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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
Kv1.1
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "Kv1.1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P1280
CAS No.: 145808-47-5
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NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels .
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CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl -). CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels .
Cat. No.: HY-P3089A
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Cat. No.: HY-P3055A
Synonyms: DTX-I TFA
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Cat. No.: HY-P2707
CAS No.: 74504-53-3
Synonyms: α-DTX
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Cat. No.: HY-W354851
CAS No.: 67494-15-9
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Bacterial Potassium Channel PPAR Calcineurin Phosphatase Caspase Apoptosis DNA/RNA Synthesis
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Pisiferic acid is a blood-brain barrier-permeable Kv1.1/Kv1.2 opener and Antibacterial agent. Pisiferic acid has no activity against KCNQ2/3, hERG, or Kv2.1. Pisiferic acid inhibits Perilipin1 and PPARγ protein expression. Pisiferic acid activates PP2C, inhibits PP2B/calcineurin, and induces Apoptosis/Caspase-3/7. Pisiferic acid inhibits macromolecule synthesis in Proteus vulgaris and inhibits DNA/lipid/peptidoglycan synthesis in Bacillus subtilis. Pisiferic acid has antibacterial effects against Proteus vulgaris, Staphylococcus aureus, and Bacillus subtilis. Pisiferic acid can be used for research on episodic ataxia type 1, Kv1.2 loss-of-function channelopathy, obesity, and acute promyelocytic leukemia .
Cat. No.: HY-120375
CAS No.: 1821638-40-7
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LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC50 of 35.6 ± 3.2 nM .
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LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research .
Cat. No.: HY-P3055
CAS No.: 107950-33-4
Synonyms: DTX-I
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Cat. No.: HY-126106
CAS No.: 622011-16-9
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(BrMT)2 (compound 2) is a non-peptide snail toxin that slows down the activation of Kv1.1 channels .
Cat. No.: HY-P3089
CAS No.: 119128-61-9
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Cat. No.: HY-P5788
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Cat. No.: HY-P3014
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Cat. No.: HY-P5853
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Cat. No.: HY-P5771
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Cat. No.: HY-P1280A
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Cat. No.: HY-P3316
CAS No.: 183815-75-0
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Cat. No.: HY-P5870
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Cat. No.: HY-P4742A
Synonyms: 6-FAM-AEEAC-SHK TFA
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
