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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
skin damage
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "skin damage" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-N0260
CAS No.: 110642-44-9
Synonyms: Epimedin-C; Baohuoside-VI
Category:
Flavonols Plant Flavonoids Monophenols Epimedium brevicornu Maxim. Extract Phenols Disease Research Fields Inflammation/Immunology Berberidaceae Extract
Target:
2
2 Cited Publications
Synonyms: Diphosphofructose; Esafosfan; FDP
Category:
Cardiovascular Disease Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Microorganism Endogenous metabolite Disease Research Fields
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2
2 Cited Publications
Synonyms: 3,4-Dihydroxy-benzenepropanoic acid
2
2 Cited Publications
Cat. No.: HY-P5641
CAS No.: 190324-47-1
Research Areas:
1
Target:
Research Areas:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .
1
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Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .
1
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Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity .
1
1 Cited Publications
Cat. No.: HY-A0169A
CAS No.: 79416-27-6
Research Areas:
Methyl aminolevulinate hydrochloride is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate hydrochloride penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate hydrochloride acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate hydrochloride reduces the expression of the proliferation marker Ki-67 and the early skin carcinogenesis marker TP53. Methyl aminolevulinate hydrochloride delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate hydrochloride is applicable to research related to actinic keratosis and basal cell carcinoma .
1
1 Cited Publications
Cat. No.: HY-B0897
CAS No.: 103597-45-1
Target:
Research Areas:
Bisoctrizole is a broad-spectrum UVA/UVB absorber that belongs to the benzotriazole class of compounds. Bisoctrizole absorbs UV light through hydroxyphenyl groups, causing reversible electronic transitions, thereby converting light energy into heat energy, inhibiting UV-induced material or skin damage. Bisoctrizole is highly efficient in capturing UVA (320-400 nm) and some UVB (280-320 nm) radiation. Bisoctrizole delays the photodegradation of materials such as silicones, improving their UV aging resistance or enhancing the photoprotective ability of sunscreen products .
1
1 Cited Publications
Cat. No.: HY-N2466A
CAS No.: 1566590-77-9
Synonyms: MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate
Target:
Research Areas:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) acetate is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I acetate induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I acetate impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I acetate can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .
1
1 Cited Publications
MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction .
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Cat. No.: HY-N6821
CAS No.: 129499-78-1
Target:
Research Areas:
2-O-α-D-Glucopyranosyl-L-ascorbic Acid is an orally active glucoside derivative of ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be hydrolyzed by α-glucosidase to release ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid inhibits melanin synthesis, prevents UV-induced cell damage, and promotes collagen synthesis in skin fibroblasts. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid also induces oxidative stress to inhibit tumor growth. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be used in research related to tumors, inflammation, and other conditions .
Cat. No.: HY-P10533
CAS No.: 845727-64-2
Target:
Research Areas:
Synonyms: LUT014
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Omzirafenib (LUT014) is a topical inhibitor targeting BRAF that cannot pass through the blood-brain barrier. Omzirafenib inhibits BRAF kinase and abnormally activates the MAPK/ERK signaling pathway, promoting the proliferation of epidermal keratinocytes, repairing skin barrier damage caused by radiation damage, and alleviating inflammatory responses. Omzirafenib is independent of RAS signaling and accelerates the repair and regeneration of damaged skin cells. Omzirafenib can be used to study radiation dermatitis, especially skin damage caused by breast cancer radiotherapy .
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Linoleic acid is a critical component of polyunsaturated fatty acids. Linoleic acid reduces GSH-PX and T-SOD activities. Linoleic acid functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid can cause acute oxidative damage to red blood cells, ultimately leading to partial acute anemia. Linoleic acid can be used in the research of skin diseases associated with linoleic acid deficiency .
Cat. No.: HY-N5048
CAS No.: 122965-41-7
Synonyms: 6'-O-Galloyl paeoniflorin
Cat. No.: HY-N1407
CAS No.: 162857-78-5
Category:
Plant Polygala tenuifolia Willd. Extract Xanthones Polygalaceae Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-N2232
CAS No.: 66648-44-0
Synonyms: N-trans-Feruloyloctopamine
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
