470 Results for "

diterpenoid

" in MedChemExpress (MCE) Product Catalog:
Products (470)

470 Results for "diterpenoid" in MCE Product Catalog:

78
Triptolide
Triptolide
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78 Publications Verification
Cat. No.: HY-32735
CAS No.: 38748-32-2
Synonyms: PG490
Category:  

Anti-aging Celastraceae Extract Plants Tripterygium wilfordii Hook. f. Biological Pesticide Research Agricultural Research Terpenoids Diterpenoids Disease Research Fields Cancer

Target:  

Environmental Pollutants NF-κB Apoptosis

Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .
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28
Oridonin
Oridonin
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28 Cited Publications
Cat. No.: HY-N0004
CAS No.: 28957-04-2
Synonyms: NSC-250682; Isodonol
Category:  

Infection Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Labiatae Extract Butea monosperma Kuntze

Target:  

Akt Bacterial Ligands for E3 Ligase

Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
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8
Ryanodine
Ryanodine
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8 Cited Publications
Cat. No.: HY-103306
CAS No.: 15662-33-6
Purity:  99.35%
Category:  

Neurological Disease Terpenoids Ryania speciosa Diterpenoids Plants Other Families Extract Disease Research Fields Biological Pesticide Research Agricultural Research

Target:  

Environmental Pollutants Calcium Channel

Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.
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3
Phytol
Phytol
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3 Cited Publications
Cat. No.: HY-N3075
CAS No.: 150-86-7
Synonyms: (E)​-​Phytol
Category:  

Infection Microorganisms Ginkgoaceae Extract Terpenoids Ginkgo biloba L. Diterpenoids Plants Disease Research Fields Food Research

Target:  

Parasite Bacterial Keap1-Nrf2

Phytol ((E)-Phytol) is an orally active diterpenoid alcohol that can be extracted from chlorophyll. Phytol has antioxidant, anti-inflammatory, anti-schistosomiasis and antibacterial activities .
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3
Eriocalyxin B
Eriocalyxin B
0 Images
3 Cited Publications
Cat. No.: HY-N2303
CAS No.: 84745-95-9
Category:  

Natural Products Senna sophera (L.) Roxb. Plants Disease Research Fields Inflammation/Immunology Labiatae Extract

Target:  

Apoptosis NF-κB Autophagy Reactive Oxygen Species (ROS) CDK PPAR FABP Akt mTOR

Eriocalyxin B is a diterpenoid compound that can be isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B exhibits multiple activities, such as anti-cancer, anti-inflammatory, and inhibition of adipogenesis. Eriocalyxin B is capable of inducing apoptosis and autophagy in tumor cells. Eriocalyxin B can be used in the research of cancers, autoimmune diseases, and other conditions .
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2
Cafestol
Cafestol
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2 Cited Publications
Cat. No.: HY-N6257
CAS No.: 469-83-0
Category:  

Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Cancer Rubiaceae Extract

Target:  

ERK PGE synthase COX NF-κB Apoptosis Autophagy AP-1 FAK

Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer .
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2
Carboxyatractyloside tripotassium
Carboxyatractyloside tripotassium
0 Images
2 Cited Publications
Cat. No.: HY-N1502
CAS No.: 77228-71-8
Synonyms: Gummiferin tripotassium
Category:  

Terpenoids Diterpenoids Plants Other Families Extract Disease Research Fields Cancer

Target:  

Mitochondrial Metabolism Reactive Oxygen Species (ROS) Calcium Channel

Carboxyatractyloside tripotassium is a diterpenoid. Carboxyatractyloside tripotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside tripotassium is an ADP/ATP carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside tripotassium promotes ROS production, induces Ca 2+ release, and leads to mitochondrial dysfunction. Carboxyatractyloside tripotassium induces lethargy, weakness, and epileptic seizures in rats .
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2
Carboxyatractyloside dipotassium
Carboxyatractyloside dipotassium
0 Images
2 Cited Publications
Cat. No.: HY-N2522
CAS No.: 33286-30-5
Synonyms: Gummiferin dipotassium
Category:  

Terpenoids Other Diseases Diterpenoids Plants Other Families Extract Disease Research Fields

Target:  

Mitochondrial Metabolism Calcium Channel Reactive Oxygen Species (ROS)

Carboxyatractyloside dipotassium is a diterpenoid. Carboxyatractyloside dipotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside dipotassium is an ADP/ATP carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside dipotassium promotes ROS production, induces Ca 2+ release, and leads to mitochondrial dysfunction. Carboxyatractyloside dipotassium induces lethargy, weakness, and epileptic seizures in rats .
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1
Euphorbia factor L7a
Euphorbia factor L7a
0 Images
1 Cited Publications
Cat. No.: HY-N8121
CAS No.: 93550-94-8
Category:  

Terpenoids Other Diseases Euphorbia lathylris Linnaeus Diterpenoids Plants Disease Research Fields Euphorbiaceae Extract

Target:  

Others

Euphorbia factor L7a, a diterpenoid compound, can be isolated from the seeds of Euphorbia lathyris .
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1
5,15-Diacetyl-3-benzoyllathyrol
5,15-Diacetyl-3-benzoyllathyrol
0 Images
1 Cited Publications
Cat. No.: HY-N0562
CAS No.: 218916-52-0
Synonyms: Euphorbia factor L3
Category:  

Terpenoids Leptochloa chinensis (Linn.) Nees Diterpenoids Plants Gramineae Extract Disease Research Fields Cancer

Target:  

Others

5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.
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1
Salviolone
Salviolone
0 Images
1 Cited Publications
Cat. No.: HY-122506
CAS No.: 119400-86-1
Purity:  99.61%
Category:  

Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Labiatae Extract

Target:  

STAT

Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells .
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1
Glaucocalyxin B
Glaucocalyxin B
0 Images
1 Cited Publications
Cat. No.: HY-N2113
CAS No.: 80508-81-2
Category:  

Terpenoids Sesquiterpenes Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer Labiatae Extract

Target:  

Autophagy

Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h.
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1
Hardwickiic acid
Hardwickiic acid
0 Images
1 Cited Publications
Cat. No.: HY-N3990
CAS No.: 1782-65-6
Synonyms: (-)-Hardwickiic acid; (-)-Hardwikiic acid
Category:  

Pueraria tuberosa (Roxb. ex Willd.) DC. Neurological Disease Plants Other Families Extract Infection Croton tiglium Linn. Terpenoids Diterpenoids Compositae Extract Disease Research Fields Euphorbiaceae Extract

Target:  

Sodium Channel Parasite

Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases .
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1
Euphorbia Factor L2
Euphorbia Factor L2
0 Images
1 Cited Publications
Cat. No.: HY-N5001
CAS No.: 218916-51-9
Category:  

Terpenoids Leptochloa chinensis (Linn.) Nees Diterpenoids Plants Gramineae Extract Disease Research Fields Cancer

Target:  

Apoptosis

Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway .
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1
Columbin
Columbin
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1 Cited Publications
Cat. No.: HY-N0389
CAS No.: 546-97-4
Category:  

Terpenoids Diterpenoids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

COX Parasite

Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .
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1
Erinacine P
Erinacine P
0 Images
1 Cited Publications
Cat. No.: HY-N11019
CAS No.: 291532-17-7
Category:  

Hericium erinaceus (Bull.) Pers. Human Gut Microbiota Metabolites Microorganisms Terpenoids Diterpenoids Endogenous metabolite

Target:  

Bacterial

Erinacine P is a cyathane-type diterpenoid antibacterial agent. Erinacine P is isolated from the biosynthesis of mycelia and submerged cultures of Hericium erinaceum. Erinacine P serves as a precursor for the production of important active components such as Erinacine C, A and B. Erinacine P exhibits significant antibacterial activity against Aliivibrio fischeri .
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Kamebakaurin
Kamebakaurin
0 Images
1 Cited Publications
Cat. No.: HY-N6046
CAS No.: 73981-34-7
Category:  

Hymenaea verrucosa Gaertn. Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Cancer Labiatae Extract

Target:  

NF-κB Apoptosis Caspase HIF/HIF Prolyl-Hydroxylase

Kamebakaurin is an orally active diterpenoid compound that can be isolated from Isodon excia (Maxin.). Kamebakaurin can inhibit NF-κB activation by directly targeting the DNA-binding activity of p50. Kamebakaurin can induce apoptosis and cell cycle arrest in tumor cells. Kamebakaurin has anti-inflammatory and anti-tumor activities .
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Rebaudioside M
Rebaudioside M
0 Images
1 Cited Publications
Cat. No.: HY-N6833
CAS No.: 1220616-44-3
Category:  

Plants Other Families Extract Sweeteners Food Research Trifolium hybridum L. Terpenoids Other Diseases Diterpenoids Compositae Extract Disease Research Fields

Target:  

Others

Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .
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Neoandrographolide
Neoandrographolide
0 Images
1 Cited Publications
Cat. No.: HY-N0721
CAS No.: 27215-14-1
Synonyms: Neoandrographiside
Category:  

Acanthaceae Extract Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

ERK p38 MAPK JNK NF-κB PI3K PPAR GSK-3 CaMK NO Synthase Reactive Oxygen Species (ROS) Apoptosis

Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates eNOS, exhibiting anti-inflammatory and hypolipidemic activity .
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Kirenol
Kirenol
0 Images
1 Cited Publications
Cat. No.: HY-N0559
CAS No.: 52659-56-0
Category:  

Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Extract

Target:  

Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad

Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .
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