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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
chain termination
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "chain termination" in MCE Product Catalog:
83
83 Cited Publications
Cat. No.: HY-K1057
Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. It can kill most gram-positive bacteria and various animal or insect cells.
Synonyms: (-)-Emtricitabine triphosphate tetrasodium salt
Research Areas:
Emtricitabine triphosphate tetrasodium salt ((-)-Emtricitabine triphosphate tetrasodium salt) is the phosphorylated active metabolite of Emtricitabine (HY-17427). Emtricitabine triphosphate inhibits HIV-1 reverse transcriptase and incorporates into the nascent viral DNA chain, causing chain termination. Emtricitabine triphosphate tetrasodium salt can serve as a biomarker for assessing adherence to antiretroviral therapy. Emtricitabine triphosphate (tetrasodium salt) can be used in research related to HIV infection .
Cat. No.: HY-131603
CAS No.: 143188-53-8
Synonyms: 3TCTP
Research Areas:
Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA .
Cat. No.: HY-17422S1
CAS No.: 1185179-33-2
Synonyms: Aciclovir-d4; Acycloguanosine-d4
Synonyms: NM283 dihydrochloride
Research Areas:
Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination .
Cat. No.: HY-108060
CAS No.: 640281-90-9
Synonyms: NM283
Research Areas:
Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination .
Cat. No.: HY-131596
CAS No.: 145819-92-7
Synonyms: (-)-Emtricitabine triphosphate
Research Areas:
Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) is the phosphorylated active metabolite of Emtricitabine (HY-17427). Emtricitabine triphosphate inhibits HIV-1 reverse transcriptase and incorporates into the nascent viral DNA chain, causing chain termination. Emtricitabine triphosphate can serve as a biomarker for assessing adherence to antiretroviral therapy. Emtricitabine triphosphate (tetrasodium salt) can be used in research related to HIV infection .
Cat. No.: HY-W1119950
CAS No.: 1644649-86-4
Research Areas:
3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is an adenine nucleotide monomer precursor used in solid-phase synthesis of oligonucleotides, particularly modified oligonucleotides, such as those with DNA chain end modifications. 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite, with trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, is a ddNTP adenosine nucleoside useful in applications such as solid-phase oligonucleotide synthesis, probe design, and chain-termination sequencing .
Cat. No.: HY-131603B
CAS No.: 2736455-56-2
Synonyms: 3TCTP TEA
Research Areas:
Lamivudine triphosphate (3TCTP) TEA is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate TEA inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate TEA is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate TEA can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA .
Cat. No.: HY-171587
CAS No.: 69383-05-7
3′-Deoxy CTP is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs .
Cat. No.: HY-W784572
CAS No.: 28120-63-0
Synonyms: 3'-O-Acetyl-2'-deoxyadenosine-5'-O-triphosphate
Target:
Research Areas:
3'-O-Acetyl-dATP is an acetylated derivative of dATP (HY-136648). It has been used as a DNA synthesis chain termination reagent in Sanger sequencing.
Cat. No.: HY-171587A
3′-Deoxy CTP trisodium is the sodium salt form of 3′-Deoxy CTP (HY-171587). 3′-Deoxy CTP trisodium is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP trisodium can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP trisodium can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs .
Cat. No.: HY-172002
CAS No.: 98923-57-0
Synonyms: 3'-O-Methyl GTP sodium
Target:
Research Areas:
3'-O-Methylguanosine-5'-O-triphosphate (3'-O-Methyl GTP) sodium is a methylated derivative of Guanosine 5'-triphosphate (HY-W010737). 3'-O-Methylguanosine-5'-O-triphosphate has been used as a chain termination reagent in the preparation of early RNA polymerase II elongation intermediates.
Cat. No.: HY-W784572A
Synonyms: 3'-O-Acetyl-2'-deoxyadenosine-5'-O-triphosphate sodium
Target:
Research Areas:
3'-O-Acetyl-2'-deoxyadenosine-5'-O-triphosphate (sodium) (3'-O-Acetyl-dATP (sodium)) is an acetylated derivative of the purine nucleotide 2'-deoxyadenosine-5'-triphosphate (HY-136648). 3'-O-Acetyl-2'-deoxyadenosine-5'-O-triphosphate (sodium) can been used as a DNA synthesis chain termination reagent in Sanger sequencing.
Cat. No.: HY-108060AR
CAS No.: 640725-71-9
Synonyms: NM283 dihydrochloride (Standard)
Research Areas:
Valopicitabine dihydrochloride (Standard) is the analytical standard of Valopicitabine (dihydrochloride) (HY-108060A). This product is intended for research and analytical applications. Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination .
Cat. No.: HY-12983B
CAS No.: 1445383-14-1
Target:
Research Areas:
ALS-8112-TP is the 5'-triphosphate metabolite of ALS-8112 (HY-12983). ALS-8112-TP is a potent, selective and competitive respiratory syncytial virus (RSV) RNA polymerase inhibitor, with selectivity against polymerases from host or viruses unrelated to RSV such as hepatitis C virus (HCV). ALS-8112-TP can be efficiently recognized by the recombinant RSV polymerase complex, causing chain termination of RNA synthesis. ALS-8112-TP can be used for RSV-infection research .
Cat. No.: HY-185150
CAS No.: 114088-58-3
Synonyms: 9-(2-Phosphonylmethoxy)ethylguanine
Target:
Research Areas:
PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma [1][2].
Cat. No.: HY-P703566
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ETF1; Eukaryotic Peptide chain Release Factor Subunit 1; Prev. ERF1; Polypeptide chain Release Factor 1; Prev. SUP45L1; Protein Cl1; Prev. ERF; Eukaryotic Release Factor 1; TB3-1; D5S1995; RF1; Eukaryotic Translation termination Factor 1; Sup45 (Yeast Omn
Species:
Human
Source:
E. coli
Cat. No.: HY-P702942
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ETF1; Eukaryotic Peptide chain Release Factor Subunit 1; Prev. ERF1; Polypeptide chain Release Factor 1; Prev. SUP45L1; Protein Cl1; Prev. ERF; Eukaryotic Release Factor 1; TB3-1; D5S1995; RF1; Eukaryotic Translation termination Factor 1; Sup45 (Yeast Omn
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
