RNA splicing | MedChemExpress (MCE) Life Science Reagents

Research Areas:

Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy .

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7

Nusinersen sodium

7 Publications Verification

Cat. No.: HY-112980A

Purity: 98.91%

Target:

Research Areas:

Nusinersen sodium is an antisense oligonucleotide active molecule. Nusinersen sodium modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen sodium improves spinal muscular atrophy .

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3

Thailanstatin A

3 Cited Publications

Cat. No.: HY-129589

CAS No.: 1426953-21-0

Purity: 98.51%

Target:

ADC Payloads

Research Areas:

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC₅₀=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC₅₀s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .

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2

(R)-SKBG-1

2 Cited Publications

Cat. No.: HY-153918

CAS No.: 2955634-67-8

Purity: 99.50%

Target:

Androgen Receptor

Research Areas:

DNA/RNA Synthesis Ras Apoptosis

(R)-SKBG-1 is a covalent inhibitor targeting the RNA binding protein NONO. (R)-SKBG-1 can reduce the expression of androgen receptor (AR) and its splice variants, inhibiting cancer cell proliferation. (R)-SKBG-1 inhibits androgen receptor expression with IC₅₀ of 3.1 μM and 5.5 μM for AR-FL mRNA and AR-V7 mRNA, respectively. (R)-SKBG-1 interferes with the gene regulatory network of cancer cells and inhibits cancer cell growth by stabilizing the interaction between NONO and mRNA. (R)-SKBG-1 can be used in the study of cancers related to NONO dysfunction, such as prostate cancer .

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Oncrasin-1

Cat. No.: HY-16662

CAS No.: 75629-57-1

Target:

Research Areas:

Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer .

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RNA splicing modulator 3

Cat. No.: HY-150248

CAS No.: 2726461-43-2

Purity: 98.58%

Target:

DNA/RNA Synthesis Dystrophin

Research Areas:

Others

RNA splicing modulator 3 is an RNA splicing modulator. RNA splicing modulator 3 modulates nucleic acid splicing, including pre-mRNA splicing .

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Drisapersen

Cat. No.: HY-145724

CAS No.: 1251830-50-8

Purity: 96.05%

Synonyms: Kyndrisa; GSK2402968A; PRO051

Target:

Research Areas:

Drisapersen (Kyndrisa) is a 2 ^'-O-methyl phosphorothioate RNA antisense oligonucleotide that induces exon 51 skipping. Drisapersen induces skipping of exon 51 during Dystrophin pre-mRNA splicing, allowing the synthesis of partially functional Dystrophin. Drisapersen can be used in research related to Duchenne muscular dystrophy .

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PTBP1-RNA-binding inhibitor P6 TFA

Cat. No.: HY-P5960

Synonyms: PTBP1 α3-helix derived peptide P6 TFA

Target:

Research Areas:

PTBP1-RNA-binding inhibitor (PTBP1 α3-helix derived peptide) P6 TFA is a cell-permeable PTBP1 inhibitor. PTBP1-RNA-binding inhibitor P6 TFA binds to the α3 helix binding site of the PTBP1 RRM1 domain, and disrupts the synergistic RNA-binding effect of the RRM1 and RRM2 domains of PTBP1. PTBP1-RNA-binding inhibitor P6 (TFA) regulates the regulatory pattern of PTBP1-related alternative splicing events, and thus exhibits anticancer potential .

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Pararosaniline hydrochloride

Cat. No.: HY-W127770

CAS No.: 569-61-9

Synonyms: Basic red 9

Target:

Fluorescent Dye

Research Areas:

Infection

Pararosaniline hydrochloride (Basic red 9) is a pH-responsive basic dye, as a biological stain to track certain proteins. The pH of the acidified Pararosaniline hydrochloride reagent has a significant effect on the color and the maximum absorption wavelength (λmax) of the reaction system, with its optimum pH 0.48 and a λmax at 549 nm. Pararosaniline hydrochloride is also a strong modifier of RNA splicing. Pararosaniline hydrochloride has been used in the analysis of SO₂ and formaldehyde and staining of bacteria or other organisms. Pararosaniline hydrochloride is extensively used in industries like textile, printing, paper, cosmetic, and leather .

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RNA splicing modulator 1

Cat. No.: HY-150246

CAS No.: 2726461-38-5

Target:

Research Areas:

Others

RNA splicing modulator 1 (compound 233) is a RNA splicing modulator, with an AC₅₀ value of <100 nM .

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Ruxuplam

Cat. No.: HY-177360

CAS No.: 3067915-73-2

Synonyms: RNA splicing modulator-4

Target:

Ruxuplam (RNA splicing modulator-4) is an RNA splicing modulator. Ruxuplam controls the inclusion or exclusion of specific exons in precursor mRNA (pre-mRNA) by regulating alternative splicing events, thereby altering the coding sequence and function of mature mRNA. Ruxuplam shows promise for research into neurodegenerative diseases (such as Huntington's disease) and cancers .

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UHMCP1

Cat. No.: HY-148384

CAS No.: 2103079-87-2

Target:

Fluorescent Dye

Research Areas:

UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a K_d of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties .

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NSC 194308

Cat. No.: HY-153736

CAS No.: 90379-42-3

Purity: 98.40%

Target:

Research Areas:

NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations .

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SMN-C2

Cat. No.: HY-124648

CAS No.: 1446311-56-3

Purity: 98.85%

Target:

Research Areas:

Inflammation/Immunology

SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research .

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ZNL-05-044

Cat. No.: HY-155874

CAS No.: 3034411-38-3

Purity: 99.91%

Target:

CDK

Research Areas:

Methionine Adenosyltransferase (MAT) Histone Methyltransferase

ZNL-05-044 is a CDK11 inhibitor with an IC₅₀s of 0.23 μM and 0.27 μM against CDK11A and CDK11B, respectively (NanoBRET assay). ZNL-05-044 leads to G2/M cell cycle arrest and impairs RNA splicing .

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SCR-7952

Cat. No.: HY-169257

CAS No.: 2798856-04-7

Target:

Research Areas:

SCR-7952 is an orally active MAT2A allosteric inhibitor (IC₅₀ = 18.7 nM; K_i = 14.49 nM; K_d = 0.56 nM). SCR-7952 reduces SAM production, PRMT5 activity, and SDMA marks by binding to the MAT2A allosteric pocket, and dysregulates RNA splicing through FANCA intron retention, thereby selectively inhibiting the proliferation of MTAP-deleted cancer cells and producing synergistic effects with PRMT5 inhibitors. SCR-7952 can be used for research on MTAP-deleted cancers .

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mHTT-IN-2

Cat. No.: HY-156103

CAS No.: 2743336-70-9

Purity: 99.35%

Target:

Huntingtin

Research Areas:

mHTT-IN-2 (compound 27) is a potent inhibitor (EC₅₀=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy .

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7-Methyl-diguanosine triphosphate

Cat. No.: HY-139098

CAS No.: 62828-64-2

Synonyms: m7Gp3G

Target: