Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
thiourea
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "thiourea" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: NSC55712; TPU-260 Dihydrochloride
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
2
2 Cited Publications
Research Areas:
Diafenthiuron is a thiourea compound commonly used a broad-spectrum insecticide and acaricide. Diafenthiuron disturbs the insect respiratory system by inhibiting the oxidative phosphorylation and mitochondrial ATP synthesis .
1
1 Cited Publications
Cat. No.: HY-169703
CAS No.: 1251839-15-2
Target:
Research Areas:
SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis .
Target:
Research Areas:
Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL .
Cat. No.: HY-P5290
CAS No.: 2213408-17-2
Research Areas:
Cat. No.: HY-W015915
CAS No.: 1758-73-2
Synonyms: thiourea dioxide
Cat. No.: HY-120781
CAS No.: 1454662-54-4
Target:
Research Areas:
Fluorescein-thiourea-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Fluorescein-thiourea-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-130160
CAS No.: 1146195-72-3
Target:
Research Areas:
Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Fluorescein-thiourea-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-D1896
CAS No.: 187404-67-7
Cat. No.: HY-P5292A
CAS No.: 2375849-11-7
Research Areas:
Cat. No.: HY-P5292
CAS No.: 2192215-74-8
Research Areas:
Cat. No.: HY-136952
CAS No.: 1822331-55-4
Research Areas:
p-SCN-Bn-HOPO is a bifunctional chelator that forms stable octadentate complexes with Zr (IV) and 89Zr 4+ via four 1,2-hydroxypyridone groups. p-SCN-Bn-HOPO conjugates with antibodies through the formation of thiourea bonds with lysine residues, and enables efficient 89Zr radiolabeling under mild conditions. p-SCN-Bn-HOPO inhibits bone uptake of free radiometals, stabilizes radiometal-antibody conjugates, and achieves PET imaging with low background and enhanced tumor-to-organ contrast. p-SCN-Bn-HOPO can be used in breast cancer-related research .
Cat. No.: HY-159183
CAS No.: 1807847-98-8
Research Areas:
THP-NCS is a bifunctional chelator bearing an isothiocyanate group, enabling radiolabeling. THP-NCS can conjugate antibody fragments for gallium isotope radiolabeling in ImmunoPET imaging. THP-NCS can conjugate biomolecules, including cyclic RGD peptides. THP-NCS can conjugate PEGylated liposomes or bone-targeting aminobisphosphonates via thiourea bonds for metal chelation pretargeting .
Cat. No.: HY-W540036
CAS No.: 1544-68-9
Target:
Research Areas:
4-Fluorophenyl isothiocyanate is an aryl isothiocyanate reagent and synthetic building block. 4-Fluorophenyl isothiocyanate is used to prepare quinazolinone derivatives, (S)-naproxen-derived 1,2,4-triazoles, isoniazid-derived thiosemicarbazones, isatin-β-thiosemicarbazones, thioureas, thiazolidinones, thiazolines, triazoles, and thiadiazoles. 4-Fluorophenyl isothiocyanate reacts with hydrazine to form a dimer of two thiocyanate groups linked by hydrazine, and the formation of this dimer can be avoided by reacting tert-butyl carbazate with the isothiocyanate .
Cat. No.: HY-140943
CAS No.: 2353409-59-1
Target:
Research Areas:
Biotin-PEG7-thiourea is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-13769
CAS No.: 769856-81-7
Synonyms: TPU260
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 (TPU260), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
Cat. No.: HY-W743390
CAS No.: 2512193-20-1
Synonyms: 4-Methylimidazolidine-2-thione-d6
Research Areas:
Propylene thiourea-d6 (4-Methylimidazolidine-2-thione-d6) is deuterium labeled Propylene thiourea. Propylene thiourea is one of the main degradation products of Propineb (HY-119630) in animals, plants and during processing .
Cat. No.: HY-133061
CAS No.: 2055014-69-0
Target:
Research Areas:
Fluorescein-thiourea-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-114747
CAS No.: 25444-85-3
Synonyms: 1-(1-Adamantyl)-3-propyl-2-thiourea
Target:
Research Areas:
1-(Adamantan-1-yl)-3-propylthiourea (1-(1-Adamantyl)-3-propyl-2-thiourea) is a member of the virus-inhibitory N--thiourea class .
Cat. No.: HY-W015915R
CAS No.: 1758-73-2
Synonyms: thiourea dioxide (Standard)
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
