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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
ionic homeostasis
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "ionic homeostasis" in MCE Product Catalog:
Cat. No.: HY-189740
CAS No.: 3127776-54-6
Research Areas:
nAChR-IN-3 is an nAChR α6 subunit inhibitor and broad-spectrum insecticide against Acyrthosiphon pisum, Nilaparvata lugens, and Bemisia tabaci. nAChR-IN-3 acts through the nicotinic acetylcholine receptor α6 subunit; α6 silencing increases aphid tolerance and α6-null Drosophila show high-level resistance. nAChR-IN-3 disrupts ionic homeostasis and cholinergic signaling in nerve cells. nAChR-IN-3 induces mitochondrial electron transport chain disruption and reactive oxygen species burst. nAChR-IN-3 inhibits ATP synthesis and collapses energy metabolism. nAChR-IN-3 shows low toxicity to non-target honeybees, zebrafish, and earthworms and no inhibition of crop seed germination or seedling development. nAChR-IN-3 displays cytotoxicity in human keratinocytes and renal cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
