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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
human CDK4
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "human CDK4" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N6845
CAS No.: 19275-46-8
1
1 Cited Publications
Cat. No.: HY-P72785
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4); Prev. CDKN2; Multiple Tumor Suppressor 1; Prev. MLM; CDKN2A/ARF Intron 2 LncRNA; P14ARF; Alternative Reading Frame; CDK4I; Inhibitor Of CDK4 A; MTS1; MTS-1; P16; Truncated Tumor
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P702682
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK4; Cyclin-Dependent Kinase 4; Cyclin Dependent Kinase 4; Cyclin-Dependent Kinase; PSK-J3; MCPH31; Cell Division Protein Kinase 4; CMM3; CCND1; B-Cell CLL/Lymphoma 1; Prev. PRAD1; PRAD1 Oncogene; Prev. BCL1; Parathyroid Adenomatosis 1; Prev. D11S287E; C
Species:
Human
Source:
Sf9 insect cells
Synonyms: Hetrombopag (tautomerism); SHR-8735 (tautomerism)
Research Areas:
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Cat. No.: HY-145589
CAS No.: 2600513-51-5
Synonyms: Hetrombopag; SHR-8735
Research Areas:
Rafutrombopag (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Cat. No.: HY-119715
CAS No.: 486414-35-1
Research Areas:
AG-012986 is a pan-CDK inhibitor with Ki values of 44 nM (CDK1), 9.2 nM (CDK4), 94 nM (CDK2), and IC50 values of 22 nM (CDK5), 4 nM (CDK9). AG-012986 causes apoptosis of T-cells by targeting upstream kinases in the p38 Mitogen-activated protein kinase (MAPK) pathway and impairing cellular survival. AG-012986 induces cell cycle arrest, retinoblastoma protein hypophosphorylation, and reduces Ki-67 expression. AG-012986 exerts antiproliferative activity in tumor cells, demonstrates antitumor efficacy in human xenograft models, and causes retinal and peripheral neurotoxicity, plus immune cell toxicity. AG-012986 can be used for the research of colon carcinoma, non-small cell lung carcinoma, lung carcinoma, breast carcinoma, ovarian tumor, pancreatic carcinoma, osteosarcoma, lymphoma, leukemia, retinotoxicity .
Cat. No.: HY-RS02381
Target:
Research Areas:
CDK4 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-124398
CAS No.: 591242-70-5
GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research .
Cat. No.: HY-116204
CAS No.: 1257317-77-3
SKLB70326 is a small molecule inhibitor of cell cycle progression that induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. SKLB70326 is involved in downregulating cyclin-dependent kinase (CDK) 2, CDK4, and CDK6, while also activating PARP, caspase-3, caspase-9, and Bax, and downregulating Bcl-2.
Cat. No.: HY-P85531
Synonyms: CDK 4; CDK4; CDK4 protein; CDK4_human; Cell division kinase 4; Cell division protein kinase 4; CMM 3; CMM3; Crk3; Cyclin dependent kinase 4; Cyclin-dependent kinase 4; Melanoma cutaneous malignant 3; MGC14458; p34 CDK4; PSK J3; PSK-J3.
Cat. No.: HY-125101A
CAS No.: 1257792-42-9
Rafutrombopag (Hetrombopag) diolamine is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag diolamine can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag diolamine specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag diolamine effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag diolamine protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag diolamine can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Cat. No.: HY-P704003
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK4; Cyclin-Dependent Kinase 4; Cyclin Dependent Kinase 4; Cyclin-Dependent Kinase; PSK-J3; MCPH31; Cell Division Protein Kinase 4; CMM3
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-128491
CAS No.: 748142-06-5
Target:
Research Areas:
UNC10112785 is a serine/threonine kinase inhibitor with a human GSK-3β IC50 of 0.031 μM, human CDK-2 IC50 of 0.016 μM, and human CDK-4 IC50 of 1.99 μM. UNC10112785 can be used for the research of type 2 diabetes .
Cat. No.: HY-183529
CAS No.: 551919-54-1
Antitrypanosomal agent 31 is an antitrypanosoma agent with a pEC50 of 6.4. Antitrypanosomal agent 31 inhibits GSK-3β, CDK-2, and CDK-4 with pIC50s of 5.8, 6.9, and 7.1, respectively. Antitrypanosomal agent 31 can be used for the research of human african trypanosomiasis .
Cat. No.: HY-182734
CAS No.: 350509-99-8
BMS-357075 is a pan-CDK inhibitor with CDK1 IC50 18 nM, CDK2 IC50 3 nM, CDK4 IC50 26 nM. BMS-357075 induces cytotoxicity in human ovarian cancer A2780 cells. BMS-357075 exhibits anticancer activity in mice against P388 murine leukemia. BMS-357075 can be used for the research of leukemia .
Cat. No.: HY-P702684
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK4; Cyclin-Dependent Kinase 4; Cyclin Dependent Kinase 4; Cyclin-Dependent Kinase; PSK-J3; MCPH31; Cell Division Protein Kinase 4; CMM3; CCND3; G1/S-Specific Cyclin-D3; Cyclin D3; D3-Type Cyclin
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
