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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
isoxazole
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "isoxazole" in MCE Product Catalog:
Cat. No.: HY-W010649
CAS No.: 288-14-2
Target:
HSP Epigenetic Reader Domain ATP-binding cassette (ABC) transporters Bacterial Fungal Antibiotic
Research Areas:
Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor .
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12 Publications Verification
Synonyms: isoxazole 9
Target:
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ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca 2+ influx through both voltage-gated Ca 2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) .
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VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events .
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1 Cited Publications
MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .
Cat. No.: HY-W750960
CAS No.: 1377605-22-5
Biotinylated isoxazole is a chemical probe that selectively precipitates proteins containing prion-like low-complexity domains and Cross-β prion-like polymers through recognition of Cross-β structure. Biotinylated isoxazole induces precipitation of proteins containing intrinsically disordered regions through microcrystal formation in solution. Biotinylated isoxazole enables enrichment of Amyloid oligomers for ELISA-based detection. Biotinylated isoxazole decreases Gems and increases misfolded PFN1 aggregates .
Cat. No.: HY-100696
CAS No.: 1629277-36-6
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PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4(1) .
Cat. No.: HY-W984122
CAS No.: 912790-04-6
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CFTR corrector 17 is an isoxazole compound and CFTR modulator. CFTR corrector 17 can be used for the research of cystic fibrosis .
Cat. No.: HY-12323G
CAS No.: 832115-62-5
Synonyms: isoxazole 9 (GMP)
Cat. No.: HY-133128
CAS No.: 2407981-35-3
FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .
Cat. No.: HY-W023983
CAS No.: 611-91-6
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Chalcone dibromide is an effective synthetic compound for the synthesis of numerous bioactive molecules such as pyrazoles, hydroxypyrazoles, and isoxazoles. Chalcone dibromide has antioxidant effects and acts against tumor cells by inhibiting superoxide production and lipid peroxidation. Chalcone dibromide can be used in research on cancer-related diseases .
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TP748,an isoxazole, is a key intermediate for fully synthetic tetracyclines .
Cat. No.: HY-W010649R
CAS No.: 288-14-2
Target:
HSP Reference Standards Epigenetic Reader Domain ATP-binding cassette (ABC) transporters Bacterial Fungal Antibiotic
Research Areas:
Isoxazole (Standard) is the analytical standard of Isoxazole (HY-W010649). This product is intended for research and analytical applications. Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor? .
Cat. No.: HY-W750960R
CAS No.: 1377605-22-5
Biotinylated isoxazole (Standard) is the analytical standard of Biotinylated isoxazole (HY-W750960). This product is intended for research and analytical applications. Biotinylated isoxazole is a chemical probe that selectively precipitates proteins containing prion-like low-complexity domains and Cross-β prion-like polymers through recognition of Cross-β structure. Biotinylated isoxazole induces precipitation of proteins containing intrinsically disordered regions through microcrystal formation in solution. Biotinylated isoxazole enables enrichment of Amyloid oligomers for ELISA-based detection. Biotinylated isoxazole decreases Gems and increases misfolded PFN1 aggregates .
Cat. No.: HY-167644
CAS No.: 36920-48-6
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Research Areas:
Cefoxazole is a β-lactam antibiotic containing an isoxazole moiety and exhibits antibacterial activity. Cefoxazole can be used in studies related to infectious diseases .
Cat. No.: HY-120611A
CAS No.: 1265323-40-7
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BMS-960 is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases .
Cat. No.: HY-120611
CAS No.: 1265321-86-5
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BMS-960 free base is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases .
Cat. No.: HY-155722
CAS No.: 2954888-39-0
Mtb-IN-5 (compound (-)17j) is an isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity. Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .
Cat. No.: HY-155720
CAS No.: 2306039-13-2
Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .
Cat. No.: HY-173355
CAS No.: 3052630-27-7
RCB18350 is an antituberculosis agent that belongs to the class of isoxazole derivatives. RCB18350 has bacteriostatic activity and inhibits the growth of Mycobacterium tuberculosis with an MIC of 1.25 μg/mL. RCB18350 is effective against multidrug-resistant Mycobacterium tuberculosis (MDR-TB) clinical isolates, slow-growing mycobacteria such as Mycobacterium bovis BCG and Mycobacterium avium .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
