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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Cancer;SLFN12
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Cancer;SLFN12" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-W028690
CAS No.: 328104-79-6
Target:
Research Areas:
DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity .
Cat. No.: HY-N10149
CAS No.: 57103-51-2
Category:
Alkaloids Plant Nauclea officinalis (Pirre ex Pitard) Merr. Extract Indole Alkaloids Rubiaceae Extract
Target:
Cat. No.: HY-153802
CAS No.: 2841750-32-9
Research Areas:
Antitumor agent-100 is an orally active molecular glue that promotes the PDE3A-SLFN12 interaction and induces cell death. Antitumor agent-100 binds to the catalytic pocket of PDE3A, extends hydrophobic groups to mediate the hydrophobic interaction between PDE3A and SLFN12, and stabilizes the PDE3A-SLFN12 complex. Antitumor agent-100 induces cancer cell apoptosis and inhibits tumor growth in mouse xenograft models. Antitumor agent-100 can be used for the research of cervical cancer .
Cat. No.: HY-153802A
CAS No.: 2841750-53-4
Research Areas:
Antitumor agent-100 hydrochloride is an orally active molecular glue that promotes the PDE3A-SLFN12 interaction and induces cell death. Antitumor agent-100 hydrochloride binds to the catalytic pocket of PDE3A, extends hydrophobic groups to mediate the hydrophobic interaction between PDE3A and SLFN12, and stabilizes the PDE3A-SLFN12 complex. Antitumor agent-100 hydrochloride induces cancer cell apoptosis and inhibits tumor growth in mouse xenograft models. Antitumor agent-100 hydrochloride can be used for the research of cervical cancer .
Cat. No.: HY-190259
CAS No.: 2275774-53-1
Research Areas:
PDE3A/B-IN-2 is a PDE3A/B inhibitor that inhibits tumor cell proliferation and modulates the formation of PDE3A-SLFN12 and PDE3B-SLFN12 complexes. PDE3A/B-IN-2 is also a molecular glue. PDE3A/B-IN-2 can be used for cancer research .
Cat. No.: HY-190169
CAS No.: 2841750-38-5
Research Areas:
Antitumor agent-232 is a polycyclic compound derived from Anagrelide (HY-B0523) and also a molecular glue. Antitumor agent-232 modulates the PDE3A/SLFN12 protein interaction. Antitumor agent-232 can be used in cancer research .
Cat. No.: HY-190258
CAS No.: 2275774-47-3
Research Areas:
PDE3A/B-IN-5 is a PDE3A and PDE3B inhibitor with IC50 values of 6 nM and 4 nM, respectively. PDE3A/B-IN-5 is also a molecular glue. PDE3A/SLFN12 stabilizer-1 can be used in research related to cervical cancer and melanoma .
Cat. No.: HY-190257
CAS No.: 2275773-39-0
Research Areas:
PDE3A/B-IN-1 (Example 12) is a PDE3A/B molecular glue inhibitor. PDE3A/B-IN-1 inhibits tumor cell proliferation by inducing and stabilizing the formation of a complex between PDE3A/B and SLFN12 protein. PDE3A/B-IN-1 can be used for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
