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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
TolC
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "TolC" in MCE Product Catalog:
Cat. No.: HY-124819
CAS No.: 957471-96-4
D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively . D13-9001 exhibits antibiotic activities .
Cat. No.: HY-W283726
CAS No.: 141-95-7
Research Areas:
Sodium malonate is an inhibitor of succinate dehydrogenase (SDH) and can interfere with the TCA cycle. Sodium malonate can act as an AcrAB‑TolC efflux pump inhibitor, blocking multidrug efflux processes in bacteria and enhancing the efficacy of antibiotics. Sodium malonate can be converted to malonyl‑CoA, which mediates protein lysine malonylation, relieves the transcriptional repression effect of STAT6, upregulates TCF1 protein expression, and thereby promotes CD8 + T cell memory differentiation. Sodium malonate can stimulate ovarian steroidogenesis in immature rats, increasing ovarian and uterine weights and ovarian cholesterol production. Sodium malonate can inhibit brain ATP production, leading to energy deficiency, neuronal glutamate accumulation, and excitotoxic striatal lesions. Sodium malonate can be used in research on metabolism-related diseases, immune-related diseases, and bacterial infections, and can also serve as an intermediate for research related to organic synthesis .
BDM91270 (compound 29) is an E. coli AcrAB-TolC efflux pump inhibitor with an EC90 of 0.6 μM for wild-type E. coli AcrB. BDM91270 can be used in the study of Escherichia coli drug resistance .
Cat. No.: HY-101444
CAS No.: 115871-02-8
MC-207110 is a broad-spectrum efflux pump inhibitor. MC-207110 is active against all three known Mex efflux pumps from P. aeruginosa and their close Escherichia coli efflux pump homolog (AcrAB-TolC). MC-207110 can decrease the intrinsic resistance of P. aeruginosa to fluoroquinolones. MC-207110 can be used for the research of infection .
Cat. No.: HY-119172R
CAS No.: 70-09-7
Target:
Research Areas:
NSC-60339 (Standard) is the analytical standard of NSC-60339. This product is intended for research and analytical applications. NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent .
Cat. No.: HY-146078
CAS No.: 2579696-45-8
Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
