69 Results for "

virulence factor

" in MedChemExpress (MCE) Product Catalog:
Products (69)

69 Results for "virulence factor" in MCE Product Catalog:

16
Clindamycin
Clindamycin
0 Images
16 Publications Verification
Cat. No.: HY-B1455
CAS No.: 18323-44-9
Target:  

Bacterial Antibiotic Parasite

Research Areas:  

Infection Cancer

Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .
loading...
    loading...
View All Sizes
16
Clindamycin hydrochloride monohydrate
Clindamycin hydrochloride monohydrate
0 Images
16 Publications Verification
Cat. No.: HY-N7118
CAS No.: 58207-19-5
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Cancer

Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla) .
loading...
    loading...
View All Sizes
4
Lipopolysaccharides, from P. gingivalis
Lipopolysaccharides, from P. gingivalis
0 Images
4 Cited Publications
Cat. No.: HY-D1056D
Synonyms: LPS, from Porphyromonas gingivalis
Lipopolysaccharides, from P. gingivalis (LPS, from Porphyromonas gingivalis) are endotoxins and TLR4 activators extracted from Porphyromonas gingivalis (P. gingivalis) and are classified as S (smooth) type LPS. Lipopolysaccharides, from P. gingivalis possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from P. gingivalis activate TLR-4 in immune cells and are important virulence factors in the mechanism of periodontal disease. Lipopolysaccharides, from P. gingivalis can be used in research related to periodontitis .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
loading...
    loading...
View All Sizes
1
Neuraminidase, Microorganism
Neuraminidase, Microorganism
0 Images
1 Cited Publications
Cat. No.: HY-P2988
CAS No.: 9001-67-6
Synonyms: Exo-α-sialidase
Target:  

Sialyltransferase

Research Areas:  

Infection

Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .
loading...
    loading...
View All Sizes
N-(3-Oxohexanoyl)-L-homoserine lactone
N-(3-Oxohexanoyl)-L-homoserine lactone
0 Images
Cat. No.: HY-W008806
CAS No.: 143537-62-6
Synonyms: OHHL; N-(3-Oxohexanoyl)homoserine lactone
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

N-(3-Oxohexanoyl)-L-homoserine lactone (OHHL; N-(3-Oxohexanoyl)homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a Kd of 1.8 μM. N-(3-Oxohexanoyl)-L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N-(3-Oxohexanoyl)-L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N-(3-Oxohexanoyl)-L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica .
loading...
    loading...
View All Sizes
Suvratoxumab
Suvratoxumab
0 Images
Cat. No.: HY-P99583
CAS No.: 1629620-18-3
Synonyms: MEDI4893

Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .
loading...
    loading...
View All Sizes
β-N-Acetylhexosaminidase, Streptococcus pneumoniae
β-N-Acetylhexosaminidase, Streptococcus pneumoniae
0 Images
Cat. No.: HY-P2866
CAS No.: 9012-33-3
Target:  

Endogenous Metabolite Bacterial

Research Areas:  

Infection Inflammation/Immunology

β-N-Acetylhexosaminidase, Streptococcus pneumoniae is a cell surface virulence factor of Streptococcus pneumoniae, which contains two synergistically acting GH20 domains (with higher activity in GH20-2). β-N-Acetylhexosaminidase, Streptococcus pneumoniae specifically recognizes and hydrolyzes substrates with β(1,2) glycosidic bonds via Trp-443 and Tyr-482 residues. β-N-Acetylhexosaminidase, Streptococcus pneumoniae catalyzes the hydrolysis of β(1,2)-linked N-acetylglucosamine groups and related disaccharides, and promotes persistent colonization of bacteria in the airway by modifying host defense molecules and releasing monosaccharides for bacterial growth. β-N-Acetylhexosaminidase, Streptococcus pneumoniae can be used in studies related to Streptococcus pneumoniae infection, acute pneumonia, otitis media and meningitis .
loading...
    loading...
View All Sizes
D-Histidine
D-Histidine
0 Images
Cat. No.: HY-W012572
CAS No.: 351-50-8
Target:  

Mitochondrial Metabolism Bacterial

Research Areas:  

Infection Metabolic Disease

D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) .
loading...
    loading...
View All Sizes
LasR antagonist-2
LasR antagonist-2
0 Images
Cat. No.: HY-W104758
CAS No.: 15015-57-3
Target:  

Elastase Bacterial

Research Areas:  

Infection

LasR antagonist-2 is a LasR competitive antagonist and quorum sensing inhibitor, with a Kd value of 7.04 μM against LasR of Pseudomonas aeruginosa. LasR antagonist-2 reduces the production of virulence factors including elastase (elastase), pyocyanin (pyocyanin) and rhamnolipid (rhamnolipid). LasR antagonist-2 inhibits bacterial (bacterial) swarming and swimming motility, and moderately suppresses biofilm formation. LasR antagonist-2 inhibits Pseudomonas aeruginosa infection in the greater wax moth larva model. Elastase-IN-3 can be used in studies related to Pseudomonas aeruginosa infection .
loading...
    loading...
View All Sizes
Cholera autoinducer 1
Cholera autoinducer 1
0 Images
Cat. No.: HY-145376
CAS No.: 1004296-82-5
Purity:  99.32%
Synonyms: CAI-1
Target:  

Bacterial

Research Areas:  

Infection

Cholera autoinducer 1 (CAI-1) is the major autoinducer in quorum sensing of V. cholerae. Cholera autoinducer 1 accumulates extracellularly as cell density increases, can be detected by V. cholerae, and signals through CqsS to regulate gene expression and inhibit biofilm formation and virulence factor production. Cholera autoinducer 1 can be used for cholera research .
loading...
    loading...
View All Sizes
DABCYL-LPETG-EDANS
DABCYL-LPETG-EDANS
0 Images
Cat. No.: HY-P5481
CAS No.: 1807943-24-3
Target:  

Inhibitory Antibodies

Research Areas:  

Others

DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)
loading...
    loading...
View All Sizes
2-tert-Butyl-1,4-benzoquinone
2-tert-Butyl-1,4-benzoquinone
0 Images
Cat. No.: HY-W017187
CAS No.: 3602-55-9
Target:  

Bacterial Drug Metabolite Keap1-Nrf2 Heme Oxygenase (HO)

Research Areas:  

Infection

2-tert-Butyl-1,4-benzoquinone is a food additive oxidant, an electrophilic metabolite of Butylated hydroxyanisole (HY-B1066), and an antibacterial agent. 2-tert-Butyl-1,4-benzoquinone reduces virulence factors, activates Nrf2, and induces S-arylation of its negative regulator Keap1. 2-tert-Butyl-1,4-benzoquinone induces HO-1. 2-tert-Butyl-1,4-benzoquinone exhibits quorum sensing inhibitory activity against Chromobacterium violaceum .
loading...
    loading...
View All Sizes
Feruloyl esterase
Feruloyl esterase
0 Images
Cat. No.: HY-E70115
CAS No.: 134712-49-5
Target:  

Fungal Bacterial

Research Areas:  

Infection

Feruloyl esterase is a subclass of carboxylesterases that hydrolyzes the ester linkages between hydroxycinnamic acids and arabinoxylan/pectin polysaccharides in plant cell walls. Feruloyl esterase can hydrolyze ethyl ferulate to release ferulic acid, disrupt plant cell wall structure, promote fiber swelling, and facilitate cellulase hydrolysis. Feruloyl esterase synergizes with xylanase by removing ferulic acid side chains, thereby promoting efficient hydrolysis of xylan into monomers. Feruloyl esterase acts as a virulence factor for Verticillium dahliae VdFAE and Magnaporthe oryzae Fae1, facilitating host infection and colonization. Feruloyl esterase promotes the degradation of cotton GhDFR through binding to its NADPH domain, thereby inhibiting flavonoid-mediated innate immunity and inducing cell death in Nicotiana benthamiana. Feruloyl esterase can be used in studies related to verticillium wilt and rice blast .
loading...
    loading...
View All Sizes
Pneumolysin-IN-1
Pneumolysin-IN-1
0 Images
Cat. No.: HY-163542
CAS No.: 330842-49-4
Target:  

Bacterial

Research Areas:  

Inflammation/Immunology

Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM). Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae .
loading...
    loading...
View All Sizes
Tropone
Tropone
0 Images
Cat. No.: HY-W035904
CAS No.: 539-80-0
Synonyms: Cycloheptatrienone
Category:  

Ketones, Aldehydes, Acids Other Diseases Plants Other Families Extract Disease Research Fields

Target:  

Drug Intermediate Bacterial

Tropone (Cycloheptatrienone) is a non-benzenoid aromatic natural product that acts as a membrane reverse transporter and metal chelator. Tropone disrupts the proton motive force by affecting the transmembrane proton gradient and functions as a quorum sensing signal through LuxR-type transcriptional regulators. Tropone exhibits broad-spectrum antibiotic, anticancer, algicidal, and probiotic activities. As a virulence factor toxic to rice seedlings, Tropone promotes biofilm formation in Burkholderia plantarii and induces neurotoxicity involving mitochondrial and cytoskeletal damage, increased Ca 2+ influx, and oxidative stress. Tropone is used in the study of bacterial infections .
loading...
    loading...
View All Sizes
cis-11-Methyl-2-dodecenoic acid
cis-11-Methyl-2-dodecenoic acid
0 Images
Cat. No.: HY-134215
CAS No.: 677354-23-3
Target:  

Bacterial Fungal

Research Areas:  

Infection

cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems. DSF is involved in the regulation of virulence and biofilm formation of a variety of bacterial pathogens .
loading...
    loading...
View All Sizes
4-(tert-Butyl)-benzhydroxamic Acid
4-(tert-Butyl)-benzhydroxamic Acid
0 Images
Cat. No.: HY-114818
CAS No.: 62034-73-5
Purity:  99.49%
Target:  

Bacterial

Research Areas:  

Infection

4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM .
loading...
    loading...
View All Sizes
Albicidin
Albicidin
0 Images
Cat. No.: HY-108988
CAS No.: 1622253-00-2
Target:  

Antibiotic Bacterial Topoisomerase DNA/RNA Synthesis

Research Areas:  

Infection

Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight .
loading...
    loading...
View All Sizes
Clindamycin-13C,d3
Clindamycin-13C,d3
0 Images
Cat. No.: HY-B1455S1
CAS No.: 2140264-63-5
Clindamycin- 13C,d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .
loading...
    loading...
View All Sizes
Thymidine-5'-diphosphate-L-rhamnose
Thymidine-5'-diphosphate-L-rhamnose
0 Images
Cat. No.: HY-N11102
CAS No.: 2147-59-3
Synonyms: dTDP-L-Rhamnose
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.