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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
positive allosteric modulation
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "positive allosteric modulation" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: AVL-3288; UCI-4083
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CCMI (AVL-3288) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction .
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GNE 5729 is an orally active, blood-brain barrier-penetrant positive allosteric modulator of NMDARs containing the GluN2A subunit. GNE 5729 enhances NMDAR responses through allosteric modulation, exhibits selectivity over other NMDAR subtypes and AMPARs, and can be used for research on depression .
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MIPS521 is a positive allosteric modulator of adenosine A1 receptor (A1AR). MIPS521 also has a lower A1R allosteric affinity (pKB=4.95; KB=11 μM). MIPS521 exhibits pain-relieving effects in vivo through modulation of the increased levels of endogenous adenosine .
Synonyms: NSC 213859
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NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments).
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GS39783 is a positive allosteric modulator (PAM) of GABABR. Positive modulation of the GABABR can be used for the research of Nicotine addiction .
Cat. No.: HY-112603
CAS No.: 1623194-37-5
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AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 demonstrates rat and human inositol monophosphate (IP1) EC50 values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 has the potential for type II diabetes research .
Cat. No.: HY-W634748
CAS No.: 2894-61-3
Synonyms: Bromonordiazepam
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Desalkylgidazepam (Bromonordiazepam) is the major active metabolite of Gidazepam (HY-U00315) and a benzodiazepine agent. Desalkylgidazepam activates GABAA receptors, binds to the benzodiazepine site, enhances GABA-mediated inhibitory neurotransmission, and potentiates GABA-induced chloride ion influx through positive allosteric modulation at α1β2γ2 receptors .
Cat. No.: HY-14451
CAS No.: 1219633-99-4
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PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.
Cat. No.: HY-155484
CAS No.: 1422251-09-9
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SOMCL-668 is a selective and potent sigma-1 receptor allosteric modulator. ?SOMCL-668 shows positive modulation of improvement in social deficits and cognitive impairment induced by the selective sigma-1 agonist PRE084.?SOMCL-668 displays anti-seizure activities and can be used for psychotic illness research .
Cat. No.: HY-112603A
CAS No.: 1623143-67-8
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AP5 sodium is a potent, orall active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 sodium demonstrates rat and human inositol monophosphate (IP1) EC50 values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 sodium has the potential for type II diabetes research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
