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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
ASM
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "ASM" in MCE Product Catalog:
10
Research Areas:
Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .
7
7 Cited Publications
Cat. No.: HY-P80484
Synonyms: alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-Smooth Muscle Actin; α Smooth Muscle Actin;
6
Target:
Research Areas:
Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity .
1
1 Cited Publications
Cat. No.: HY-P76134
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SMPD1; Niemann-Pick Type A/B; Sphingomyelin Phosphodiesterase 1; Sphingomyelin Phosphodiesterase 1 Isoform 7; Acid Sphingomyelinase; SMPD1 Protein; ASM; ASMASE; Sphingomyelin Phosphodiesterase; ASMase; Sphingomyelin Phosphodiesterase 1, Acid Lysosomal; NP
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-48917
CAS No.: 15049-93-1
Synonyms: C10 Bisphosphonate
Target:
Research Areas:
ARC39 (C10 Bisphosphonate) is a selective acid sphingomyelinase (acid sphingomyelinase, ASM) inhibitor (IC50 = 20 nM) that binds the catalytic zinc center and blocks sphingomyelin hydrolysis. ARC39 shows higher selectivity for acid sphingomyelinase than for neutral sphingomyelinase and Ser/Thr protein phosphatases, while not affecting acid ceramidase, neutral ceramidase, sphingosine kinase 1, and sphingosine kinase 2. ARC39 reduces pulmonary edema, platelet- and ASM-promoted melanoma adhesion, and necroptosis-associated ceramide accumulation, and restores necroptotic viability. ARC39 can be used in research on platelet-activating factor (PAF)-induced pulmonary edema, melanoma, major depressive disorder, and colorectal cancer .
Target:
Research Areas:
ASM-IN-1 is a potent and orally active acid sphingomyelinase (ASM) inhibitor with an IC50 value of 1.5 µM. ASM-IN-1 reduces lipid plaques in the aortic arch and aorta and reduces plasma ceramide concentration and Ox-LDL levels. ASM-IN-1 shows antiatherosclerotic and anti-inflammatory activity .
Cat. No.: HY-171962A
CAS No.: 2376132-24-8
Target:
Research Areas:
KARI 201 hydrochloride is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 hydrochloride is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 hydrochloride competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 hydrochloride activates GHSR-1a and induces calcium influx. KARI 201 hydrochloride ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 hydrochloride can be used in Alzheimer's disease-related research .
Synonyms: ASM
Research Areas:
Acibenzolar-S-methyl (ASM) is a synthetic analog of Salicylic acid (HY-B0167) and a plant activator. Acibenzolar‑S‑methyl induces increased activities of defense-related enzymes such as peroxidase and chitinase, activates stomatal defense responses and PR defense gene expression, induces the production of ROS, triggers local and systemic acquired resistance, and inhibits the proliferation of bacterial and fungal pathogens in plants. Acibenzolar‑S‑methyl can be used in studies related to plant infection .
Research Areas:
Ethacrynic acid (Standard) is the analytical standard of Ethacrynic acid. This product is intended for research and analytical applications. Ethacrynic acid (Etacrynic acid) is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .
Cat. No.: HY-162613
CAS No.: 2305789-66-4
Target:
Research Areas:
ASM-IN-2 (Compound 46) is a potent ASM inhibitor with an IC50 value of 0.87 μM, displaying good drug-like properties. ASM-IN-2 involves in multiple antidepressant mechanisms of actionin, which are associated with a decline of ceramide. It demostrates remarkable antidepressant effects in the CUMS-induced mouse, which is promising for research in the field of antidepressant drugs .
Cat. No.: HY-116541R
CAS No.: 135158-54-2
Synonyms: ASM (Standard)
Research Areas:
Acibenzolar-S-methyl (Standard) (ASM (Standard)) is the analytical standard of Acibenzolar-S-methyl (HY-116541). This product is intended for research and analytical applications. Acibenzolar-S-methyl (ASM) is a synthetic analog of Salicylic acid (HY-B0167) and a plant activator. Acibenzolar‑S‑methyl induces increased activities of defense-related enzymes such as peroxidase and chitinase, activates stomatal defense responses and PR defense gene expression, induces the production of ROS, triggers local and systemic acquired resistance, and inhibits the proliferation of bacterial and fungal pathogens in plants. Acibenzolar‑S‑methyl can be used in studies related to plant infection .
Cat. No.: HY-171962
CAS No.: 2376132-22-6
Target:
Research Areas:
KARI 201 is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 activates GHSR-1a and induces calcium influx. KARI 201 ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 can be used in Alzheimer's disease-related research .
Cat. No.: HY-RS17994
Target:
Research Areas:
Smpd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smpd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Cat. No.: HY-171033
CAS No.: 2342576-75-2
Target:
Research Areas:
ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats .
Cat. No.: HY-13723A
CAS No.: 1000802-56-1
Synonyms: SDZ-ASM 981 hydrate
Target:
Research Areas:
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus .
Cat. No.: HY-13723R
CAS No.: 137071-32-0
Synonyms: SDZ-ASM 981 (Standard)
Target:
Research Areas:
Pimecrolimus (Standard) is the analytical standard of Pimecrolimus. This product is intended for research and analytical applications. Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity .
Cat. No.: HY-RS13447
Target:
Research Areas:
SMPD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMPD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Research Areas:
Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .
Cat. No.: HY-108538
CAS No.: 1330052-59-9
Research Areas:
Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
