Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
oligomer stabilization
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "oligomer stabilization" in MCE Product Catalog:
Cat. No.: HY-N12060
CAS No.: 90045-36-6
Cat. No.: HY-W010041
CAS No.: 488-59-5
Category:
Target:
Cat. No.: HY-13325
CAS No.: 71939-12-3
Target:
Research Areas:
Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD) .
Cat. No.: HY-W010041R
CAS No.: 488-59-5
Category:
Target:
Cat. No.: HY-W707693
CAS No.: 115268-26-3
Cat. No.: HY-D3573
Target:
Research Areas:
AF488 C5 Maleimide is a thiol-reactive Fluorescent dye used to label target proteins and bacterial structures. AF488 C5 Maleimide irreversibly forms covalent thioether conjugates with cysteine thiol groups. AF488 C5 Maleimide stabilizes pre-formed globular low-molecular-weight Tau protein oligomers by blocking cysteine-dependent tau protein aggregation, allowing observation of the internalization process of tau protein oligomers into neuronal cells via confocal microscopy. AF488 C5 Maleimide can label cysteine-modified pili; the outer membrane permeability varies among different bacterial species, allowing imaging via epifluorescence microscopy using a FITC filter set .
Cat. No.: HY-190530
CAS No.: 2891801-74-2
Research Areas:
HDAC6-IN-88 is a selective HDAC6 inhibitor with an IC50 of 28 nM. HDAC6-IN-88 directly binds to HDAC6 and prevents the deacetylation of α-tubulin (α-tubulin) and Hsp90. HDAC6-IN-88 enhances microglial phagocytosis, promotes microtubule stabilization, and inhibits NF-κB pathway activation. DAC6-IN-88 ameliorates cognitive deficits in Aβ1-42 oligomer-induced mice, reverses HDAC6-related changes in hippocampal biomarkers, and exhibits good biosafety. HDAC6-IN-88 can be used for research related to Alzheimer's disease .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
