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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
nanoparticle uptake
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "nanoparticle uptake" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P1848
CAS No.: 395069-86-0
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1
1 Cited Publications
Cat. No.: HY-W127512
CAS No.: 546-18-9
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5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
Cat. No.: HY-W008034
CAS No.: 143824-78-6
Synonyms: Fmoc-L-Trp(Boc)-OH
Cat. No.: HY-P4121
CAS No.: 1898254-09-5
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Cat. No.: HY-P5287
CAS No.: 393781-65-2
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cRGDfK-thioacetyl ester is a selective αvβ3 integrin-binding peptide that mediates cellular uptake through integrins overexpressed on tumor cells. cRGDfK-thioacetyl ester is conjugated to maleimide-functionalized PLGA nanoparticles, which enhances nanoparticle uptake and improves accumulation and retention. cRGDfK-thioacetyl ester can be used in research related to tumor-targeted nanodelivery and cancer-targeted imaging .
Cat. No.: HY-W440986
CAS No.: 321595-13-5
Synonyms: DSPS sodium
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Distearoylphosphatidylserine (DSPS) sodium is an anionic phospholipid. Distearoylphosphatidylserine sodium possesses both a hydrophilic head group and a hydrophobic tail, enabling it to self-assemble in aqueous phases to form stable lipid bilayer structures. Distearoylphosphatidylserine sodium promotes uptake by phagocytes and participates in the endosomal escape of lipid nanoparticles (LNPs) within cells. Distearoylphosphatidylserine sodium can be used in research on the construction of lipid nanoparticles for targeted delivery of siRNA (for immune or anti-inflammatory therapy), as well as the preparation of ultrasound contrast microbubbles for molecular imaging .
Cat. No.: HY-170704
CAS No.: 1480940-53-1
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DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .
Cat. No.: HY-168943
Cat. No.: HY-D2794A
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FITC-PEG1000-NH2 is a non-membrane-permeable fluorescent dye, which is a fluorescently labeled polyethylene glycol derivative with an amine terminal group. FITC-PEG1000-NH2 cannot enter cancer cells, and can be used to prepare FITC-loaded solid lipid nanoparticles for macrophage uptake studies. FITC-PEG1000-NH2 can also be used to label polymers for cell uptake studies .
Cat. No.: HY-P10997
CAS No.: 536971-53-6
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F3 peptide is a nucleolin-binding tumor-homing peptide that mediates selective uptake and internalization by tumor cells. F3 peptide is a 31-amino acid fragment of human high mobility group nucleosomal protein 2 (HMGN2). F3 peptide inhibits protein synthesis through ribosome inactivation. F3 peptide targets the tumor vasculature. F3 peptide can serve as an effective ligand to improve the druggability of macromolecular drugs or nanoparticles. F3 peptide is used in research on cancers such as glioblastoma and breast cancer .
Cat. No.: HY-W1113135
CAS No.: 2828447-14-7
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Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba 2+, Ca 2+, Cd 2+, Ni 2+, Pb 2+, Sr 2+, and Zn 2+ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research .
Cat. No.: HY-P5287A
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cRGDfK-thioacetyl ester TFA is a selective αvβ3 integrin-binding peptide that mediates cellular uptake through integrins overexpressed on tumor cells. cRGDfK-thioacetyl ester TFA is conjugated to maleimide-functionalized PLGA nanoparticles, which enhances nanoparticle uptake and improves accumulation and retention. cRGDfK-thioacetyl ester TFA can be used in research related to tumor-targeted nanodelivery and cancer-targeted imaging .
Cat. No.: HY-168943A
Cat. No.: HY-168943B
Cat. No.: HY-168943C
Cat. No.: HY-W010713
CAS No.: 2669-65-0
Synonyms: Fimaporfin free base
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Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with poor water solubility, which limits its use in the blood circulation. However, TPCS2a@NPs nanoparticles can be prepared based on polylactic-co-polyethylene glycol acid (PLGA) polymer core loaded with TPCS2. Such nanoparticles can be coated with mesenchymal stem cell-derived plasma membranes (mMSCs) to form mMSC-TPCS2a@NPs, which prolongs blood circulation time and improves tumor targeting ability. Compared with uncoated TPCS2a@NPs, mMSC-TPCS2a@NPs can reduce macrophage uptake by 54% to 70% under different conditions. Both nanoparticle forms are effectively accumulated in MCF7 and MDA-MB-231 breast cancer cells, while uptake in normal breast epithelial cells MCF10A is significantly lower .
Cat. No.: HY-162828
STAT3/HDAC-IN-2 (compound 18) is a dual inhibitor of STAT3 and HDAC, inducing autophagy and apoptosis. STAT3/HDAC-IN-2 is an amphiphilic hydroxamic acid hybrid based on the natural product isopropanol lactone (IAL) and is a nanoscale anticancer agent. STAT3/HDAC-IN-2 can self-assemble in water to form nanoparticles, which have higher tumor tissue accumulation, cellular uptake and anticancer properties compared to the free state .
Cat. No.: HY-W008034S
CAS No.: 1325307-52-5
Synonyms: Fmoc-L-Trp(Boc)-OH-13C11,15N2
Cat. No.: HY-P11918
CAS No.: 2350190-98-4
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D-T7 is a transferrin receptor (TfR) binding peptide that mediates brain-targeted delivery. D-T7 acts as a penetration enhancer and uptake promoter for nanoparticles in glioma tissues and target cells. D-T7 can be used in glioma research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
