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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
iNOS-IN-2
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "iNOS-IN-2" in MCE Product Catalog:
Cat. No.: HY-146309
CAS No.: 2419891-42-0
Target:
Research Areas:
iNOS-IN-2 (Compound 53) is a potent down-regulator of inducible nitric oxide synthase (iNOS) protein. iNOS-IN-2 effectively inhibits the NO production (IC50=6.4 μM). iNOS-IN-2 has a potential therapeutic effect on chronic inflammation .
9
Category:
Triterpenes Plant Terpenoids Disease Research Fields Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Extract Cancer Araliaceae Extract
Target:
7
7 Cited Publications
Cat. No.: HY-N0631
CAS No.: 131189-57-6
6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
4
Category:
Plant Phenols Polyphenols Compositae/Asteraceae Extract Disease Research Fields Bidens pilosa Extract Inflammation/Immunology Cancer
Target:
3
3 Cited Publications
Cat. No.: HY-N0569
CAS No.: 18449-41-7
3
3 Cited Publications
Cat. No.: HY-170621
CAS No.: 2958649-56-2
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
STAT1/3-IN-1 is a potent STAT1/3 inhibitor with potent anti-inflammatory effect. STAT1/3-IN-1 inhibits phosphorylation and nuclear translocation of STAT1/3 to modulate microglial inflammation, reduces LPS (HY-D1056)-induced pro-inflammatory cytokines (NO, IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS, COX-2). STAT1/3-IN-1 exhibits low toxicity in mice. STAT1/3-IN-1 can be used for the research of neuroinflammation .
2
2 Cited Publications
Research Areas:
K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-κB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IκB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury [2] .
2
2 Cited Publications
Cat. No.: HY-N1921
CAS No.: 32685-93-1
2
1
1 Cited Publications
Synonyms: (-)-ProcyanidIN B4
1
1 Cited Publications
Cat. No.: HY-N0569R
CAS No.: 18449-41-7
Cat. No.: HY-W010066
CAS No.: 28822-73-3
Category:
Metabolic Disease Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Disease markers Phenols Polyphenols Nervous System Disorder Microorganism Disease Research Fields
Target:
Cat. No.: HY-N7630
CAS No.: 135447-39-1
Category:
Plant Ketones, Aldehydes, Acids Scrophulariaceae Extract Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Extract Disease Research Fields Inflammation/Immunology
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Target:
Research Areas:
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research .
Cat. No.: HY-N3848
CAS No.: 20869-95-8
Category:
Cardiovascular Disease Flavonols Curcuma phaeocaulis Valeton Extract Zingiberaceae Extract Plant Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-N3480
CAS No.: 53319-52-1
Synonyms: (+)-Isogospherol; Isogospherol
Category:
Umbelliferae/Apiaceae Extract Plant Heracleum rapula Franch. Extract Coumarins Phenylpropanoids
Target:
Category:
Triterpenes Plant Terpenoids Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Extract Araliaceae Extract
Target:
Cat. No.: HY-151921
CAS No.: 2816993-09-4
Target:
Research Areas:
Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
