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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
nitrite production
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "nitrite production" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N4099
CAS No.: 53527-42-7
Category:
Plant Flavonoids Flavones Phenols Polyphenols Other Families Extract Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-131521
CAS No.: 89304-26-7
Synonyms: Oxalomalate trisodium
Target:
Research Areas:
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .
Category:
Triterpenes Plant Terpenoids Euphorbia boetica Extract Disease Research Fields Inflammation/Immunology Euphorbiaceae Extract
Target:
Cat. No.: HY-W019334
CAS No.: 202842-98-6
Synonyms: 3,4-DMPP
3,4-Dimethylpyrazole phosphate (3,4-DMPP) is a nitrification inhibitor and microbial community regulator, whose activity is dose- and soil pH-dependent. 3,4-Dimethylpyrazole phosphate inhibits ammonia monooxygenase, ammonia-oxidizing bacteria, as well as ammonia-oxidizing archaea and nitrite-oxidizing bacteria. 3,4-Dimethylpyrazole phosphate alters the community composition of prokaryotes, fungi and ammonia-oxidizing bacteria. 3,4-Dimethylpyrazole phosphate reduces nitrate leaching, nitrous oxide emission and soil nitrate accumulation, and enhances nitrogen use efficiency and crop yield in agricultural production. 3,4-Dimethylpyrazole phosphate is applicable to agriculture-related research .
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Guanidino ethyl disulfide (GED) (Compound 23) is a NO Synthase (NOS) inhibitor with EC50s of 110, 630 and 180 μM for iNOS, eNOS and bNOS, respectivly. Guanidino ethyl disulfide effectively inhibits nitrite production in J774.2 macrophages. Guanidino ethyl disulfide can be used for circulatory shock, inflammation and neurological diseases research .
Cat. No.: HY-105023
CAS No.: 74436-00-3
Research Areas:
Cyclosporin G is a cyclic peptide analog of Cyclosporin A (HY-B0579) metabolized by CYP3A4, and is an immunosuppressant. Cyclosporin G inhibits interleukin-1β-induced NO synthase expression/nitrite production and inhibits insulin release from isolated human pancreatic islets. Cyclosporin G is cytotoxic to hepatoblastoma cells and induces intracellular calcium elevation and necrosis. Cyclosporin G inhibits P-glycoprotein-mediated dye efflux. Cyclosporin G can be used in research on psoriasis and multiple myeloma .
Cat. No.: HY-118160
CAS No.: 65240-86-0
Synonyms: NSC 73233
Target:
NO Synthase Drug Derivative IKK NF-κB HDAC Reactive Oxygen Species (ROS) AMPK mTOR PI3K Akt Autophagy Apoptosis
Research Areas:
Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
PPM-18 (NSC 73233) is a Vitamin K (HY-B2172) analog. PPM-18 prevents LPS-induced IκBα degradation, thereby inhibiting NF-κB activation and nuclear translocation of NF-κB. PPM-18 inhibits LPS-induced nitrite production and iNOS expression. PPM-18 inhibits HDAC6. PPM-18 induces ROS accumulation, activates AMPK, inhibits the mTORC1 and PI3K/AKT pathways, initiates Autophagy, and induces Apoptosis. PPM-18 suppresses seizures in zebrafish and mouse epilepsy models. PPM-18 prevents LPS-induced lethal toxicity and delayed hypotension. PPM-18 exhibits anticancer activity against leukemia and bladder cancer. PPM-18 can be used in research related to septic shock, bladder cancer and atherosclerosis .
Cat. No.: HY-139068
CAS No.: 57469-82-6
Target:
Drug Derivative Reactive Oxygen Species (ROS) NO Synthase TNF Receptor Interleukin Related STAT PERK Bacterial
Research Areas:
Ibuprofen arginine is an orally active L-arginine salt of Ibuprofen (HY-78131). Ibuprofen arginine inhibits COX-2-dependent PGE2 production, inhibits iNOS and NOX-2, and reduces pro-inflammatory mediators, nitrite, ROS, oxidative stress, and cytokine secretion. Ibuprofen arginine inhibits ERK1/2 and STAT3 phosphorylation and attenuates M1 polarization. Ibuprofen arginine can serve as a substrate to provide L-arginine to support iNOS-mediated nitrite production and eNOS-mediated NO release, reversing NOS inhibitor-induced dysfunction and L-NAME (HY-18729)-induced contraction. Ibuprofen arginine alleviates joint inflammation and has antibacterial activity. Ibuprofen arginine can be used in research on inflammation-related diseases and pain .
Cat. No.: HY-N0577R
CAS No.: 26544-34-3
Synonyms: Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)
Category:
Umbelliferae/Apiaceae Extract Plant Flavonoids Flavones Apium graveliens L. Extract Phenols Polyphenols
Target:
Cat. No.: HY-172786
CAS No.: 1984421-81-9
Research Areas:
Caspase-3-IN-3 (compound 7) is a caspase 3 inhibitor. Caspase-3-IN-3 increases cellular ATP levels, inhibits caspase-3 activity, decreases nitrite production, suppresses cytokine-induced apoptosis, and restores Glucose (HY-B0389)-stimulated insulin secretion .
Cat. No.: HY-N4099R
CAS No.: 53527-42-7
Target:
Cat. No.: HY-177050
CAS No.: 1199222-56-4
Research Areas:
RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly outperforming Betulinic acid (HY-10529) (EC50 = 1.04 μM). RG-239 demonstrates higher selectivity for TGR5 compared to the FXRα. RG-239 increases mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. RG-239 inhibits LPS (HY-D1056)-induced iNOS expression and nitrite production in Raw264.7 and microglia cells. RG-239 can be used for the study of type 2 diabetes [1][2][3][4][5].
Cat. No.: HY-183692
CAS No.: 3061938-00-6
Target:
FXR G protein-coupled Bile Acid Receptor 1 TNF Receptor Heme Oxygenase (HO) Quinone Reductase Keap1-Nrf2
Research Areas:
FXR agonist 18 is an orally active FXR agonist, with an EC50 of 10 nM against human FXR and an EC50 of 1360 nM against human TGR5. FXR agonist 18 inhibits inflammatory responses by reducing nitrite production, downregulating the expression of pro-inflammatory genes (Tnf, Adgre1, Cyp8b1, upregulating the expression of FXR, Hmox1, Nqo1, Nrf2, and enhancing antioxidant responses. FXR agonist 18 ameliorates liver fibrosis in mice, exhibits protective effects in mice with cholestatic liver injury, and shows anti-MASH efficacy. FXR agonist 18 can be used in studies of metabolic dysfunction-associated steatohepatitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
