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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
snRNA
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "snRNA" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .
Cat. No.: HY-161402
Target:
Research Areas:
METTL16-IN-1 is a potent METTL16 inhibitor with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. Mettl16-in-1 inhibits the binding interaction of U6 snRNA deletion and METTL16 MTD with an IC50 value of 2.5 μM. METTL16-IN-1 has antitumor activity .
Cat. No.: HY-179117
CAS No.: 1340819-53-5
Target:
Research Areas:
RNA splicing modulator 5 (compound 22) is a small molecule probe that can specifically target the K-turn region of U4/U6 snRNA. RNA splicing modulator 5 can stabilize RNA structure in vitro and inhibit its binding to Snu13 protein (IC50 = 3.2 μM) .
Cat. No.: HY-133895
CAS No.: 1449592-94-2
Target:
Research Areas:
SMN-C5 is an inducer of SMN2 exon 7 inclusion. SMN-C5 binds to the SMN2 exon 7 5′-splice site/U1 snRNA helix (Kd = 28 μM) and positively allosterically modulates SMN2 splicing correction. SMN-C5 binds to SMN2 exon 7 ESE2 and partially displaces hnRNP G, enhances the affinity of U1 snRNP for the weak splice site, binds to a bulged adenine in the major groove and forms hydrogen bonds, while not affecting the interaction of Tra2-β1 with ESE2 RNA. SMN-C5 can be used for research on spinal muscular atrophy .
Cat. No.: HY-153269
CAS No.: 2248691-80-5
Target:
Research Areas:
9-Methyl-SMN-C5 is a SMN2 pre-mRNA splicing modifier that corrects exon 7 splicing. 9-Methyl-SMN-C5 binds to ESE2 and the 5'-splice site of exon 7, and stabilizes the RNP complex. 9-Methyl-SMN-C5 induces chemical shift perturbations at the 5'-splice site of the exon 7-U1 snRNA duplex. 9-Methyl-SMN-C5 partially blocks the binding of hnRNP G to ESE2. 9-Methyl-SMN-C5 can be used for research on spinal muscular atrophy (SMA) .
Cat. No.: HY-P70198
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LSM1; LSM1 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae); LSM1 Homolog, MRNA Degradation Associated; LSM1-Like Protein U6 Small Nuclear RNA Associated Isoform 3; CASM; LSM1-Like Protein U6 Small Nuclear RNA Associated; U6 snRNA-Associated Sm-Li
Species:
Human
Source:
E. coli
Cat. No.: HY-P70944
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LSM4; GRP; LSM4 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated; LSM4 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae); U6 snRNA-Associated Sm-Like Protein LSm4; LSM4 U6 Small Nuclear RNA And MRNA Degradation Associated; YER112W; LSM
Species:
Human
Source:
E. coli
Cat. No.: HY-P75915
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LSM3; USS2; LSM3 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated; LSM3 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae); U6 snRNA-Associated Sm-Like Protein LSm3; LSM3 U6 Small Nuclear RNA And MRNA Degradation Associated; YLR438C; LS
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
