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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
amyloid b
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "amyloid b" in MCE Product Catalog:
13
13 Publications Verification
Cat. No.: HY-N0373
CAS No.: 58749-23-8
7
7 Cited Publications
4
4 Cited Publications
Cat. No.: HY-N0044
CAS No.: 52286-59-6
Synonyms: Ginsenoside B2; Panaxoside Re; Sanchinoside Re
Category:
Triterpenes Plant Neurological Disease Terpenoids Panax ginseng C. A. Meyer Extract Endogenous metabolite Disease Research Fields Cancer Araliaceae Extract
Target:
2
2
2 Cited Publications
Cat. No.: HY-P7747
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSB; Keratolytic Winter Erythema (Oudtshoorn Skin Disease); Cathepsin B; Epididymis Secretory Sperm Binding Protein; APP Secretase; amyloid Precursor Protein Secretase; Cathepsin B1; Cysteine Protease; APPS; RECEUP; CPSB; KWE
Species:
Mouse
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P7993A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSB; Keratolytic Winter Erythema (Oudtshoorn Skin Disease); Cathepsin B; Epididymis Secretory Sperm Binding Protein; APP Secretase; amyloid Precursor Protein Secretase; Cathepsin B1; Cysteine Protease; APPS; RECEUP; CPSB; KWE
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P78682
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSB; Keratolytic Winter Erythema (Oudtshoorn Skin Disease); Cathepsin B; Epididymis Secretory Sperm Binding Protein; APP Secretase; amyloid Precursor Protein Secretase; Cathepsin B1; Cysteine Protease; APPS; RECEUP; CPSB; KWE
Species:
Human
Source:
HEK293
Synonyms: Anle138b
Target:
Research Areas:
Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology .
Cat. No.: HY-P2358
CAS No.: 1001405-52-2
Cat. No.: HY-N7046
CAS No.: 142797-34-0
Synonyms: Silibinin B
Cat. No.: HY-N1570
CAS No.: 34175-96-7
Category:
Plant Ketones, Aldehydes, Acids Pteridiaceae Extract Other Families Extract Disease Research Fields Inflammation/Immunology Pteridium aquilinum Extract
Target:
Cat. No.: HY-P99185
CAS No.: 648895-38-9
Synonyms: AAB-001
Target:
Research Areas:
Bapineuzumab (AAB-001) is a humanized IgG1 monoclonal antibody that binds to the N-terminal region of amyloid beta in a helical conformation. Bapineuzumab induces microglial activation by upregulating CD11B, producing pro-inflammatory cytokines (IL-1β and TNFα), clearing plaques, and reducing insoluble and aggregated Aβ. Bapineuzumab can be used for research on Alzheimer's disease .
Cat. No.: HY-P990301
Target:
Research Areas:
Cat. No.: HY-P991046
Target:
Research Areas:
Cat. No.: HY-N1280
CAS No.: 129280-33-7
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Glycyrrhiza uralensis Fisch. Extract Phenols Polyphenols Isoflavones
Target:
Cat. No.: HY-N13742
CAS No.: 219565-74-9
Synonyms: Dihydrohonokiol
Target:
Cat. No.: HY-W117986
CAS No.: 352525-91-8
Research Areas:
Aβ aggregation-IN-1 (Compound 1b) is a β-amyloid aggregation inhibitor/depolymerizer, with IC50 values of 3.92 μM and 7.19 μM, respectively. Aβ aggregation-IN-1 inhibits the activation of preformed β-amyloid fibrils, reactive oxygen species (ROS) and Caspase-3. Aβ aggregation-IN-1 can be used in research related to Alzheimer's disease .
Cat. No.: HY-DY1045
CAS No.: 863918-78-9
Solvent and concentration: DMSO: 5 mg/mL
Cat. No.: HY-151962
CAS No.: 2911640-63-4
Research Areas:
JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable .
Research Areas:
Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
