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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
AT-rich
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "AT-rich" in MCE Product Catalog:
25
25 Publications Verification
Synonyms: bisBenzimide H 33258; H 33258
3
Target:
Research Areas:
PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively .
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1 Cited Publications
Cat. No.: HY-N6800A
CAS No.: 18133-22-7
Target:
Research Areas:
Seco-DUBA hydrochloride is a DNA-targeting cytotoxic agent. Seco-DUBA hydrochloride binds to the minor groove of A-T-rich DNA regions, alkylates the adenine N3 residue, and undergoes spontaneous spirocyclization to generate active DUBA (HY-160969). Seco-DUBA hydrochloride exerts cytotoxic activity against human cancer cells. The reduced hydrophobicity of Seco-DUBA hydrochloride supports the development of antibody-drug conjugates .
Cat. No.: HY-U00035
CAS No.: 1000277-08-6
Target:
Research Areas:
MGB-BP-3 is an orally aective Gram-positive bactericide and DNA-binding agent. MGB-BP-3 blocks transcription initiation by binding to AT-rich bacterial DNA regions, and interferes with the functions of DNA gyrase and topoisomerase IV, but does not stabilize cleavage complexes or induce the SOS response. MGB-BP-3 induces energy depletion in *Staphylococcus aureus* and inhibits spore formation in *Clostridioides difficile*, exhibiting intrinsic resistance resilience. MGB-BP-3 can be used in the research of *Clostridioides difficile*-associated diseases .
Cat. No.: HY-12455
CAS No.: 118292-34-5
Research Areas:
Duocarmycin A is an antitumor antibiotic and DNA alkylating agent with broad-spectrum antibacterial activity, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). Duocarmycin A selectively binds to the AT-rich minor groove of DNA, forms covalent adducts by alkylating the adenine N3 residue, thereby disrupting DNA structure and inhibiting its replication and transcription. Duocarmycin A induces apoptosis, sub-G1 phase accumulation and chromatin condensation, reduces the levels of pro-caspase-3/9, and induces p53-independent p21 expression. Duocarmycin A is widely used in the research of various malignancies, including leukemia, sarcoma, glioblastoma, as well as multiple solid tumor models such as lung cancer, breast cancer, and colorectal cancer .
Cat. No.: HY-D1660
CAS No.: 57576-49-5
Synonyms: NSC 219743
Acridine homodimer (NSC 219743), acridine dimer, is a fluorescence dye. Acridine homodimer emits a blue-green fluorescence when bound to DNA. Acridine homodimer has extremely high affinity for AT-rich regions of nucleic acids, can be used for chromosome banding .
Category:
Cat. No.: HY-P81409A
Synonyms: DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)
Cat. No.: HY-147549
CAS No.: 2492436-35-6
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .
Cat. No.: HY-147550
CAS No.: 2492436-38-9
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .
Cat. No.: HY-U00035R
CAS No.: 1000277-08-6
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Research Areas:
MGB-BP-3 (Standard) is the analytical standard of MGB-BP-3 (HY-U00035). This product is intended for research and analytical applications. MGB-BP-3 is an orally aective Gram-positive bactericide and DNA-binding agent. MGB-BP-3 blocks transcription initiation by binding to AT-rich bacterial DNA regions, and interferes with the functions of DNA gyrase and topoisomerase IV, but does not stabilize cleavage complexes or induce the SOS response. MGB-BP-3 induces energy depletion in *Staphylococcus aureus* and inhibits spore formation in *Clostridioides difficile*, exhibiting intrinsic resistance resilience. MGB-BP-3 can be used in the research of *Clostridioides difficile*-associated diseases .
Cat. No.: HY-P87888
Synonyms: BAF250, BAF250A, C1orf4, OSA1, SMARCF1, ARID1A, AT-rich interactive domain-containing protein 1A, ARID domain-containing protein 1A, B120, BRG1-associATed factor 250, BRG1-associATed factor 250a, Osa homolog 1, SWI-like protein, SWI/SNF complex protein p270, hELD, hOSA1
Cat. No.: HY-P702875
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: KDM5A; Histone Demethylase JARID1A; Prev. RBBP2; RBP2; Prev. JARID1A; Jumonji, AT rich Interactive Domain 1A (RBBP2-Like); Lysine-Specific Demethylase 5A; Jumonji, AT rich Interactive Domain 1A (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703589
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KDM5A; Histone Demethylase JARID1A; Prev. RBBP2; RBP2; Prev. JARID1A; Jumonji, AT rich Interactive Domain 1A (RBBP2-Like); Lysine-Specific Demethylase 5A; Jumonji, AT rich Interactive Domain 1A (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5A; Jumonji, AT rich Interactive Domain 1A; Jumonji/ARID Domain-Containing Protein 1A; Retinoblastoma Binding Protein 2; Lysine (K)-Specific Demethylase 5A; NEDEHC; Retinoblastoma-Binding Protein 2; Lysine Demethylase 5A; RBBP-2
Species:
Human
Source:
E. coli
Cat. No.: HY-185488
CAS No.: 2592397-70-9
Research Areas:
seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
