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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
rewarding
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "rewarding" in MCE Product Catalog:
Cat. No.: HY-107121
CAS No.: 676501-25-0
Synonyms: LY 2196044
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Ondelopran (LY 2196044) is a non-selective opioid receptor antagonist. Ondelopran inhibits the release of dopamine in the nucleus accumbens induced by alcohol, reduces the rewarding effect of alcohol consumption, and lowers the craving. Ondelopran can be used for alcohol use disorder (AUD) .
Cat. No.: HY-122979
CAS No.: 55528-07-9
Synonyms: (+)-AY-23,028; d-Butaclamol hydrochloride
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(+)-Butaclamol hydrochloride ((+)-AY-23,028; d-Butaclamol hydrochloride) is a dopamine receptor antagonist that blocks D2 and D1 receptors. (+)-Butaclamol hydrochloride antagonizes Dopamine (HY-B0451)-induced relaxation with a KB of 2 nM-0.17 µM and a Ki of 0.19-0.37 µM. (+)-Butaclamol hydrochloride inhibits adenylyl cyclase-coupled dopamine receptors, displaces striatal D2 radioligand binding, and acts as a non-selective D2 antagonist to retain D1-NLS and D1-D2 hetero-oligomers on the cell surface. (+)-Butaclamol hydrochloride inhibits the rewarding effects and self-administration behavior of dopaminergic agonists. (+)-Butaclamol hydrochloride can be used in research related to schizophrenia .
Cat. No.: HY-167674
CAS No.: 109453-73-8
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Bmapn has rewarding and reinforcing properties, decreases dopamine transporter and increases dopamine receptor D2 gene expression in the striatum .
Cat. No.: HY-189362
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DAT-IN-2 is an atypical dopamine transporter (DAT) inhibitor with blood-brain barrier permeability. DAT-IN-2 binds to human DAT with a Ki of 63.0 nM and stabilizes the transporter in an inward-facing conformation. DAT-IN-2 produces only weak locomotor stimulant effects and does not induce conditioned place preference in mice, indicating no rewarding effects. DAT-IN-2 can be used in research related to psychostimulant use disorder .
Cat. No.: HY-122979A
CAS No.: 56245-67-1
Synonyms: (+)-AY-23,028 free base; d-Butaclamol
Target:
Research Areas:
(+)-Butaclamol ((+)-AY-23,028 free base; d-Butaclamol) is a dopamine receptor antagonist that blocks D2 and D1 receptors. (+)-Butaclamol antagonizes Dopamine (HY-B0451)-induced relaxation with a KB of 2 nM-0.17 µM and a Ki of 0.19-0.37 µM. (+)-Butaclamol inhibits adenylyl cyclase-coupled dopamine receptors, displaces striatal D2 radioligand binding, and acts as a non-selective D2 antagonist to retain D1-NLS and D1-D2 hetero-oligomers on the cell surface. (+)-Butaclamol inhibits the rewarding effects and self-administration behavior of dopaminergic agonists. (+)-Butaclamol can be used in research related to schizophrenia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
