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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
cTP-AlkF-2
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "cTP-AlkF-2" in MCE Product Catalog:
Cat. No.: HY-188197
Research Areas:
VtCD-cTP-ALKF-2 is a DAPK1 PROTAC degrader. VtCD-cTP-ALKF-2 can bind to dephosphorylated DAPK1, recruit VHL E3 ligase, and induce ubiquitin-proteasome-mediated degradation. VtCD-cTP-ALKF-2 can be used for research on Alzheimer's disease .
Cat. No.: HY-188196
Target:
Research Areas:
PVtCD-cTP-AlkF-2 is a ROS-responsive DAPK1 BmTAC activator with blood-brain barrier permeability. PVtCD-cTP-AlkF-2 is equipped with a VHL E3 ubiquitin ligase ligand modified with a ROS-responsive phenylboronic acid caging group, and undergoes uncaging activation only in a high-ROS microenvironment. PVtCD-cTP-AlkF-2 can selectively recognize and degrade dephosphorylated activated DAPK1. PVtCD-cTP-AlkF-2 exerts its activator function through caveolae-mediated transcytosis. PVtCD-cTP-AlkF-2 reduces APP and Tau phosphorylation, decreases Aβ oligomer deposition, and improves cognitive function in aged APP/PS1 mice. PVtCD-cTP-AlkF-2 can be used for research on Alzheimer's disease .
Cat. No.: HY-188198
Target:
Research Areas:
VHL Ligand 44 is an E3 ubiquitin ligase ligand that recruits VHL. VHL Ligand 44 can be used to synthesize PROTACs, such as PVtCD-cTP-AlkF-2 (HY-188196) .
Cat. No.: HY-P12376
CAS No.: 1432595-61-3
Target:
Research Areas:
DAPK1-binding peptide is a peptide derived from GluN2B that selectively recognizes the activated, dephosphorylated DAPK1 kinase. DAPK1-binding peptide can serve as the binder moiety of PVtCD-cTP-AlkF-2 (HY-188196) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
