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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
selecive
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "selecive" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
TRPV2-selective blocker 1 is a TRPV2-selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC50 of 6.3 μM against rat TRPV2, and shows no activity against TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral TRPV2. TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2 during immune processes .
2
2 Cited Publications
Cat. No.: HY-P80369
Synonyms: OMP2, VDAC1, YNL055C, N2441, YNL2441C, POR1, Non-selective voltage-gated ion channel 1, Outer mitochondrial membrane protein porin 1, Voltage-dependent anion-selective channel protein 1, VDAC-1
1
1 Cited Publications
Cat. No.: HY-P703329
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TRPM4; LTRPC4; Transient receptor potential cation channel subfamily M member 4; hTRPM4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; Melastatin-4; LTrpC-4; PFHB1B; TRPM4B; EKVP6; FLJ20041
Species:
Human
Source:
HEK293
Cat. No.: HY-P3755
CAS No.: 532441-10-4
Target:
Research Areas:
Cat. No.: HY-149725
Target:
Research Areas:
proMMP-9 selective inhibitor-1 (compound 33) is a highly potent and selective inhibitor of proMMP-9 activation .
Cat. No.: HY-161021
Target:
Research Areas:
AC2 selective-IN-1 (compound 14) is a? potent (IC50=4.45 μM), non-toxic, and selective mAC2 inhibitor .
Cat. No.: HY-153990
CAS No.: 1680228-76-5
Target:
Research Areas:
FKBP51F67V-selective antagonist Ligand2 (example 3-3) is a potent FKBP51 F67V-selective antagonist ligand. FKBP51F67V-selective antagonist Ligand2 reverses the anxiogenic phenotype induced by overexpression of FKBP51 F67V in the amygdala. FKBP51F67V-selective antagonist Ligand2 binds to FKBP51 F67V, but not to wild-type FKBP51 or FKBP52 .
Cat. No.: HY-126123
CAS No.: 457897-92-6
Target:
Research Areas:
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier .
Cat. No.: HY-188092
Target:
Research Areas:
Cortisol-selective aptamer is a nucleic acid that selectively binds to cortisol. Cortisol-selective aptamer undergoes conformational transition upon binding to cortisol, inducing fluorescence quenching of quantum dots. Cortisol-selective aptamer can be integrated into gold nanoparticle colorimetric assays in buffer solutions to distinguish cortisol from other biomarkers of stress and liver dysfunction .
Cat. No.: HY-L158
6,361 compounds
According to reports, most known kinase inhibitors exert their effects through competitive binding in highly conserved ATP pockets. Although genetic techniques such as RNA interference can inactivate specific genes, most kinases are multi domain proteins, each of which has an independent function. Highly selective inhibitors have higher efficiency than non-selective inhibitors, and the selectivity to the target is at least 100 times higher. Therefore, ensuring the validation of targets with the most selective inhibitors is crucial for a more thorough understanding of the pharmacology of the kinase field. The Highly Selective Inhibitors Library contains 6,361 compounds, covering multiple targets and subtypes, such as GPCR protein family, Ion channel, multiple kinases, etc. The Highly Selective Inhibitors Library is an effective tool for screening different phenotypes
Cat. No.: HY-L159
2,214 compounds
Agonistic drugs activate or stimulate their receptors, triggering responses that increase or decrease cell activity. The highly selective activators can act on specific biological or molecular targets, while non-selective activators may interfere with multiple targets or targets simultaneously. The highly selective activators reduce the likelihood of these non-specific effects by targeting specific targets, making research more precise and reliable. The Highly Selective Activators Library contains 2,214 compounds, covering multiple targets and subtypes, such as GPCR protein family, Ion channel, multiple kinases, etc. The Highly Selective Activators Library is an effective tool for screening different phenotypes.
Cat. No.: HY-P71560
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SMUG1; FDG; Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1; Single-Strand Selective Monofunctional Uracil DNA Glycosylase; HMUDG; Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1 Isoform 1; UNG3; Single-Strand-Selective Mon
Species:
Human
Source:
E. coli
Cat. No.: HY-P706341
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Non-selective voltage-gated ion channel VDAC2; VDAC-2; mVDAC2; Outer mitochondrial membrane protein porin 2; Voltage-dependent anion-selective channel protein 6; VDAC-6; mVDAC6; Vdac2; Vdac6
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P706129
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BRSK1; Brain-Selective Kinase 1; BR Serine/Threonine Kinase 1; SAD1 Homolog; KIAA1811; HSAD1; SAD-B; Non-Specific Serine/Threonine Protein Kinase; Brain-Specific Serine/Threonine-Protein Kinase 1; Brain Selective Kinase 1; Synapses Of Amphids Defective Ho
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P70403
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FKBP3; PPIase FKBP3; FKBP Prolyl Isomerase 3; 25 KDa FKBP; FKBP-25; Rotamase; FKBP25; FKBP-3; Peptidyl-Prolyl Cis-Trans Isomerase FKBP3; FK506-Binding Protein 25, T-Cell; Rapamycin-Selective 25 KDa Immunophilin; FK506-Binding Protein 3 (25kD); FK506 Bindi
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
