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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
Michael-type addition
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "Michael-type addition" in MCE Product Catalog:
Cat. No.: HY-P12385
CAS No.: 526186-99-2
Target:
Research Areas:
HS-MMP-SH is a bis-cysteine matrix metalloproteinase (MMP)-degradable peptide crosslinker that enables cell-mediated degradation of hyaluronic acid hydrogels. HS-MMP-SH undergoes Michael-type addition with acrylate-functionalized hyaluronic acid to form hydrogels. HA-MMP hydrogels crosslinked by HS-MMP-SH support cell infiltration and vascular invasion in vivo .
Cat. No.: HY-P12373
CAS No.: 1620389-76-5
Target:
Research Areas:
CQPQGLAKC is a peptide crosslinker and hydrogel component that can be cleaved by MMP. The degradation of CQPQGLAKC is primarily mediated by endogenous MMP-13, with a Km value of 1.10 µM. CQPQGLAKC crosslinks hyaluronic acid hydrogels via Michael-type addition, thereby enabling cell-mediated matrix remodeling and promoting cell survival, proliferation, and endothelial differentiation. CQPQGLAKC can be used in research on rotator cuff tears and ischemic injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
