2 Results for "

iNOS/ICAM-1

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "iNOS/ICAM-1" in MCE Product Catalog:

Casuarinin
Casuarinin
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Cat. No.: HY-N12717
CAS No.: 79786-01-9
Category:  

Terminalia arjuna (Roxb. ex DC.) Wight & Arn. Extract Plant Combretaceae Extract Phenols Polyphenols

Target:  

PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis

Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO-1, mFasL, sFasL and HSP-70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF-α-induced phosphorylation of MAPK and activation of NF-κB, downregulates the expression of iNOS, NF-κB, COX-2 and ICAM-1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase-3 and elevation of TNF-α, inhibits the growth of Candida albicans, and inhibits HSV-2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .
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Aloenin aglycone
Aloenin aglycone
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Cat. No.: HY-N11996
CAS No.: 59163-53-0
Category:  

Plant Aloe vera (L.) Burm. f. Extract Phenols Polyphenols Liliaceae Extract

Target:  

NO Synthase NF-κB

Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .
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