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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
169 Results for "
keratinocyte
" in MedChemExpress (MCE) Product Catalog:
Products (169)
169 Results for "keratinocyte" in MCE Product Catalog:
8
8 Publications Verification
Target:
Research Areas:
GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes .
8
8 Publications Verification
Synonyms: SKF 29044
Target:
Parbendazole (SKF‑29044) is an orally active benzimidazole carbamate compound with multiple biological activities. Parbendazole binds to free tubulin and inhibits microtubule polymerization; it also activates the JNK/c‑Jun signaling axis and upregulates the expression of the downstream axonal repulsion factor Sema3A. Parbendazole upregulates KAL-1 mRNA expression, reduces nerve growth factor levels, and promotes the terminal differentiation of normal human epidermal keratinocytes. Parbendazole induces apoptosis in differentiated acute myeloid leukemia monocytes and exerts antileukemic activity in a mouse xenograft model of acute myeloid leukemia. Parbendazole exhibits broad-spectrum anthelmintic activity against various animal nematodes. Parbendazole is used in research related to acute myeloid leukemia and parasitic infections .
5
5 Cited Publications
Cat. No.: HY-P70597
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF7; HBGF-7; Fibroblast Growth Factor 7; FGF-7; KGF; Fibroblast Growth Factor 7 (keratinocyte Growth Factor); keratinocyte Growth Factor; Fibroblast Growth Factor; Heparin-Binding Growth Factor 7; FGF
Species:
Human
Source:
E. coli
5
5 Cited Publications
Cat. No.: HY-P7170
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By Fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:
Mouse
Source:
E. coli
4
4 Cited Publications
Research Areas:
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research .
3
3 Cited Publications
Cat. No.: HY-W028393
CAS No.: 392-12-1
2
2 Cited Publications
Cat. No.: HY-W050154
CAS No.: 501-30-4
Category:
Infection Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Microorganism Endogenous metabolite Disease Research Fields
Target:
2
2
2 Cited Publications
Cat. No.: HY-P7048
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By Fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P0170
CAS No.: 885340-08-9
Target:
Research Areas:
1
1 Cited Publications
Synonyms: L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats .
1
1 Cited Publications
Cat. No.: HY-P9947
CAS No.: 214745-43-4
1
1 Cited Publications
Cat. No.: HY-NP199
1
1 Cited Publications
Synonyms: Hexahydroadiphenine hydrochloride
Target:
Cholinesterase (ChE) Potassium Channel Amyloid-β TRP Channel Tau Protein NOD-like Receptor (NLR) JNK NF-κB IKK
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Drofenine (Cycloadiphene; Hexahydroadiphenine) hydrochloride is an brain-penetrant antispasmodic agent. Drofenine hydrochloride is a Kv2.1 channel inhibitor with human IC50 of 9.53 μM. Drofenine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with Ki of 0.003 mM, and is a TRPV3 activator. Drofenine hydrochloride blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial NLRP3 inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine hydrochloride induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine hydrochloride ameliorates diabetic peripheral neuropathy -like pathology. Drofenine hydrochloride can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm .
1
Category:
Triterpenes Plant Terpenoids Poria cocos Extract Polyporaceae Extract Disease Research Fields Inflammation/Immunology
Target:
1
1
1 Cited Publications
Cat. No.: HY-P7176
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF7; HBGF-7; Fibroblast Growth Factor 7; FGF-7; KGF; Fibroblast Growth Factor 7 (keratinocyte Growth Factor); keratinocyte Growth Factor; Fibroblast Growth Factor; Heparin-Binding Growth Factor 7; FGF
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P70673
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FGF7; HBGF-7; Fibroblast Growth Factor 7; FGF-7; KGF; Fibroblast Growth Factor 7 (keratinocyte Growth Factor); keratinocyte Growth Factor; Fibroblast Growth Factor; Heparin-Binding Growth Factor 7; FGF
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P700279
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By Fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P7342AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By Fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
