83 Results for "

CaCo-2

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "CaCo-2" in MCE Product Catalog:

10
Lipofermata
Lipofermata
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10 Publications Verification
Cat. No.: HY-116788
CAS No.: 297180-15-5
Purity:  99.75%
Target:  

Bacterial

Research Areas:  

Infection

Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. Lipofermata, an analog of spiro-indoline-thadiazole, shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM [2] .
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5
Vildagliptin
Vildagliptin
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5 Cited Publications
Cat. No.: HY-14291
CAS No.: 274901-16-5
Purity:  99.93%
Synonyms: LAF237; NVP-LAF 237
Target:  

Dipeptidyl Peptidase Ferroptosis Apoptosis

Research Areas:  

Metabolic Disease Cancer

Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
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3
Zotiraciclib
Zotiraciclib
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3 Cited Publications
Cat. No.: HY-15163
CAS No.: 1204918-72-8
Synonyms: TG02; SB1317
Target:  

JAK CDK FLT3

Research Areas:  

Cancer

Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma [2].
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2
D-Ala-Lys-AMCA hydrochloride
D-Ala-Lys-AMCA hydrochloride
0 Images
2 Cited Publications
Cat. No.: HY-111956B
CAS No.: 2703746-41-0
Purity:  98.77%
Target:  

Fluorescent Dye

Research Areas:  

Cancer

D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm) [2].
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1
5β-Cholanic acid
5β-Cholanic acid
0 Images
1 Cited Publications
Cat. No.: HY-W127512
CAS No.: 546-18-9
Target:  

Drug Intermediate

Research Areas:  

Others

5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems [2].
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1
Leucomalachite green
Leucomalachite green
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1 Cited Publications
Cat. No.: HY-D0300
CAS No.: 129-73-7
Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant [2].
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1
1-Monopalmitolein
1-Monopalmitolein
0 Images
1 Cited Publications
Cat. No.: HY-133948
CAS No.: 37515-61-0
Purity:  ≥99.0%
Synonyms: Glyceryl palmitoleate
1-Palmitoleoyl glycerol is a biologically active monoacylglycerol. It increases daunomycin accumulation, shown to inhibit P-glycoprotein in Caco-2 cells. 1-Palmitoleoyl glycerol induces thymocyte apoptosis.
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Neotame
Neotame
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Cat. No.: HY-W011053
CAS No.: 165450-17-9
Target:  

Taste Receptor Apoptosis Drug Derivative

Research Areas:  

Metabolic Disease Cancer

Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells [2] .
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Basic green 4
Basic green 4
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Cat. No.: HY-D0203
CAS No.: 569-64-2
Synonyms: Malachite green
Basic green 4 (Malachite green) is a cationic dye that is widely used as a bactericide in aquaculture and is also commonly used in laboratories for the determination of phosphates. Basic green 4 exhibits high cytotoxicity and carcinogenicity to mammalian cells, specifically shown by its IC50 values of 2.03 µM for HEp-2 human laryngeal cells and 13.8 µM for Caco-2 human colorectal adenocarcinoma cells, and it can promote the development of liver tumors. The maximum absorbance wavelength is 621 nm [2] .
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1-Monopalmitin
1-Monopalmitin
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Cat. No.: HY-W009141
CAS No.: 542-44-9
Synonyms: Glyceryl palmitate
Category:  

Plants

Target:  

P-glycoprotein IAP PI3K Akt Caspase Apoptosis

1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC50=50-58 μg/mL), with low toxicity to normal cells [2].
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3-O-Methylgallic acid
3-O-Methylgallic acid
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Cat. No.: HY-N2009
CAS No.: 3934-84-7
Synonyms: 3,4-Dihydroxy-5-methoxybenzoic acid
Category:  

Ketones, Aldehydes, Acids Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

Apoptosis Caspase

3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) is an anthocyanin metabolite and has potent antioxidant capacity. 3-O-methylgallic acid inhibits Caco-2 cell proliferation with an IC50 value of 24.1 μM. 3-O-methylgallic acid also induces cell apoptosis and has anti-cancer effects [2] .
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Dexloxiglumide
Dexloxiglumide
0 Images
Cat. No.: HY-128878
CAS No.: 119817-90-2
Purity:  98.25%
Target:  

Cholecystokinin Receptor P-glycoprotein

Research Areas:  

Metabolic Disease Endocrinology

Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide is the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). Dexloxiglumide exhibits moderate Caco-2 permeability that is polarized, concentration dependent, and pH dependent. Dexloxiglumide increases MRP1-substrate fluorescein uptake. Dexloxiglumide can be studied in research for gastrointestinal diseases and tumors [2] .
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Androgen receptor-IN-6
Androgen receptor-IN-6
0 Images
Cat. No.: HY-155478
CAS No.: 3016437-05-8
Purity:  98.07%
Target:  

Androgen Receptor

Research Areas:  

Cancer

Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC50=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice .
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MAOA-IN-1
MAOA-IN-1
0 Images
Cat. No.: HY-149408
Target:  

Monoamine Oxidase

Research Areas:  

Cancer

MAOA-IN-1 (compound 15) is an orally active MAOA inhibitor with cytotoxicity against prostate cancer cells. MAOA-IN-1 has Caco-2 permeability and lower CNS permeability. MAOA-IN-1 can be further used in the research of anti-cancer and anti-inflammatory indications .
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D-Ala-Lys-AMCA
D-Ala-Lys-AMCA
0 Images
Cat. No.: HY-111956
CAS No.: 375822-19-8
Target:  

Fluorescent Dye

Research Areas:  

Cancer

D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm) [2].
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Carboxymethyl-β-cyclodextrin sodium salt
Carboxymethyl-β-cyclodextrin sodium salt
0 Images
Cat. No.: HY-W1113135
CAS No.: 2828447-14-7
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba 2+, Ca 2+, Cd 2+, Ni 2+, Pb 2+, Sr 2+, and Zn 2+ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research [2] .
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Angelol A
Angelol A
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Cat. No.: HY-N4236
CAS No.: 19625-17-3
Category:  

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