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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
aromatic interaction
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "aromatic interaction" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: Benzo[def]phenanthrene
Cat. No.: HY-N3057
CAS No.: 18956-15-5
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Chalcones Cajanus cajan (L.) Millsp. Extract Phenols Polyphenols Disease Research Fields Cancer
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Ethoxybenzene is a SARM1 NAD + hydrolase inhibitor (human SARM1 IC50 = 0.385 μM). Ethoxybenzene co-crystallizes with the SARM1 TIR domain and exhibits an edge-to-face aromatic interaction with Trp638. Ethoxybenzene can be used in research on SARM1-related axonal degeneration .
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1,5-Naphthalenedisulfonic acid (Armstrong's acid) is an aromatic disulfonic acid compound commonly used as an intermediate in the dye industry and organic synthesis. 1,5-Naphthalenedisulfonic acid is a pharmaceutical co-former that significantly improves the solubility and thermodynamic stability of poorly soluble drugs. 1,5-Naphthalenedisulfonic acid constructs a stable supramolecular network through coordination, hydrogen bonding, and electrostatic interactions, thereby effectively preventing drug crystallization. 1,5-Naphthalenedisulfonic acid exhibits certain cytotoxicity and antitumor activity in some human hepatoma cells. 1,5-Naphthalenedisulfonic acid can be used for research on human hepatoma .
Cat. No.: HY-W012278
CAS No.: 56-55-3
Synonyms: Tetraphene
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Benz[a]anthracene (Tetraphene) is a polycyclic aromatic hydrocarbon pollutant and also a ligand of aryl hydrocarbon receptor 2 (AHR2), with a pIC50 of 7.319. Benz[a]anthracene can be detected in spruce needles near aluminum smelters. Exposure to Benz[a]anthracene during zebrafish embryonic stage activates the AHR-CYP1A signaling pathway and induces AHR2 expression, leading to social behavioral deficits that persist into adulthood, accompanied by impaired neuro-immune interaction, while anxiety levels remain unaffected. Benz[a]anthracene can be used in studies related to PAH environmental toxicology, developmental neurotoxicity and biodegradation .
Cat. No.: HY-W009071
CAS No.: 211366-30-2
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1,5-Naphthalenedisulfonic acid tetrahydrate is an aromatic disulfonic acid compound commonly used as an intermediate in the dye industry and organic synthesis. 1,5-Naphthalenedisulfonic acid tetrahydrate is a pharmaceutical co-former that significantly improves the solubility and thermodynamic stability of poorly soluble drugs. 1,5-Naphthalenedisulfonic acid tetrahydrate constructs a stable supramolecular network through coordination, hydrogen bonding, and electrostatic interactions, thereby effectively preventing drug crystallization. 1,5-Naphthalenedisulfonic acid tetrahydrate exhibits certain cytotoxicity and antitumor activity in some human hepatoma cells. 1,5-Naphthalenedisulfonic acid tetrahydrate can be used for research on human hepatoma .
Cat. No.: HY-W739372
CAS No.: 25704-18-1
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Poly (sodium 4-styrenesulfonate) is an anionic cation-exchange polyelectrolyte and metal ion binding/retention agent. It selectively retains Cr III and Fe II under pH 1 conditions, and its retention effect on all tested metal ions is enhanced under higher pH conditions. Poly (sodium 4-styrenesulfonate) inhibits nanosheet aggregation through edge-face interactions between aromatic rings and the graphite surface, thereby stabilizing the dispersion of reduced graphene oxide nanosheets. When incorporated into the mixed Nafion coating of bismuth film electrodes, Poly (sodium 4-styrenesulfonate) improves the reproducibility, stability, sensitivity, and anti-fouling capability for trace metal detection .
Cat. No.: HY-P2788
CAS No.: 2493080-84-3
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Cat. No.: HY-103609R
CAS No.: 129-00-0
Synonyms: Benzo[def]phenanthrene (Standard)
Cat. No.: HY-D0910
CAS No.: 102185-48-8
Cat. No.: HY-N3057R
CAS No.: 18956-15-5
Cat. No.: HY-155817
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UNC7096 (compound 53) is a biotinylated affinity reagent. The phenyl ring of UNC7096 replaces the pyrimidine ring in UNC6934 (HY-145103) and introduces biotin at the para position of the phenyl ring, which has a high binding affinity to the NSD2-PWWP1 domain (Kd=46 nM). UNC7096 blocks the interaction between NSD2-PWWP1 and nucleosomal H3K36me2 by occupying the methyl-lysine binding pocket of NSD2-PWWP1. This binding is achieved by covalent binding through the formation of hydrogen bonds and a specific aromatic cage structure. UNC7096 can be used to capture proteins that interact with the NSD2-PWWP1 domain to further analyze the biological significance of these interactions .
Cat. No.: HY-W012278S
CAS No.: 1718-53-2
Synonyms: Tetraphene-d12
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Benz[a]anthracene-d12 (Tetraphene-d12) is the deuterated-labeled Benz[a]anthracene (HY-W012278). Benz[a]anthracene (Tetraphene) is a polycyclic aromatic hydrocarbon pollutant and also a ligand of aryl hydrocarbon receptor 2 (AHR2), with a pIC50 of 7.319. Benz[a]anthracene can be detected in spruce needles near aluminum smelters. Exposure to Benz[a]anthracene during zebrafish embryonic stage activates the AHR-CYP1A signaling pathway and induces AHR2 expression, leading to social behavioral deficits that persist into adulthood, accompanied by impaired neuro-immune interaction, while anxiety levels remain unaffected. Benz[a]anthracene can be used in studies related to PAH environmental toxicology, developmental neurotoxicity and biodegradation .
Cat. No.: HY-160125
CAS No.: 2154373-61-0
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25,25-Difluoro-27-norcholestenoic acid is an LXRb ligand that disrupts the His435-Trp457 aromatic-aromatic interaction, destabilizing the H11-H12 region and favoring corepressor binding .
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Bathocuproine is a phenanthroline chelator that binds specifically to Cu +. Bathocuproine preferentially binds Cu + over Cu 2+ to form a chromogenic complex, which is used to detect the oxidation state of copper in biomolecules. Bathocuproine undergoes concentration-dependent self-association to form dimers, and it can engage in aromatic stacking interactions with aromatic residues of Aβ (Kd ≈ 1 mM). Bathocuproine is applicable to research related to Alzheimer's disease .
Cat. No.: HY-103084
CAS No.: 2109805-65-2
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PDE5-IN-1 is an orally active, selective PDE5 inhibitor with an IC50 of 5.6 nM. PDE5-IN-1 forms hydrogen bond interactions with the Q817 residue in the catalytic domain of PDE5, and aromatic π-π stacking interactions with the F820 residue. PDE5-IN-1 exerts anti-cardiac hypertrophy and vasodilatory effects, reduces mean pulmonary arterial pressure and right ventricular hypertrophy index. PDE5-IN-1 can be used in the research of pulmonary arterial hypertension .
Cat. No.: HY-183603
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FRC-222 is a CHD1 tandem chromodomain inhibitor with a Kd of 0.15 μM and an IC50 of 0.18 μM. FRC-222 binds to the H3K4me3 binding site of CHD1 tandem chromodomain via aromatic cage interactions and extended ligand contacts. FRC-222 can be used for the research of prostate cancer[1].
Cat. No.: HY-183602
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FRC-303 is a CHD1 inhibitor with a Kd of 0.14 μM and an IC50 of 0.18 μM. FRC-303 binds to the H3K4me3 binding site of CHD1 tandem chromodomain, forms aromatic cage interactions and extended ligand contacts, acts as a methyl-lysine mimic, and occupies natural peptide ligand-binding regions. FRC-303 can be used for the research of prostate cancer .
Cat. No.: HY-P992360
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Cat. No.: HY-L913
105 compounds
Recently, significant advancements in tyrosine-targeting electrophiles have primarily occurred in the field of protein-protein interactions (PPIs), where cysteine residues are often underrepresented and novel chemistries are needed to address these interfaces. In this context, tyrosines are frequently more accessible compared to more buried binding sites. Moreover, they are commonly found at "hot spots," which are functional epitopes of PPIs, with 12.3% of the residues consisting of tyrosines. This prevalence is likely due to the hydrophobic nature of tyrosine, its ability to participate in aromatic π-interactions, and its capacity for hydrogen bonding. Beyond PPIs, some progress has also been made in covalent tyrosine targeting in other areas where more commonly addressed side chains are lacking. Even though tyrosine has a slightly lower pKa value compared to the protonated lysine side chain (approximately 10 vs. 10.5 for the unprotected amino acid side chains), significantly less progress has been made in the development of tyrosine-targeted covalent ligands compared to lysine. This is likely due to the reduced flexibility of the tyrosine side chain and the greater steric hindrance of its hydroxy group, which makes it more challenging to adopt suitable reaction geometries.
Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 124 fragment molecules which can target tyrosine residue and can be used for fragment-based covalent drug discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
