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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
osteoblast function
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "osteoblast function" in MCE Product Catalog:
Research Areas:
Schizophyllan (SPG) is an orally active extracellular β-glucan produced by the fungus Schizophyllum commune. Schizophyllan improves mitochondrial function and protects against metabolic liver injury by activating the SIRT3 pathway. Schizophyllan inhibits osteoclastogenesis and promotes osteoblast differentiation by suppressing the phosphorylation of JNK/p38, as well as downregulating PGC1β/PPARγ, c-Fos and NFATc1. Recognized via Dectin-1, schizophyllan enables precise delivery of oligonucleotide drugs and antigens to antigen-presenting cells, thus holding great potential in the treatment of inflammatory diseases and vaccine development .
Cat. No.: HY-N15723
CAS No.: 99624-66-5
Target:
Cat. No.: HY-W067056
CAS No.: 1754-62-7
Synonyms: Methyl (E)-3-phenylpropenoate
Category:
Simple Phenylpropanols Phenylpropanoids Plants Other Families Extract Disease Research Fields Inflammation/Immunology
Target:
UBS109, as a curcumin analogue, can promote the differentiation and mineralization of osteoblasts. UBS109 shows to regulate bone cell function by activating Smad and inhibiting NF-kB. UBS109 can be used in bone tissue engineering and osteoporosis research .
Cat. No.: HY-W067056S1
CAS No.: 2022152-96-9
Synonyms: Methyl(E)-3-phenylpropenoate-d7
Cat. No.: HY-N15719
CAS No.: 931426-37-8
Category:
Dipsacaceae Extract Triterpenes Terpenoids Dipsacus asper Wall. Plants Pentacyclic Triterpenoids
Target:
Cat. No.: HY-118668
CAS No.: 1117772-52-7
ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.
Cat. No.: HY-103455
CAS No.: 177583-70-9
Target:
Research Areas:
ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.
Cat. No.: HY-W067056R
CAS No.: 1754-62-7
Synonyms: Methyl (E)-3-phenylpropenoate (Standard)
Target:
Cat. No.: HY-W067056S
CAS No.: 61764-82-7
Synonyms: Methyl(E)-3-phenylpropenoate-d5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
