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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
p75NTR
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "p75NTR" in MCE Product Catalog:
7
7 Publications Verification
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LM11A-31 dihydrochloride, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression .
7
7 Publications Verification
Target:
Research Areas:
LM11A-31, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression .
4
4 Cited Publications
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Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75 NTR selectively over TRKA . Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM .
2
2 Cited Publications
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PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75 NTR. PD 90780 inhibits NGF-p75 NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12 nnr5 cells, respectively .
1
1 Cited Publications
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Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
THX-B is a potent and non-peptidic p75 NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders .
Cat. No.: HY-P99297
CAS No.: 2171034-69-6
Synonyms: ZTS-00508841
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NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75 NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75 NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells .
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(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist .
Cat. No.: HY-170409
CAS No.: 1195795-81-3
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
BNN27 is a blood-brain barrier-penetrant, selective NGF receptor (TrkA and p75NTR) activator. BNN27 activates ERK1/2/AKT. BNN27 enhances NGF-induced differentiation/axonal growth and inhibits JNK after NGF withdrawal. BNN27 reduces Amyloid-β plaques, gliosis, and pro-inflammatory cytokines, and rescues synaptic/cholinergic deficits, neurogenesis, and working memory. BNN27 can be used in research on Alzheimer's disease, amyotrophic lateral sclerosis, diabetic retinopathy, inflammatory hyperalgesia, anxiety disorders, and multiple sclerosis .
Cat. No.: HY-W370556
CAS No.: 289475-77-0
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(Rac)-LM11A-31 is a racemate of LM11A-31. LM11A-31 is a non-peptide modulator of p75NTR (neurotrophin receptor p75) and is an orally effective proNGF antagonist .
Cat. No.: HY-P1176
CAS No.: 197230-90-3
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Cat. No.: HY-P1176A
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Cat. No.: HY-111163R
CAS No.: 908563-68-8
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NSC49652 (Standard) is the analytical standard of NSC49652 (HY-111163). This product is intended for research and analytical applications. NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells .
Cat. No.: HY-110166R
CAS No.: 77422-99-2
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PD 90780 (Standard) is the analytical standard of PD 90780 (HY-110166). This product is intended for research and analytical applications. PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
Cat. No.: HY-P992534
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LEVI-04 is a p75NTR-Fc fusion protein. LEVI-04 blocks and clears neurotrophins, binding excess NGF to block NGF activity, and binds NT-3 with high affinity to inhibit NT-3 activity. LEVI-04 inhibits NT-3-mediated TrkC receptor signaling and supplements endogenous p75NTR. LEVI-04 can be used in research on osteoarthritis and knee osteoarthritis .
Cat. No.: HY-P74699
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NGFR; Low Affinity Neurotrophin Receptor p75NTR; Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; TNFRSF16; NGF Receptor; p75NTR; Gp80-LNGFR; CD271; P75 ICD; Tumor Necrosis Factor Receptor Superfamily Member 16; Nerve Growth Factor Receptor (TNF
Species:
Rabbit
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
