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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
malonylation
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "malonylation" in MCE Product Catalog:
2
2 Cited Publications
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Research Areas:
malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation .
Cat. No.: HY-W283726
CAS No.: 141-95-7
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Sodium malonate is an inhibitor of succinate dehydrogenase (SDH) and can interfere with the TCA cycle. Sodium malonate can act as an AcrAB‑TolC efflux pump inhibitor, blocking multidrug efflux processes in bacteria and enhancing the efficacy of antibiotics. Sodium malonate can be converted to malonyl‑CoA, which mediates protein lysine malonylation, relieves the transcriptional repression effect of STAT6, upregulates TCF1 protein expression, and thereby promotes CD8 + T cell memory differentiation. Sodium malonate can stimulate ovarian steroidogenesis in immature rats, increasing ovarian and uterine weights and ovarian cholesterol production. Sodium malonate can inhibit brain ATP production, leading to energy deficiency, neuronal glutamate accumulation, and excitotoxic striatal lesions. Sodium malonate can be used in research on metabolism-related diseases, immune-related diseases, and bacterial infections, and can also serve as an intermediate for research related to organic synthesis .
Cat. No.: HY-P3788
CAS No.: 168135-79-3
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
