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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
thioesterases
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "thioesterases" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: GNF-Pf-1127
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ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2 .
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8 Cited Publications
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ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM .
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2 Cited Publications
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Cat. No.: HY-P10486
CAS No.: 200010-31-7
Cat. No.: HY-145519
CAS No.: 229644-17-1
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Mu-6S-Palm-β-Glc is a fluorogenic substrate for palmitoyl-protein thioesterase (PPT). Mu-6S-Palm-β-Glc can be used for the research of neuronal ceroid lipofuscin disease in infants .
Cat. No.: HY-18522
CAS No.: 1312782-34-5
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AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .
Cat. No.: HY-P4909
CAS No.: 200010-29-3
Synonyms: AIP-I
Autoinducing Peptide I (AIP-I) is a competitive AgrC antagonist and AgrC I activator. By blocking AIP-AgrC interaction and agr quorum sensing signaling, it inhibits MRSA agr-I and agr-III and protects the mouse skin barrier. Autoinducing Peptide I can be used in research on Staphylococcus aureus infection .
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S-Acetylglutathione is a glutathione derivative and intracellular glutathione supplement that bypasses glutathione synthetase deficiency through intracellular thioesterase conversion, exhibits higher blood stability than glutathione, and selectively induces apoptosis in lymphoma and malignant cells by inducing oxidative stress (apoptosis). S-Acetylglutathione can be used in research on glutathione synthetase deficiency, herpes simplex virus type 1 infection, murine AIDS, lymphoma, and malignant tumors .
Cat. No.: HY-E70277
CAS No.: 71425-89-3
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Hexadecyl-CoA is a non-hydrolyzable thioether analog of Palmitoyl-CoA. Hexadecyl-CoA competitively inhibits the acyl-CoA thioesterase activity of HNF-4α with a Ki of 0.3 μM, and inhibits DGAT2 activity with an IC50 of approximately 2 μM. Hexadecyl-CoA also inhibits ATGL activity and serves as a reference inhibitor for DGAT2 LC/MS enzyme activity assays. Hexadecyl-CoA can be used in studies related to lipid metabolism, triglyceride synthesis and lipolysis .
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ABC44 is a potent serine hydrolase inhibitor, with IC50 values of 0.1 μM (HEK293T in situ), 6.5 μM (HEK293T in vitro), and 1.26 μM (cell-free enzymatic assay) against palmitoyl-protein thioesterase 1 (PPT1). ABC44 can be used for research on late infantile neuronal ceroid lipofuscinosis and cancer .
Cat. No.: HY-W004782
CAS No.: 23806-24-8
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3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a Kd of 19.6 µM and an IC50 of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research .
Cat. No.: HY-118621
CAS No.: 126062-19-9
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii . JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase .
Cat. No.: HY-118147
CAS No.: 1808260-45-8
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ML356 (Compound 16) is an inhibitor for fatty acid synthase (FAS), that inhibits the thioesterase domain of FAS (FAS TE) with an IC50 of 0.334 μM, and blocks the de novo palmitate synthesis in PC-3 cell with an IC50 of 20 μM. ML356 exhibits good membrane permeability, and good stability in human and mouse plasma .
Cat. No.: HY-P2424
CAS No.: 144396-38-3
Synonyms: CCK-J
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Cat. No.: HY-CE00345
CAS No.: 27718-41-8
Synonyms: Coenzyme A,S-(4-hydroxybenzoate); 4-Hydroxybenzoyl-CoA; 4-Hydroxybenzoyl-coenzyme A
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(4-Hydroxybenzoyl)-CoA (Coenzyme A,S-(4-hydroxybenzoate)) is the S-(4-hydroxybenzoyl) derivative of coenzyme A. 4-Hydroxybenzoyl-CoA binds to the thioesterase active site and is hydrolyzed to CoA and 4-HBA. 4-Hydroxybenzoyl-CoA is the natural substrate of 4-Hydroxybenzoyl-CoA thioesterase and is also the dehalogenase product bound at its active site in the crystal structure .
Cat. No.: HY-151598
CAS No.: 3031462-75-3
Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.30 μM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB .
Cat. No.: HY-151599
CAS No.: 3031462-62-8
Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB .
Cat. No.: HY-116846
CAS No.: 42609-73-4
Methyldymron is a herbicide that act on acyl-ACP thioesterase (FAT) .
Cat. No.: HY-E71068
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(3S)-Malyl-CoA thioesterase (EC 3.1.2.30) is stimulated by Mg2+ or Mn2+. (3S)-Malyl-CoA thioesterase (EC 3.1.2.30) has no activity with (2R,3S)-2-methylmalyl-CoA or other CoA esters.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
