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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
MDM4
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "MDM4" in MCE Product Catalog:
Synonyms: KT7515
Research Areas:
CEP-1347 is an inhibitor of the JNK/SAPK pathway with neuroprotective effects. CEP-1347 blocks JNK1 activation induced by members of the mixed lineage kinase (MLK) family (MLK3, MLK2, MLK1, dual leucine zipper kinase, and leucine zipper kinase). As an inhibitor of MDM4, CEP-1347 can more effectively inhibit the growth of glioma cells expressing wild-type p53 [4] .
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MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12 .
Cat. No.: HY-RS08267
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MDM4 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16923
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Mdm4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdm4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W097753
CAS No.: 834-14-0
Synonyms: 4-Methoxydiphenylmethane
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Research Areas:
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases .
Cat. No.: HY-RS23366
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Research Areas:
Mdm4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mdm4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
0 Images
MDM4-targeting ASO (sodium)
Cat. No.: HY-158830
Cat. No.: HY-158830B
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FAM labled MDM4-targeting ASO sodiumis a FAM labled MDM4-targeting ASO sodium.
Cat. No.: HY-158830C
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Cy3 labled MDM4-targeting ASO sodium is a Cy3 labled MDM4-targeting ASO sodium.
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MDM4-targeting ASO (sodium) scrambled negative control
Cat. No.: HY-158830A
Cat. No.: HY-151170
CAS No.: 3037300-49-2
MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity .
Cat. No.: HY-P74756
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDM4; MDM4 P53 Binding Protein Homolog (Mouse); MDM4 Regulator Of P53; Uncharacterized Protein DKFZp686B01123; MDMX; Uncharacterized Protein DKFZp781B1423; HDMX; MDM4 P53 Binding Protein Homolog; MDM2-Like P53-Binding Protein; P53-Binding Protein MDM4; MD
Species:
Human
Source:
E. coli
Cat. No.: HY-151169
CAS No.: 3037300-57-2
MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity .
Cat. No.: HY-119709
CAS No.: 1353384-61-8
AQ-101 is a MDM2 degrader. Upon binding to MDM2, it blocks the MDM2-MDM4 interaction, inducing autoubiquitination and proteasome-mediated degradation of MDM2. AQ-101 activates p53, upregulates downstream targets including p21 and PUMA, and induces apoptosis and cell cycle arrest in tumor cells. AQ-101 inhibits the progression of acute lymphoblastic leukemia in xenograft animal models. AQ-101 can be used for research related to acute lymphoblastic leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
