Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
hypersensitivity reactions
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "hypersensitivity reactions" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: NF 113; SAP 113; Methylmercadone
Research Areas:
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .
2
Target:
Research Areas:
Ampiroxicam is an orally active prodrug of non-steroidal anti-inflammatory drug (NSAID). Ampiroxicam inhibits paw swelling in adjuvant-induced arthritis and acute inflammation models, and suppresses phenylbenzoquinone-induced stretching responses in mice. Ampiroxicam is rapidly and completely converted to Piroxicam (HY-B0253) via non-specific esterases and first-pass metabolism. Ampiroxicam induces contact hypersensitivity and photosensitivity reactions through photoproducts generated by UVA. Ampiroxicam can be used in research related to photosensitivity, adjuvant-induced arthritis, rheumatism, osteoarthritis and other inflammatory diseases .
Target:
Research Areas:
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .
Research Areas:
Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions .
Cat. No.: HY-B0538A
CAS No.: 100299-08-9
Synonyms: TWT-8152; BMY 26517
Target:
Research Areas:
Pemirolast potassium is an orally active antiallergic agent. Pemirolast potassium attenuates Paclitaxel (HY-B0015) hypersensitivity reactions. Pemirolast potassium can be used for bronchial asthma and conjunctivitis research - .
Cat. No.: HY-107928A
CAS No.: 9004-66-4
Target:
Research Areas:
Iron-Dextran is an injectable complex of iron and dextran, a complex carbohydrate. It is often used to improve iron deficiency anemia, a condition characterized by low levels of iron in the blood due to insufficient dietary intake or malabsorption. Iron-glucan works by providing a source of supplemental iron that the body can use to produce hemoglobin, the protein responsible for carrying oxygen in the blood. However, caution should be exercised when taking iron dextran because it may cause hypersensitivity reactions, including anaphylaxis, and may also increase the risk of infection or other adverse reactions. Therefore, it should only be administered under the supervision of a qualified healthcare provider in a clinical setting.
Cat. No.: HY-W587780
CAS No.: 29699-89-6
Synonyms: SMX-NO
Research Areas:
Sulfamethoxazole-NO (SMX-NO) is a haptenizing immunogen. Sulfamethoxazole-NO reduces NF-kB signaling, induces AP-1 signaling, and depletes cysteine, glutathione, and ascorbic acid. Sulfamethoxazole-NO forms covalently haptenized proteins and antigens, activates MHC-restricted T cells and CD4 + T cells, and upregulates dendritic cell CD40. Sulfamethoxazole-NO induces apoptosis, necrosis, methemoglobin formation, and cytotoxicity accompanied by loss of membrane integrity. Sulfamethoxazole-NO inhibits neutrophil function and oxidative metabolism. Sulfamethoxazole-NO can be used for research on hypersensitivity reactions .
Cat. No.: HY-119681
CAS No.: 79889-39-7
Target:
Research Areas:
YM 11124 is an orally active selective immunosuppressive agent. YM 11124 can inhibit cell-mediated immune responses (type IV allergic reactions, such as delayed-type hypersensitivity and allogenic skin graft rejection) and type III allergic reactions (such as passive Arthus reaction). YM 11124 has no effect on type I, type II allergic reactions or acute inflammation. YM 11124 can be used in research related to organ transplantation and immune hypersensitivity .
Cat. No.: HY-136644A
CAS No.: 335458-65-6
Target:
Research Areas:
PD-217014 is an α2δ ligand with visceral analgesic activity and can inhibit visceral hypersensitivity reactions. Its anti-allodynic effect is dose-dependent.
Cat. No.: HY-137863
CAS No.: 69372-19-6
Target:
Research Areas:
Pemirolast is an orally active antiallergic agent. Pemirolast attenuates Paclitaxel (HY-B0015) hypersensitivity reactions. Pemirolast can be used for bronchial asthma and conjunctivitis research - .
Cat. No.: HY-13710AR
CAS No.: 3614-69-5
Research Areas:
Dimethindene (maleate) (Standard) is the analytical standard of Dimethindene (maleate). This product is intended for research and analytical applications. Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions .
Cat. No.: HY-N0856R
CAS No.: 26575-93-9
Synonyms: 23-O-Acetylalisol C (Standard); Alisol C monoacetate (Standard)
Category:
Alisma plantago-aquatica Linn. Extract Triterpenes Plant Terpenoids Alisma orinentale (Samuel.) Juz. Extract Alismataceae Extract
Target:
Cat. No.: HY-114348R
CAS No.: 5545-17-5
Synonyms: DiNAC (Standard); (Ac-Cys-OH)2 (Standard)
Research Areas:
N,N'-Diacetyl-L-cystine (Standard) is the analytical standard of N,N'-Diacetyl-L-cystine. This product is intended for research and analytical applications. N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .
Cat. No.: HY-163038
Synonyms: SMX-NO hydrate
Research Areas:
Sulfamethoxazole-NO hydrate (SMX-NO hydrate) is a haptenizing immunogen. Sulfamethoxazole-NO hydrate reduces NF-kB signaling, induces AP-1 signaling, and depletes cysteine, glutathione, and ascorbic acid. Sulfamethoxazole-NO hydrate forms covalently haptenized proteins and antigens, activates MHC-restricted T cells and CD4 + T cells, and upregulates dendritic cell CD40. Sulfamethoxazole-NO hydrate induces apoptosis, necrosis, methemoglobin formation, and cytotoxicity accompanied by loss of membrane integrity. Sulfamethoxazole-NO hydrate inhibits neutrophil function and oxidative metabolism. Sulfamethoxazole-NO hydrate can be used for research on hypersensitivity reactions .
Cat. No.: HY-118935
CAS No.: 666256-06-0
Target:
Research Areas:
NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension .
Cat. No.: HY-17484R
CAS No.: 99464-64-9
Synonyms: CP 65703 (Standard)
Target:
Research Areas:
Ampiroxicam (Standard) is the analytical standard of Ampiroxicam. This product is intended for research and analytical applications. Ampiroxicam is an orally active prodrug of non-steroidal anti-inflammatory drug (NSAID). Ampiroxicam inhibits paw swelling in adjuvant-induced arthritis and acute inflammation models, and suppresses phenylbenzoquinone-induced stretching responses in mice. Ampiroxicam is rapidly and completely converted to Piroxicam (HY-B0253) via non-specific esterases and first-pass metabolism. Ampiroxicam induces contact hypersensitivity and photosensitivity reactions through photoproducts generated by UVA. Ampiroxicam can be used in research related to photosensitivity, adjuvant-induced arthritis, rheumatism, osteoarthritis and other inflammatory diseases.
Cat. No.: HY-135082
CAS No.: 114438-33-4
Synonyms: Sulfamethoxazole hydroxylamine
Target:
Research Areas:
N-Hydroxy sulfamethoxazole (Sulfamethoxazole hydroxylamine) is a Sulfamethoxazole (HY-B0322) metabolite formed by CYP2C9 oxidation that oxidizes hemoglobin to methemoglobin. N-Hydroxy sulfamethoxazole induces haptenation on the surface of viable leukocytes, neutrophil apoptosis, and inhibits neutrophil function. N-Hydroxy sulfamethoxazole is associated with hypersensitivity reactions and can be used in the study of hypersensitivity reactions .
Target:
Research Areas:
Pyrazinobutazone (Phenylbutazone piperazium) is an antipyrene derivative that possesses anti-inflammatory properties and has been associated with hypersensitivity reactions leading to agranulocytosis and liver injury.
Cat. No.: HY-165564
CAS No.: 113759-19-6
Target:
Research Areas:
SM-8849 is a thiazole derivative with anti-arthritis activity. SM-8849 specifically targets and inactivates T cells involved in delayed-type hypersensitivity (DTH) reactions, thereby inhibiting the core immunopathological process of arthritis, but has little effect on the humoral immune process such as antibody production. In a mouse arthritis model induced by Type II Collagen (HY-NP003), SM-8849 significantly alleviated clinical symptoms, reduced bone destruction and joint damage. SM-8849 can be used for the study of autoimmune diseases such as rheumatoid arthritis .
Furazolium hydrochloride is a broad-spectrum antibacterial agent with inhibitory activity against a variety of Gram-positive and Gram-negative Bacterial strains. In a gelatin-acacia complex coacervate system, Furazolium hydrochloride exhibits protein-binding properties, where protein binding dominates at low concentrations, while micellization occurs at high concentrations. Furazolium hydrochloride does not alter the water permeability of cellulose membranes, and it can induce delayed-type hypersensitivity reactions in guinea pigs, with cross-reactivity observed in animals sensitized with aflatoxin B1. Furazolium hydrochloride can be used in studies related to bacterial infections and local wound infections .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
