2 Results for "

anionic region

" in MedChemExpress (MCE) Product Catalog:
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2 Results for "anionic region" in MCE Product Catalog:

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HA2 peptide
HA2 peptide
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Cat. No.: HY-P11353
CAS No.: 117138-19-9
Target:  

Small Interfering RNA (siRNA) HIV

Research Areas:  

Infection Cancer

HA2 peptide is a potent pH-responsive fusion peptide derived from hemagglutinin (HA), corresponding to the N-terminal fusion peptide domain consisting of 23 amino acid residues of HIV-1 gp41 envelope glycoprotein. HA2 peptide adopts a random coil structure under physiological pH conditions; in acidic endosomes, protonation of carboxyl groups reduces negative charge, inducing a transition to an α-helical conformation that can fuse with and destabilize the endosomal membrane. After binding to membranes, the N-terminal and middle regions of HA2 peptide mainly adopt a β-strand conformation, while the C-terminal region remains unstructured. HA2 peptide induces lipid mixing and promotes aqueous content leakage from large unilamellar vesicles whose lipid composition matches that of HIV-1 viruses and target T cells. HA2 peptide is anionic and can bind to cationic peptides to achieve siRNA condensation. HA2 peptide can be used in studies related to cancer and human immunodeficiency virus (HIV) infection .
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1-Decanesulfonic acid
1-Decanesulfonic acid
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Cat. No.: HY-187154
CAS No.: 20283-21-0
Target:  

PAI-1

Research Areas:  

Others

1-Decanesulfonic acid is an alkanesulfonate anionic surfactant that acts as a neutralizer of plasminogen activator inhibitor-1 (PAI-1). 1-Decanesulfonic acid binds to the hydrophobic region in the flexible linker domain of active PAI-1. 1-Decanesulfonic acid induces PAI-1 polymerization via a two-step neutralization mechanism .
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