Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
protease-degradable
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "protease-degradable" in MCE Product Catalog:
Target:
Research Areas:
SpeB cysteine protease is a potent modifier of immunologically important host and bacterial proteins. SpeB cysteine protease degrades streptolysin O (SLO) in extracellular vesicles .
Cat. No.: HY-P2191
CAS No.: 872717-97-0
Target:
Research Areas:
Cat. No.: HY-161789
Target:
Research Areas:
PROTAC SARS-CoV-2 Mpro degrader-3 is a SARS-CoV-2 Mpro PROTAC degrader with a DC50 of 27 μM in HEK 293T cells. It also acts as an inhibitor of HCoV-229E, HCoV-OC43 and SARS-CoV-2 Mpro, with an IC50 of 0.748 μM and a Kd of 37 μM against SARS-CoV-2 Mpro. PROTAC SARS-CoV-2 Mpro degrader-3 forms a ternary complex with purified SARS-CoV-2 Mpro and VCB E3 ligase to induce intracellular protease degradation. It reduces coronavirus replication and can be used in research on coronavirus infections .
Cat. No.: HY-P12384
CAS No.: 287184-75-2
Target:
Research Areas:
GPQ-W is a synthetic peptide containing a type I collagen-derived protease cleavage site and serves as a protease-degradable crosslinker in PEG-4MAL/RGD synthetic hydrogels. GPQ-W is cleaved by cell-secreted matrix metalloproteinases, enabling cell-mediated matrix degradation and remodeling. GPQ-W, as a PEG-4MAL hydrogel component, supports the in vitro generation of human intestinal and lung organoids from hPSC-derived spheroids, long-term survival of intestinal organoids, normal epithelial cyst polarity, and lumen formation at the rapidly degrading crosslinker threshold level. GPQ-W can be used in research related to intestinal mucosal injury and organoid transplantation .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
