118 Results for "

protease processing

" in MedChemExpress (MCE) Product Catalog:
Products (118)

118 Results for "protease processing" in MCE Product Catalog:

881
Z-VAD-FMK
Z-VAD-FMK
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881 Publications Verification
Cat. No.: HY-16658B
CAS No.: 161401-82-7
Synonyms: Z-VAD(OH)-FMK
Target:  

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Research Areas:  

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
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5
Fosamprenavir
Fosamprenavir
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5 Cited Publications
Cat. No.: HY-78726
CAS No.: 226700-79-4
Synonyms: Amprenavir phosphate; GW 433908
Target:  

Drug Intermediate HIV HIV Protease

Research Areas:  

Infection

Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .
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5
Fosamprenavir Calcium Salt
Fosamprenavir Calcium Salt
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5 Cited Publications
Cat. No.: HY-17431
CAS No.: 226700-81-8
Synonyms: GW433908G
Target:  

Drug Intermediate HIV HIV Protease

Research Areas:  

Infection

Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .
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2
Upamostat
Upamostat
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2 Cited Publications
Cat. No.: HY-16511
CAS No.: 590368-25-5
Synonyms: WX-671
Target:  

PAI-1 Ser/Thr Protease

Research Areas:  

Infection Cancer

Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer .
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2
USP7 Protein, Human (sf9)
USP7 Protein, Human (sf9)
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2 Cited Publications
Cat. No.: HY-P74478
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP7; HAUSP; Ubiquitin Specific Peptidase 7; Ubiquitin-Specific-processing protease 7; Ubiquitin Carboxyl-Terminal Hydrolase 7; Deubiquitinating Enzyme 7; Ubiquitin Thioesterase 7; Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated); Herpesvirus-Asso
Species:  
Human
Source:  
Sf9 insect cells
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2
Cathepsin S, human
Cathepsin S, human
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2 Cited Publications
Cat. No.: HY-E70226
CAS No.: 71965-46-3
Synonyms: CTSS
Target:  

Cathepsin Elastase TGF-beta/Smad Protease Activated Receptor (PAR) Sirtuin NF-κB

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer

Human Cathepsin S (CTSS) is a cysteine protease with elastinolytic activity. Human Cathepsin S is inhibited by cysteine protease inhibitors such as E-64 (HY-15282) and cystatin C. Human Cathepsin S cleaves substrates including elastin, TGF-β1, Myelin basic protein (HY-P1821), PAR2, SIRT1, collagen 18A1, FKN, and MHC-II invariant chain fragments, thereby driving processes such as elastic matrix degradation, TGF-β1 signaling, demyelination, PAR2-mediated calcium mobilization, NF-κB activation, hepatic fibrosis, immune homeostasis regulation, and antigen presentation. Human Cathepsin S can be used in the research of cardiovascular diseases, chronic kidney diseases, autoimmune diseases, tumors, Alzheimer's disease, and obesity .
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1
Tumulosic acid
Tumulosic acid
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1 Cited Publications
Cat. No.: HY-N9366
CAS No.: 508-24-7
Category:  

Triterpenes Terpenoids Polyporaceae Extract 500 - Internal Server Error | MedChemExpress

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