Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
hydrogen-bonding interactions
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "hydrogen-bonding interactions" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: Kaempferol 3-O-neohesperidoside
Category:
Flavonols Plant Flavonoids Typhaceae Extract Metabolic Disease Typha orientalis Presl Extract Phenols Polyphenols Disease Research Fields
Target:
1
1 Cited Publications
Research Areas:
IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π−π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders .
1
1 Cited Publications
Cat. No.: HY-N6845
CAS No.: 19275-46-8
Cat. No.: HY-177063
CAS No.: 296790-70-0
Target:
Research Areas:
IL-6-IN-2 is an interleukin-6 (IL-6) inhibitor. IL-6-IN-2 binds to IL-6 at Lys66, Phe74, Gln175, Ser176, and Arg179 via π-π, π-alkyl, hydrogen bond, and hydrophobic interactions to block IL-6/IL-6R heterocomplex formation. IL-6-IN-2 exhibits low gastrointestinal absorption rate. IL-6-IN-2 can be used for the research of cytokine release syndrome, covid-19 .
Cat. No.: HY-172997
CAS No.: 1147526-22-4
Target:
Research Areas:
GluN1/3A-IN-1 (Compound GM-10) is a GluN1/GluN3A NMDA receptor inhibitor. GluN1/3A-IN-1 exhibits potent inhibitory activity against GluN1/GluN3A (IC50: 0.98 µM). GluN1/3A-IN-1 exerts its inhibitory effect by targeting the pre-M1 region and forming hydrogen bond interactions with key residues. GluN1/3A-IN-1 can be used to study GluN1/GluN3A-related neurological diseases .
Category:
Polysaccharides Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides
Target:
Cat. No.: HY-N4031
CAS No.: 82375-29-9
Cat. No.: HY-W013396
CAS No.: 619-58-9
Target:
Research Areas:
4-Iodobenzoic acid is a 4-iodobenzoic acid that crystallizes as a dimer in the monoclinic space group P21/n, with a phase transition center temperature of 230.77 K, and exhibits intermolecular iodine-iodine van der Waals interactions. 4-Iodobenzoic acid can be used in studies of hydrogen bonding, crystal packing and solid-state phase transitions .
Cat. No.: HY-N3057
CAS No.: 18956-15-5
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Chalcones Cajanus cajan (L.) Millsp. Extract Phenols Polyphenols Disease Research Fields Cancer
Target:
Cat. No.: HY-175453
CAS No.: 3050683-03-6
Target:
Research Areas:
MRT-23227 is a CRBN-recruiting molecular glue degrader targeting VAV1. MRT-23227 binds to the tryptophan triad pocket of CRBN, forms a ternary complex with the SH3c domain of VAV1, and induces proteasomal degradation of VAV1 through hydrogen-bond interactions between CRBN residues and the RT loop and side chains of VAV1. MRT-23227 can be used in the research of T-cell leukemia and lymphoma .
Cat. No.: HY-149826
Research Areas:
MTHFD2-IN-2 is a selective MTHFD2 inhibitor with poor binding to MTHFD1. MTHFD2-IN-2 binds to the MTHFD2 substrate binding site, forming π-π stacking with Tyr84, hydrogen bond/salt-bridge contacts with Arg43 and Asn87, and lipophilic interactions with Ile276. MTHFD2-IN-2 exhibits predicted anticancer activity. MTHFD2-IN-2 can be used for the research of cancer .
Target:
Research Areas:
1,5-Naphthalenedisulfonic acid (Armstrong's acid) is an aromatic disulfonic acid compound commonly used as an intermediate in the dye industry and organic synthesis. 1,5-Naphthalenedisulfonic acid is a pharmaceutical co-former that significantly improves the solubility and thermodynamic stability of poorly soluble drugs. 1,5-Naphthalenedisulfonic acid constructs a stable supramolecular network through coordination, hydrogen bonding, and electrostatic interactions, thereby effectively preventing drug crystallization. 1,5-Naphthalenedisulfonic acid exhibits certain cytotoxicity and antitumor activity in some human hepatoma cells. 1,5-Naphthalenedisulfonic acid can be used for research on human hepatoma .
Cat. No.: HY-W009708
CAS No.: 28588-75-2
Target:
Cat. No.: HY-N10219
CAS No.: 887751-89-5
Target:
Cat. No.: HY-121125
CAS No.: 64274-28-8
Category:
Plant Iridoids Terpenoids Plantaginaceae Extract Pseudolysimachion linariifolium subsp. dilatatum (Nakai & Kitag.) D. Y. Hong Extract
Target:
Target:
Research Areas:
Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers .
Cat. No.: HY-W009071
CAS No.: 211366-30-2
Target:
Research Areas:
1,5-Naphthalenedisulfonic acid tetrahydrate is an aromatic disulfonic acid compound commonly used as an intermediate in the dye industry and organic synthesis. 1,5-Naphthalenedisulfonic acid tetrahydrate is a pharmaceutical co-former that significantly improves the solubility and thermodynamic stability of poorly soluble drugs. 1,5-Naphthalenedisulfonic acid tetrahydrate constructs a stable supramolecular network through coordination, hydrogen bonding, and electrostatic interactions, thereby effectively preventing drug crystallization. 1,5-Naphthalenedisulfonic acid tetrahydrate exhibits certain cytotoxicity and antitumor activity in some human hepatoma cells. 1,5-Naphthalenedisulfonic acid tetrahydrate can be used for research on human hepatoma .
Cat. No.: HY-156405
Research Areas:
FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC50 of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells .
Cat. No.: HY-150772
CAS No.: 2413587-26-3
Research Areas:
Tubulin/HDAC-IN-1 is a dual tubulin and HDAC-IN-1 inhibitor through CH/π interaction with tubulin and hydrogen bond interaction with HDAC8. Tubulin/HDAC-IN-1 inhibits tubulin polymerization and selectively inhibits HDAC8 (IC50: 150 nM). Tubulin/HDAC-IN-1 has cytotoxicity against various human cancer cells, also arrests cell cycle in the G2/M phase and induces cell apoptosis. Tubulin/HDAC-IN-1 can be used in the research of hematologic and solid tumors such as neuroblastoma, leukemia .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
