202

202 Publications Verification

Target:

MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

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23

Itacitinib

23 Cited Publications

Cat. No.: HY-16997

CAS No.: 1334298-90-6

Synonyms: INCB039110

Target:

JAK STAT

Research Areas:

Inflammation/Immunology Cancer

Itacitinib (INCB039110) is an orally active selective inhibitor of JAK1 with an IC₅₀ value of 2 nM for human JAK1. Itacitinib inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .

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23

Itacitinib adipate

23 Cited Publications

Cat. No.: HY-16997A

CAS No.: 1334302-63-4

Synonyms: INCB039110 adipate

Target:

JAK STAT

Research Areas:

Inflammation/Immunology Cancer

Itacitinib adipate (INCB039110 adipate) is an orally active JAK1-selective inhibitor. Itacitinib adipate inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib adipate reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib adipate improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib adipate can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .

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7

Brinzolamide

7 Cited Publications

Cat. No.: HY-B0588

CAS No.: 138890-62-7

Synonyms: AL-4862

Target:

Carbonic Anhydrase

Research Areas:

Cardiovascular Disease Others Neurological Disease

Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

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6

Choline chloride

6 Cited Publications

Cat. No.: HY-B1337

CAS No.: 67-48-1

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Histamine Receptor

Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline theophyllinate

6 Cited Publications

Cat. No.: HY-B1718

CAS No.: 4499-40-5

Synonyms: Oxtriphylline

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Histamine Receptor

Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline (bitartrate)

6 Cited Publications

Cat. No.: HY-101036

CAS No.: 87-67-2

Purity: ≥98.0%

Category:

Animals Ketones, Aldehydes, Acids

Target:

Histamine Receptor

Choline bitartrate (Oxtriphylline) is an orally active methylxanthine-derived choline salt of theophylline. Choline bitartrate exhibits weak antihistaminic and anticholinergic activities and can enhance the effects of histamine and acetylcholine. Choline bitartrate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates central nervous system motor activity, and induces transient hypotension following a pressor phase. Choline bitartrate modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline bitartrate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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5

Ibutamoren

5 Cited Publications

Cat. No.: HY-10199A

CAS No.: 159634-47-6

Purity: 98.52%

Synonyms: MK-677 free base; MK-0677 free base

Target:

GHSR Insulin Receptor

Research Areas:

Neurological Disease Metabolic Disease

Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis .

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4

Netupitant

4 Cited Publications

Cat. No.: HY-16346

CAS No.: 290297-26-6

Synonyms: CID 6451149

Target:

Neurokinin Receptor

Netupitant (CID 6451149) is a blood-brain barrier penetrable, orally active NK1 receptor inhibitor with a K_i of 0.95 nM (CHO cells) against the human receptor. Netupitant antagonizes the effects induced by Substance P, inhibits the maximal response of Substance P with a long-lasting action, and suppresses NK1 agonist-induced behaviors in mice and gerbils. Netupitant reduces the frequency of bladder contractions, prolongs contraction intervals, decreases basal pressure at high doses, and acts on the afferent branch of the micturition reflex. Netupitant can be used in research related to overactive bladder, chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, anxiety disorders, and depression .

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3

Vernakalant Hydrochloride

3 Cited Publications

Cat. No.: HY-14183

CAS No.: 748810-28-8

Purity: 99.33%

Synonyms: RSD1235 hydrochloride

Target:

Potassium Channel

Research Areas:

Cardiovascular Disease

Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na ⁺ and atria-preferred K ⁺ channel blocker. IC₅₀ for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channel ^wt, Kv1.5 channel ^I508F, Kv1.5 channel ^T479A, respectively.

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3

Choline-d9 chloride

3 Cited Publications

Cat. No.: HY-B1337S1

CAS No.: 61037-86-3

Target:

Isotope-Labeled Compounds Histamine Receptor

Choline-d₉ chloride is the d₉-labeled Choline chloride (HY-B1337). Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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2

Propafenone hydrochloride

2 Cited Publications

Cat. No.: HY-B0432A

CAS No.: 34183-22-7

Synonyms: SA-79 hydrochloride

Target:

Sodium Channel

Research Areas:

Cardiovascular Disease

Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

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2

Tulobuterol

2 Cited Publications

Cat. No.: HY-B1810

CAS No.: 41570-61-0

Synonyms: C-78 free base

Target:

Adrenergic Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Tulobuterol (C-78 free base) is a long-acting β₂-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .

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2

Eleclazine hydrochloride

2 Cited Publications

Cat. No.: HY-16738A

CAS No.: 1448754-43-5

Synonyms: GS 6615 hydrochloride

Target:

Sodium Channel Potassium Channel

Research Areas:

Cardiovascular Disease

Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias .

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2

Tulobuterol hydrochloride

2 Cited Publications

Cat. No.: HY-W011733

CAS No.: 56776-01-3

Synonyms: C-78

Target:

Adrenergic Receptor Influenza Virus Antibiotic

Research Areas:

Infection Inflammation/Immunology Endocrinology

Tulobuterol hydrochloride (C-78) is a long-acting β₂-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength . Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation .

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2

Eleclazine

2 Cited Publications

Cat. No.: HY-16738

CAS No.: 1443211-72-0

Synonyms: GS-6615

Target:

Sodium Channel Potassium Channel

Research Areas:

Cardiovascular Disease

Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias .

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2

CNTF Protein, Human

2 Cited Publications

Cat. No.: HY-P7146

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CNTF; HCNTF; ciliary Neurotrophic Factor; ciliary Neuronotrophic Factor

Species:

Human

Source:

E. coli

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2

CNTF Protein, Human (HEK293)

2 Cited Publications

Cat. No.: HY-P7145

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CNTF; HCNTF; ciliary Neurotrophic Factor; ciliary Neuronotrophic Factor

Species:

Human

Source:

HEK293

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2

Choline Chloride-13C3

2 Cited Publications

Cat. No.: HY-B1337S4

Target:

Isotope-Labeled Compounds Histamine Receptor

Choline Chloride- ¹³C₃ is the ¹³C-labeled Choline chloride (HY-B1337). Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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