trilithium
Cat. No.: HY-114293S
Purity: 97.40%
Synonyms: Acetyl-CoA-13C2 lithium
Research Areas:
Acetyl coenzyme A- 13C2 lithium is the 13C-labeled Acetyl coenzyme A (HY-114293). Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis .
Cat. No.: HY-148837
CAS No.: 2883535-99-5
Target:
PROTACs c-Myc CD276/B7-H3 IAP Casein Kinase Eukaryotic Release Factor (eRF) Oxidative Phosphorylation Apoptosis
Research Areas:
GT19630 is an orally active c-Myc PROTAC targeted degrader based on the cereblon E3 ubiquitin ligase, with an IC50 of 1.5 nM against human c-Myc. GT19630 mediates the degradation of MYC, GSPT1, GSPT2, CK1 alpha, N-Myc, B7-H3 and XIAP, and disrupts the MYC-GSPT1 synergistic regulatory feedback loop. GT19630 inhibits cell proliferation, blocks S-phase progression of the cell cycle, promotes cell apoptosis, reduces cell migration capacity, induces integrated stress response, and blocks oxidative phosphorylation by inhibiting the TCA cycle. GT19630 can be used in the research of Myc-driven hematological cancers, small cell lung cancer, breast cancer, TP53-mutant cancers, and venetoclax-resistant cancers .
Cat. No.: HY-115840
CAS No.: 936498-64-5
ICL-CCIC-0019 is a CHKA inhibitor with a human IC50 of 270 nM. ICL-CCIC-0019 blocks choline phosphorylation and phosphatidylcholine synthesis via the CDP-choline pathway. ICL-CCIC-0019 inhibits choline uptake, mitochondrial respiration, TCA cycle flux, de novo fatty acid synthesis, and mitochondrial membrane potential, while inducing G1 phase arrest, ER stress, caspase-dependent apoptosis, AMPK activation, glycolysis, acetate uptake, and mitochondrial network disruption. ICL-CCIC-0019 can be used for cancer research .
Cat. No.: HY-160237
CAS No.: 2426547-83-1
Target:
Anaplastic lymphoma kinase (ALK) Glutaminase ATP Synthase Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
HYL001 is an orally active, selective ALK4/ALK5 inhibitor with Kd values of 13 nM and 22.5 nM for ALK4 and ALK5, respectively. HYL001 inhibits GLS expression. HYL001 impairs glutamine metabolism, mitochondrial respiration, the TCA cycle, oxidative phosphorylation, ATP production, and redox balance, while selectively targeting mitochondria, disrupting mitochondrial structure, and inducing Apoptosis and ROS. HYL001 inhibits tumor growth and liver metastasis. HYL001 can be used in research on breast cancer, hepatocellular carcinoma, and microsatellite-stable colorectal cancer metastasis .
Cat. No.: HY-Y0836S
CAS No.: 1628796-56-4
Synonyms: 1,4-Diethyl butanedioate-1,2,3,4-13C4
Cat. No.: HY-114333
CAS No.: 876150-14-0
Synonyms: 1-Octyl 2-oxopentanedioate
Target:
Research Areas:
Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD .
Cat. No.: HY-114293S5
CAS No.: 121443-44-5
Synonyms: Acetyl-CoA-d3
Research Areas:
Acetyl coenzyme A-d3 (Acetyl-CoA-d3) is the deuterium labeled Acetyl coenzyme A (HY-114293). Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis .
Cat. No.: HY-N6663
CAS No.: 13466-78-9
Cat. No.: HY-W283726
CAS No.: 141-95-7
Research Areas:
Sodium malonate is an inhibitor of succinate dehydrogenase (SDH) and can interfere with the TCA cycle. Sodium malonate can act as an AcrAB‑TolC efflux pump inhibitor, blocking multidrug efflux processes in bacteria and enhancing the efficacy of antibiotics. Sodium malonate can be converted to malonyl‑CoA, which mediates protein lysine malonylation, relieves the transcriptional repression effect of STAT6, upregulates TCF1 protein expression, and thereby promotes CD8 + T cell memory differentiation. Sodium malonate can stimulate ovarian steroidogenesis in immature rats, increasing ovarian and uterine weights and ovarian cholesterol production. Sodium malonate can inhibit brain ATP production, leading to energy deficiency, neuronal glutamate accumulation, and excitotoxic striatal lesions. Sodium malonate can be used in research on metabolism-related diseases, immune-related diseases, and bacterial infections, and can also serve as an intermediate for research related to organic synthesis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
