7

Mevociclib

7 Publications Verification

Cat. No.: HY-128587

CAS No.: 1816989-16-8

Purity: 98.02%

Synonyms: SY-1365

Target:

CDK

Research Areas:

Cancer

Mevociclib (SY-1365) is a potent and first-in-class selective CDK7 inhibitor, with a K_i of 17.4 nM. Mevociclib exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. Mevociclib possesses anti-tumor activity in hematological and multiple aggressive solid tumors .

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2

4A3-SC8

2 Cited Publications

Cat. No.: HY-148559

CAS No.: 1857340-78-3

Purity: 99.21%

Target:

Liposome

Research Areas:

Cancer

4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model .

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1

UPGL00004

1 Cited Publications

Cat. No.: HY-119377

CAS No.: 1890169-95-5

Purity: ≥98.0%

Target:

Glutaminase

Research Areas:

Cancer

UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC₅₀=29 nM; K_d=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines .

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PI-55

Cat. No.: HY-141519

CAS No.: 1122579-42-3

Purity: 98.89%

Target:

Parasite

Research Areas:

Infection

PI-55 is a specific cytokinin receptor inhibitor. PI-55 is structurally related to 6-benzylaminopurine (BAP) and was shown to inhibit competitively BAP binding on Arabidopsis-specific receptors CRE1/AHK4 and AHK3. PI-55 inhibits cytokinins induced haustorium formation and increased parasite aggressiveness .

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Hexadecanal

Cat. No.: HY-W004305

CAS No.: 629-80-1

Synonyms: Palmitaldehyde

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Hexadecanal (Palmitaldehyde) , a volatile long-chain aliphatic aldehyde, is emitted from human feces, skin, and breath. The receptor for hexadecanal(OR37B) is highly conserved across mammals. Hexadecanal may exert its effects by modulating functional connectivity between the brain substrates of social appraisal and the brain substrates of aggressive execution. Also, Hexadecanal is confirmed to be highly deterrent to the ant Lasius niger. Hexadecanal is promising for the research of startle responses and aggression

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Azaperone

Cat. No.: HY-B1470

CAS No.: 1649-18-9

Synonyms: R-1929

Target:

Dopamine Receptor Adrenergic Receptor

Research Areas:

Neurological Disease

Azaperone is an antagonist of dopamine D2 receptor (Dopamine D2 Receptor) and α-adrenergic receptor (AR). Azaperone reduces vasomotor tone, mean arterial pressure, hematocrit, hemoglobin concentration, and etorphine-induced duration; induces transient tachycardia followed by bradycardia, splenic uptake of red blood cells, and sedation; alters animal behaviors; and produces sedation with distinct onset and duration in foals. Azaperone is used for sedation and tranquilization in various animals to reduce stress and aggressive behaviors, and serves as a preanesthetic agent .

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CP94253 hydrochloride

Cat. No.: HY-103151

CAS No.: 845861-39-4

Purity: 98.84%

Target:

5-HT Receptor

Research Areas:

Neurological Disease Metabolic Disease

CP94253 hydrochloride is an orally active, brain-penetrant and selective 5-HT_1B receptor agonist with an K_i of 2 nM. CP94253 hydrochloride induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 hydrochloride can be used for the research of depression and heightened aggressive behavior .

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Evenamide

Cat. No.: HY-17612

CAS No.: 1092977-61-1

Synonyms: NW-3509

Target:

Sodium Channel

Research Areas:

Neurological Disease

Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker (K_i=0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness .

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XP-524

Cat. No.: HY-147008

CAS No.: 2344825-52-9

Purity: 99.66%

Target:

Histone Acetyltransferase Epigenetic Reader Domain

Research Areas:

Cancer

XP-524 is a potent BET and EP300 inhibitor. XP-524 shows great tumoricidal activity in vivo. XP-524 prevents KRAS-induced, neoplastic transformation in vivo and extends survival in two transgenic mouse models of aggressive PDAC. XP-524 also enhances the presentation of self-peptide and tumor recruitment of cytotoxic T lymphocytes. XP-524 has the potential for the research of pancreatic ductal adenocarcinoma (PDAC) .

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Lauflumide

Cat. No.: HY-111178

CAS No.: 90280-13-0

Purity: 99.18%

Synonyms: BisfluoroModafinil; CRL-40940; NLS-4

Target:

Dopamine Transporter

Research Areas:

Neurological Disease

Lauflumide (BisfluoroModafinil) is a selective dopamine reuptake inhibitor and wake-promoting agent. Lauflumide inhibits the dopamine transporter (DAT). Lauflumide induces sustained wakefulness without eliciting hyperlocomotion, stereotypy or abnormal behaviors in Mus musculus (house mice). Lauflumide reduces non-rapid eye movement (NREM) sleep rebound in rats, modulates electroencephalogram (EEG) spectral composition, and produces anti-aggressive effects. Lauflumide alleviates circadian rhythm disturbances in rats, increases spontaneous activity in fatigued rats, and facilitates their recovery from severe fatigue. Lauflumide can be used in research related to excessive daytime sleepiness as well as chronic severe fatigue/chronic fatigue syndrome (CFS) .

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Sclareol glycol

Cat. No.: HY-N7007

CAS No.: 55881-96-4

Category:

Natural Products Microorganisms Metabolic Disease Disease Research Fields

Target:

Adenylate Cyclase

Sclareol glycol is a blood-brain barrier-permeable, reversible adenylate cyclase (AC) activator. Sclareol glycol induces dose-dependent changes in body temperature, regulates convulsive seizures and spontaneous activity. Sclareol glycol interacts with GABAergic transmission, thereby affecting dopamine-related behaviors. Sclareol glycol can be used in studies related to convulsive seizures, aggressive responses, thermoregulation, etc .

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Meridianin C

Cat. No.: HY-W107409

CAS No.: 213473-00-8

Category:

Alkaloids Other Alkaloids Marine natural products

Target:

Others

Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .

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HDAC10-IN-1

Cat. No.: HY-144779

CAS No.: 3033417-31-8

Purity: 95.33%

Target:

HDAC Autophagy

Research Areas:

Cancer

HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC₅₀ of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells .

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