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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
helical structure
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "helical structure" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N6708
CAS No.: 27061-78-5
Category:
Infection Antibiotics Mammalian Cell Culture Microorganism Disease Research Antibacterial Disease Research Fields Other Antibiotics
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1 Cited Publications
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Semustine is an orally active, blood-brain barrier permeable antitumor alkylating agent with a binding affinity of 1.53 × 10 3 M -1 for guanine and thymine residues in bovine DNA. Semustine undergoes major groove-directed alkylation at guanine residues to form O6-chloroethylguanine and N1-O6-ethanoguanine adducts, and generates dG-dC interstrand crosslinks. Semustine induces partial B- to C-type transition of DNA, base stacking and helical structure distortion, mild dehydration, as well as partial DNA double-strand unwinding. Semustine can be used in research related to Lewis lung cancer, leukemia, Hodgkin's lymphoma, malignant melanoma, glioma, and diffuse large B-cell lymphoma .
Synonyms: A22 hydrochloride
MreB Perturbing Compound A22 hydrochloride (A22 hydrochloride) is a reversible MreB inhibitor and antimicrobial agent that exhibits bacteriostatic activity against Escherichia coli, with low activity against Gram-positive bacteria. MreB Perturbing Compound A22 hydrochloride rapidly and reversally delocalizes MreB from the helical/circular structures in cells, impairs MreB function, and reduces the binding of MreB to the chromosomal region proximal to the replication origin. MreB Perturbing Compound A22 hydrochloride alters the cell morphology of caulobacters to round/lemon-shaped, slows caulobacter growth, blocks their cell division, and induces the formation of spherical morphology, asymmetric division, and anucleate cells in Escherichia coli. MreB Perturbing Compound A22 hydrochloride is used for studies related to bacterial rod-shaped morphology determination, chromosome segregation, and cell division mechanisms .
Cat. No.: HY-P5557
CAS No.: 1429184-62-2
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Cat. No.: HY-P2530
CAS No.: 187987-64-0
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Cat. No.: HY-W006886
CAS No.: 945212-26-0
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Cat. No.: HY-150536
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EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity .
Cat. No.: HY-118773R
CAS No.: 22816-60-0
Synonyms: A22 hydrochloride (Standard)
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MreB Perturbing Compound A22 hydrochloride (Standard) is the analytical standard for MreB Perturbing Compound A22 hydrochloride (HY-118773). This product is intended for research and analytical applications. MreB Perturbing Compound A22 hydrochloride (A22 hydrochloride) is a reversible MreB inhibitor and antimicrobial agent that exhibits bacteriostatic activity against Escherichia coli, with low activity against Gram-positive bacteria. MreB Perturbing Compound A22 hydrochloride rapidly and reversally delocalizes MreB from the helical/circular structures in cells, impairs MreB function, and reduces the binding of MreB to the chromosomal region proximal to the replication origin. MreB Perturbing Compound A22 hydrochloride alters the cell morphology of caulobacters to round/lemon-shaped, slows caulobacter growth, blocks their cell division, and induces the formation of spherical morphology, asymmetric division, and anucleate cells in Escherichia coli. MreB Perturbing Compound A22 hydrochloride is used for studies related to bacterial rod-shaped morphology determination, chromosome segregation, and cell division mechanisms .
Cat. No.: HY-P11353
CAS No.: 117138-19-9
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Cat. No.: HY-180334
CAS No.: 120004-07-1
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S-312 is a calcium antagonist with a bicyclic dihydrothienopyridine structure. S-312 can relax the helical strips of various isolated rabbit arteries procontracted with high potassium depolarizaiton. S-312 competitively imhibits calcium-induced contractions in depolarized basilar and femoral arteries. S-312 increases AV nodal conduction time in Langenedorff-perfused isolated rabbit hearts. S-312 exhibits vasculoselectivity, particularly for cerebral vessel .
Cat. No.: HY-P12210
CAS No.: 1001644-68-3
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Antimicrobial peptide BP100 is a linear undecapeptide with an amphipathic α-helical structure that exhibits antibacterial activity. Antimicrobial peptide BP100 shows in vitro antibacterial activity against a variety of plant and human pathogens. Antimicrobial peptide BP100 binds to and inserts into bacterial cell membranes through electrostatic attraction, triggering membrane permeabilization and ultimately leading to membrane disruption. Antimicrobial peptide BP100 can be used for research on bacterial infections .
Cat. No.: HY-P12259
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4F-P-4F peptide is an apoA-I mimetic peptide with a class A amphipathic α-helical structure that acts on ABCA1 and SR-B. 4F-P-4F peptide induces cholesterol efflux from cholesterol-loaded mouse macrophages and promotes HDL remodeling in plasma. 4F-P-4F peptide can be used in research on asthma and atherosclerosis .
Cat. No.: HY-P12210A
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Antimicrobial peptide BP100 TFA is a linear undecapeptide with an amphipathic α-helical structure that exhibits antibacterial activity. Antimicrobial peptide BP100 TFA shows in vitro antibacterial activity against a variety of plant and human pathogens. Antimicrobial peptide BP100 TFA binds to and inserts into bacterial cell membranes through electrostatic attraction, triggering membrane permeabilization and ultimately leading to membrane disruption. Antimicrobial peptide BP100 TFA can be used for research on bacterial infections .
Cat. No.: HY-167189
CAS No.: 682763-67-3
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BF-158 is a quinoline-based Tau Protein fluorescent imaging probe that produces specific staining by recognizing the β-sheet structure of paired helical filaments (PHF)/neurofibrillary tangles (NFT) in tau aggregates, with EC50 values of 399 nM and 659 nM for tau fibrils and Aβ1-42 fibrils, respectively. BF-158 preferentially labels NFTs, neuropil threads, and PHF-type neurites. BF-158 is useful for the study and imaging of tau pathology in Alzheimer's disease .
Cat. No.: HY-DY2032
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Methyl Green Staining Solution (Chloroform-Extracted, 1%) is a basic dye stock solution with differential nucleic acid binding activity that distinguishes double-stranded DNA from RNA, and it can be used for assays related to nucleic acid distribution and DNA localization. Methyl Green Staining Solution (Chloroform-Extracted, 1%) functions by competitively binding to the phosphate groups of nucleic acids and stably binds to intact double-stranded DNA; RNA within the oocyte-specific ribonucleoprotein complex specifically binds to this dye, and RNase completely blocks this binding reaction. The nucleic acid recognition of Methyl Green Staining Solution (Chloroform-Extracted, 1%) depends on the size of the dye cation and the intact double-helical structure of DNA .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
