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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
isoelectric points
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "isoelectric points" in MCE Product Catalog:
Cat. No.: HY-159648
CAS No.: 2936625-34-0
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PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats .
Synonyms: INT131
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AMG131 (INT131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 is promising for research of type-2 diabetes mellitus .
Cat. No.: HY-161169A
CAS No.: 2865106-78-9
TP0628103 TFA is a potent and highly selective MMP-7 inhibitor with an IC50 of 0.17 nM. TP0628103 TFA undergoes structural optimization via molecular isoelectric point shifting, which reduces organic anion transporter (OAT)-mediated clearance, while maintaining potent MMP-7 inhibitory activity and enhancing MMP subtype selectivity. TP0628103 TFA is applicable for research on the regulatory mechanisms of MMP-7-related matrix metalloproteinases .
Cat. No.: HY-116392E
CAS No.: 109836-82-0
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D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP can be used to study diseases related to targeted glycosphingolipid metabolism .
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D-threo-PDMP hydrochloride is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP hydrochloride inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP hydrochloride inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP hydrochloride can be used to study diseases related to targeted glycosphingolipid metabolism .
Cat. No.: HY-161169
CAS No.: 2865102-08-3
TP0628103 is a potent and highly selective MMP-7 inhibitor with an IC50 of 0.17 nM. TP0628103 undergoes structural optimization via molecular isoelectric point shifting, which reduces organic anion transporter (OAT)-mediated clearance, while maintaining potent MMP-7 inhibitory activity and enhancing MMP subtype selectivity. TP0628103 is applicable for research on the regulatory mechanisms of MMP-7-related matrix metalloproteinases .
Cat. No.: HY-W591402
CAS No.: 2434639-17-3
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3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
Cat. No.: HY-151766
CAS No.: 2109751-68-8
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DACN(Tos,Suc-OH) is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. DACNs possess high thermal and chemical stability along with comparable click reactivity .
Cat. No.: HY-121158
CAS No.: 36335-67-8
Synonyms: S-2846
Butamifos (S-2846) is an organophosphoramidate herbicide used to control annual weeds with low toxicity to mammals. Butamifos acts on the growing points of susceptible plants, causing severe radial enlargement of the affected tissues .
Cat. No.: HY-134460
CAS No.: 54322-38-2
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Cat. No.: HY-117103A
CAS No.: 849738-78-9
Synonyms: INT131 benzenesulfonate
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AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus .
Cat. No.: HY-151754
CAS No.: 2109751-74-6
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DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity . DACN(Tos2,6-OH) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-121158R
CAS No.: 36335-67-8
Synonyms: S-2846 (Standard)
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Butamifos (Standard) is the analytical standard of Butamifos. This product is intended for research and analytical applications. Butamifos (S-2846) is an organophosphoramidate herbicide used to control annual weeds with low toxicity to mammals. Butamifos acts on the growing points of susceptible plants, causing severe radial enlargement of the affected tissues .
Cat. No.: HY-189604
CAS No.: 2927390-43-8
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RNA splicing modulator 7 is an RNA splicing modulator. RNA splicing modulator 7 modulates mRNA splicing by targeting cis-elements of primary RNA transcripts (such as splice sites, branch points, splicing enhancers, or splicing silencers). RNA splicing modulator 7 has anticancer activity against leukemia .
Cat. No.: HY-P11861
Research Areas:
Cat. No.: HY-L0088V
50,240 compounds
Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
