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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
91 Results for "
Fc region
" in MedChemExpress (MCE) Product Catalog:
Products (91)
91 Results for "Fc region" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-P99340
CAS No.: 2423014-07-5
Synonyms: VIR-7831 (WT IgG1); GSK-4182136 (WT IgG1)
Sotrovimab (VIR 7831) (WT IgG1) is a human IgG1κ monoclonal antibody targeting the Sarbecovirus subgenus; it is capable of neutralizing SARS-CoV-2, SARS-CoV-1, and various other coronaviruses. Sotrovimab (WT IgG1) retains a native, wild-type Fc region and does not contain the M428L or N434S mutations. Sotrovimab (WT IgG1) can be used for research on COVID-19 .
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3 Cited Publications
Cat. No.: HY-P99355
CAS No.: 1356922-05-8
Synonyms: Anti-ACVR2B Reference Antibody (WT IgG1); BYM338 (WT IgG1)
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Bimagrumab (Anti-ACVR2B Reference Antibody) (WT IgG1) is a human monoclonal antibody that retains a native wild-type Fc region and is capable of blocking the activin type II receptor (ActRII). Bimagrumab (WT IgG1) can be used in research concerning pathological muscle loss and weakness. .
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2 Cited Publications
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2 Cited Publications
Cat. No.: HY-108801
CAS No.: 862111-32-8
Synonyms: VEGF Trap; VEGF-TRAPR1R2; VEGF-trapR1
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Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .
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1 Cited Publications
Cat. No.: HY-P99033
CAS No.: 1905409-39-3
Synonyms: BTCT-4465A; RG-7828; RO7030816
Mosunetuzumab (BTCT-4465A) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs). The Fc region of Mosunetuzumab incorporates a "knob-into-hole" structural modification and an N297G point mutation to achieve heterodimerization and eliminate Fc glycosylation, thereby effectively silencing antibody effector functions .
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1 Cited Publications
Cat. No.: HY-P70771
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGHG4; Immunoglobulin Heavy Constant Gamma 4; Immunoglobulin Heavy Constant Gamma 4 (G4m Marker); Ig Gamma-4 Chain C region; Immunoglobulin Heavy Chain Constant region Gamma 4
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P70705
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FcGR3A; CD16; Prev. FcGR3; Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16); Prev. FcG3; Fc Of IgG Low Affinity IIIa Receptor Isoform 2; FcgammaRIIIa; Fc Of IgG Low Affinity IIIa Receptor Isoform 1; FcGRIIIA; Immunoglobulin G Fc Receptor III; CD16a; Neutrophil-Specific Antigen NA; Low Affinity Immunoglobulin Gamma Fc region Receptor III-A; Fc-Gamma Receptor IIIb (CD16); Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a); Fc Gamma Receptor III-A; Fc Fragment Of IgG Receptor IIIa; Fc-Gamma RIIIa; IgG Fc Receptor III-A; Fc-Gamma RIII; IgG Fc Receptor III-2; FcgammaRIIIA; Fc-Gamma RIII-Alpha; FcRIIIA; CD16a Antigen; FcRIIIa; CD16-II; FcR-10; IGFR3; FcRIII; CD16A; IMD20; Fc Gamma Receptor IIIa; Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment
Species:
Human
Source:
HEK293
Cat. No.: HY-P99391
CAS No.: 1781223-80-0
Synonyms: ABT-700; ABBV-400 Antibody
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Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. The Fc hinge region of Telisotuzumab has been engineered to enhance its rigidity by introducing a new disulfide bond (K222C) and shortening the hinge length (T223del, T225del). Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers .
Cat. No.: HY-P9954
CAS No.: 509077-98-9
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers .
Cat. No.: HY-P99670
CAS No.: 2031153-61-2
Synonyms: CFZ-533 (WT IgG1); OM11-62MF (WT IgG1)
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Iscalimab (WT IgG1) (CFZ-533 (WT IgG1)) is an IgG1 monoclonal antibody that retains a native wild-type Fc region and targets CD40. Iscalimab (WT IgG1) can be used in research concerning Graves' hyperthyroidism and autoimmune diseases .
Cat. No.: HY-P99950
CAS No.: 2484949-51-9
Synonyms: ALX148
Cat. No.: HY-P990735
CAS No.: 2765066-99-5
Synonyms: UCB-1381
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Cat. No.: HY-P99674
CAS No.: 2364496-42-2
Synonyms: GEN3009
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Ivicentamab (GEN-3009) is a bispecific antibody targeting CD37 with dual epitopes. Ivicentamab carries an E430G mutation in the Fc region, which efficiently promotes IgG hexamer formation on the surface of target cells. Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody, enabling it to exert complement-dependent cytotoxicity in Daudi lymphoma cells. Ivicentamab is mainly used in lymphoma-related research .
Cat. No.: HY-P99145A
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Cat. No.: HY-E70884
Synonyms: EndoS2 D184M
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Endoglycosidase S2 (D184M mutant) (EndoS2 D184M) is a mutant endoglycosidase. Endoglycosidase S2 (D184M mutant) promotes the transfer of glyco-oxazoline donors with defined glycoforms to the Fc region of IgG antibodies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
