Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
ion flux
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "ion flux" in MCE Product Catalog:
53
53 Publications Verification
Synonyms: MK-801
Target:
Research Areas:
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux .
5
5 Cited Publications
Target:
Research Areas:
A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux .
5
5 Cited Publications
Cat. No.: HY-15568A
Purity: 99.88%
Target:
Research Areas:
A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 sodium salt hydrate is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 sodium salt hydrate reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux .
1
1 Cited Publications
Synonyms: TRPC6-IN-3
Target:
Research Areas:
Apecotrep (TRPC6-IN-3) (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. Apecotrep modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. Apecotrep can be used in research of respiratory system .
Target:
Research Areas:
APOL1-IN-1 is an apolipoprotein L1 (APOL1) inhibitor that suppresses the functional activity of the APOL1 G1 risk variant. APOL1-IN-1 inhibits the pore function of APOL1, thereby reducing APOL1-mediated membrane permeability and abnormal ion flux, and thus intervenes in APOL1-related cellular injury processes. APOL1-IN-1 is used in research related to focal segmental glomerulosclerosis and non-diabetic kidney disease .
Cat. No.: HY-158741
CAS No.: 1369302-24-8
Synonyms: APG-2 Acetoxymethyl ester
Cat. No.: HY-117804
CAS No.: 151898-26-9
Synonyms: 8-Bromo-Cyclic ADP-Ribose
Target:
Research Areas:
8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) is a membrane-permeable competitive antagonist of Cyclic ADP-ribose (cADPR) (HY-N7395) and an antagonist of TRPM2 ion channels. 8-Br-cADPR blocks cADPR-dependent RyR, SR calcium mobilization, and cADPR-mediated signaling; reduces Paclitaxel (HY-B0015)-induced axonal calcium flux, and protects against Paclitaxel-induced axonal degeneration/peripheral neuropathy. 8-Br-cADPR blocks isoproterenol-induced pulmonary artery dilation, angiotensin II-induced arterial calcium signaling/contraction, and hypoxic pulmonary vasoconstriction. 8-Br-cADPR can be used in research related to neurological diseases and cancer .
Cat. No.: HY-175081
Synonyms: 8-Bromo-Cyclic ADP-Ribose sodium salt
Target:
Research Areas:
8-Br-cADPR sodium salt (8-Bromo-Cyclic ADP-Ribose sodium salt) is a membrane-permeable competitive antagonist of Cyclic ADP-ribose (cADPR) (HY-N7395) and an antagonist of TRPM2 ion channels. 8-Br-cADPR sodium salt blocks cADPR-dependent RyR, SR calcium mobilization, and cADPR-mediated signaling; reduces Paclitaxel (HY-B0015)-induced axonal calcium flux, and protects against Paclitaxel-induced axonal degeneration/peripheral neuropathy. 8-Br-cADPR sodium salt blocks isoproterenol-induced pulmonary artery dilation, angiotensin II-induced arterial calcium signaling/contraction, and hypoxic pulmonary vasoconstriction. 8-Br-cADPR sodium salt can be used in research related to neurological diseases and cancer .
Cat. No.: HY-121366
CAS No.: 58769-20-3
Synonyms: RU-15525
Target:
Research Areas:
Kadethrin is a synthetic pyrethroid that acts as an insecticide. Kadethrin can affect the binding of [3H] full-histamine toxin ([3H]H12-HTX) to the nicotinic acetylcholine (Ach) receptor/channel binding sites, and it inhibits the Ca 2+ flux through the receptor ion channels .
Cat. No.: HY-113232S
CAS No.: 1276197-31-9
Research Areas:
3-Methylcrotonylglycine-d2 is the deuterated-labeled 3-Methylcrotonylglycine (HY-113232). 3-Methylcrotonylglycine is an organic acid conjugate associated with leucine catabolism that inhibits respiratory chain complex II-III, mitochondrial creatine kinase, and synaptic membrane Na +, K +-ATPase. 3-Methylcrotonylglycine increases reactive oxygen species levels to mediate oxidative damage, while inhibiting mitochondrial electron transport, reducing tricarboxylic acid cycle flux, and interfering with intracellular energy transport and neuronal ion homeostasis. 3-Methylcrotonylglycine is a neurotoxic metabolite that accumulates in the metabolic pathway of 3-methylcrotonyl-CoA carboxylase deficiency. 3-Methylcrotonylglycine can be used in studies related to 3-methylcrotonyl-CoA carboxylase deficiency .
Cat. No.: HY-15084BR
CAS No.: 77086-21-6
Synonyms: MK-801 (Standard)
Target:
Research Areas:
Dizocilpine (Standard) is the analytical standard of Dizocilpine (HY-15084B). This product is intended for research and analytical applications. Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux .
Cat. No.: HY-181007
Target:
Research Areas:
NMDA receptor antagonist 9 is a selective GluN2B subunit-containing NMDA receptor antagonist with a Ki of 5.2 nM. NMDA receptor antagonist 9 exhibits 9-fold selectivity over σ1 receptors, shows poor selectivity towards σ2 receptors. NMDA receptor antagonist 9 inhibits ion flux through GluN2B subunit-containing NMDA receptors. NMDA receptor antagonist 9 can be used for the research of neurological disease, such as alzheimer’s disease and parkinson’s disease .
Cat. No.: HY-N20708
CAS No.: 89353-99-1
Target:
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
