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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
arsenicals
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "arsenicals" in MCE Product Catalog:
4
4 Cited Publications
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ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 is able to disrupt the Cdc42-ITSN interaction as well as GTP/GDP binding. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used for the studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC) .
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1 Cited Publications
Synonyms: 2,3-Dimercapto-1-propanol; Dithioglycerol
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .
Synonyms: DiMC; CHC 004; Di-O-methylcurcumin
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Androgen Receptor Reactive Oxygen Species (ROS) Apoptosis NF-κB CDK Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase PI3K Akt AMPK ERK JNK
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Dimethoxycurcumin (DiMC) is a curcuminoid compound found in Curcuma longa. Dimethoxycurcumin is also an orally active thioredoxin reductase inhibitor (IC50 = 5.4 μM) and androgen receptor antagonist. Dimethoxycurcumin inhibits thioredoxin reductase, leading to oxidized thioredoxin accumulation, ROS production, DNA damage, glutathione depletion, mitochondrial membrane potential decrease, ATP depletion, S phase arrest, and apoptosis. Dimethoxycurcumin inhibits NF-κB, NADPH oxidase subunits, ATP synthase subunits, CDK4, cyclin-D1, FASN, ACC, and the IRS2-PI3K-Akt pathway, while activating AMPK, ERK, and JNK. Dimethoxycurcumin can be used for research on cancer, arsenic-induced hepatotoxicity, and tuberculosis .
Cat. No.: HY-138502A
CAS No.: 89141-50-4
Melarsomine dihydrochloride is a trivalent arsenical compound used as an adulticide. Melarsomine dihydrochloride can be used for the reserach of canine heartworm disease and other helminth infections .
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important agent for African trypanosomiasis. Melarsoprol inhibits the growth of lymphoid leukemic cell by inducing apoptosis. Melarsoprol crosses the blood-brain barrier .
Cat. No.: HY-W741573
CAS No.: 212391-23-6
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N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols. N-Biotinyl p-aminophenyl arsenic acid decreases the Rbungarotoxin-binding sites in reduced Torpedo nicotinic receptors (IC50 is 10-300 nM), and protects the receptor from irreversible alkylation by bromoacetylcholine .
Synonyms: ZIO-101; S-Dimethylarsino-glutathione
Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects .
Cat. No.: HY-138502
CAS No.: 128470-15-5
Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections .
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Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside is a furanose derivative. Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside serves as an important intermediate for the synthesis of compounds such as arsenic-containing ribosides .
Cat. No.: HY-W017224
CAS No.: 2386-54-1
Synonyms: Sodium 1-butanesulfonate
Synonyms: 2,3-Dimercapto-1-propanol (Standard); Dithioglycerol (Standard)
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Dimercaprol (Standard) is the analytical standard of Dimercaprol. This product is intended for research and analytical applications. Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .
Cat. No.: HY-120914
CAS No.: 170950-29-5
Synonyms: GO-Y015
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Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism Drug Derivative TrxR
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TrxR1-IN-B19 (GO-Y015) is a Curcumin (HY-N0005) derivative and TrxR1 inhibitor. TrxR1-IN-B19 inhibits de novo selenoprotein synthesis, suppresses SeP and GPx expression, and impairs selenium incorporation into Sec-tRNA[Sec]. TrxR1-IN-B19 induces Nrf2 accumulation through Keap1 cysteine modification, HO-1 expression, GSH synthesis, ROS accumulation, ER stress, mitochondrial dysfunction, Apoptosis, and G2/M phase arrest. TrxR1-IN-B19 improves glucose tolerance and insulin sensitivity, lowers blood glucose, inhibits tumor growth, and reduces arsenic accumulation. TrxR1-IN-B19 can be used for research on type 2 diabetes, arsenite-induced toxicity, and gastric cancer .
Cat. No.: HY-145909
CAS No.: 2835555-10-5
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BRD4 Inhibitor-17 (Compound 5i) is a potent inhibitor of BRD4 with an IC50 of 0.33 μM. BRD4 Inhibitor-17 plays crucial role in regulating transcription of inflammatory, proliferation and cell cycle genes. BRD4 Inhibitor-17 serves as potential antidotes for arsenicals .
Cat. No.: HY-N16399
Arsthinenol (Arsthinol; Balarsen) is an orally active small organic arsenic molecule. Arsthinenol exhibits anti-amoebic activity by eliminating cysts and trophozoites of Entamoeba histolytica in feces and promoting the healing of amoebic rectal ulcers. Arsthinenol forms the hydroxypropyl-β-cyclodextrin inclusion complex STB-HPβCD, which has an IC50 of 31.6 μM against U87 MG cells and possesses anti-tumor activity. Arsthinenol can be used in the research of intestinal amoebiasis and glioblastoma .
Cat. No.: HY-100977S
CAS No.: 3006902-95-7
Synonyms: DiMC-d6; CHC 004-d6; Di-O-methylcurcumin-d6
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Isotope-Labeled Compounds Androgen Receptor Reactive Oxygen Species (ROS) Apoptosis NF-κB CDK Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase PI3K Akt AMPK ERK JNK
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Dimethoxycurcumin-d6 (DiMC-d6; CHC 004-d6; Di-O-methylcurcumin-d6) is the deuterated-labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin (DiMC) is a curcuminoid compound found in Curcuma longa. Dimethoxycurcumin is also an orally active thioredoxin reductase inhibitor (IC50 = 5.4 μM) and androgen receptor antagonist. Dimethoxycurcumin inhibits thioredoxin reductase, leading to oxidized thioredoxin accumulation, ROS production, DNA damage, glutathione depletion, mitochondrial membrane potential decrease, ATP depletion, S phase arrest, and apoptosis. Dimethoxycurcumin inhibits NF-κB, NADPH oxidase subunits, ATP synthase subunits, CDK4, cyclin-D1, FASN, ACC, and the IRS2-PI3K-Akt pathway, while activating AMPK, ERK, and JNK. Dimethoxycurcumin can be used for research on cancer, arsenic-induced hepatotoxicity, and tuberculosis .
Cat. No.: HY-177995
CAS No.: 142609-62-9
Synonyms: Monoisoamyl meso-2,3-dimercaptosuccinic acid
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MiADMSA (Monoisoamyl meso-2,3-dimercaptosuccinic acid) is an orally active thiol chelator that can effectively remove heavy metals such as arsenic and lead from the body of animals. Arsenic binds with two vicinal sulfhydryl groups available in MiADMSA leading to marked reduction in body arsenic burden and also marked reduction in various oxidative stress parameters and antioxidant enzymes like-ROS, nitrite, TBARS, GSH, SOD and catalase. MiADMSA attenuates urinary bladder carcinogenesis, protects against oxidative stress, ameliorates copper-induced histopathology, reverses neurotoxicity, and is safe in animals. MiADMSA can be used in studies of bladder cancer, arsenic, and lead-induced developmental neurotoxicity .
Cat. No.: HY-P11946
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
