35 Results for "

Repression

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "Repression" in MCE Product Catalog:

18
SR8278
SR8278
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18 Publications Verification
Cat. No.: HY-14415
CAS No.: 1254944-66-5
Purity:  99.94%
Target:  

REV-ERB

Research Areas:  

Neurological Disease Metabolic Disease

SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease .
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11
GSK4112
GSK4112
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11 Cited Publications
Cat. No.: HY-14414
CAS No.: 1216744-19-2
Purity:  99.87%
Synonyms: SR6452
Target:  

REV-ERB Apoptosis

Research Areas:  

Metabolic Disease

GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways .
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6
XL177A
XL177A
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6 Cited Publications
Cat. No.: HY-138794
CAS No.: 2417089-74-6
Purity:  99.60%
Target:  

Deubiquitinase Histone Demethylase SARS-CoV

Research Areas:  

Cancer

XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .
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4
BRD-K98645985
BRD-K98645985
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4 Cited Publications
Cat. No.: HY-114268
CAS No.: 1357647-78-9
Purity:  98.42%
Target:  

HIV

Research Areas:  

Infection

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity .
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2
KL044
KL044
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2 Cited Publications
Cat. No.: HY-119506
CAS No.: 1801856-93-8
Purity:  99.05%
Target:  

Cryptochrome

Research Areas:  

Metabolic Disease

KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity .
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2
TL13-112
TL13-112
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2 Cited Publications
Cat. No.: HY-123919
CAS No.: 2229037-19-6
Purity:  98.15%
Target:  

PROTACs Anaplastic lymphoma kinase (ALK) STAT ERK Akt CCR PI3K

Research Areas:  

Cancer

TL13-112 is a ALK PROTAC degrader. TL13-112 degrades the NPM-ALK protein by recruiting the CRBN E3 ligase, thereby blocking oncogenic signal transduction such as STAT3, ERK and AKT, and relieving the transcriptional repression of CD45, CCR7 and PI3Kδ. TL13-112 can be used in related research on anaplastic large cell lymphoma .
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1
CTX1
CTX1
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1 Cited Publications
Cat. No.: HY-U00442
CAS No.: 501935-96-2
Target:  

MDM-2/p53 E1/E2/E3 Enzyme

Research Areas:  

Cancer

CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system .
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1
MS645
MS645
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1 Cited Publications
Cat. No.: HY-125232
CAS No.: 2250091-96-2
Purity:  ≥98.0%
Target:  

Epigenetic Reader Domain

Research Areas:  

Cancer

MS645 is a bivalent BET bromodomains (BrD) inhibitor with a Ki of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells .
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GSK1362
GSK1362
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Cat. No.: HY-176851
CAS No.: 2986733-57-5
Target:  

REV-ERB

Research Areas:  

Inflammation/Immunology

GSK1362 is a selective inverse agonist of REV-ERB. GSK1362disrupts the interaction of REV-ERBα with repressive co-modulators (NCoR1, SMRT2, RIP140). GSK1362 exerts an inverse agonist effect by increasing the transcription of BMAL1 to relieve BMAL1 repression by endogenous REV-ERB ligands. GSK1362 suppresses LPS (HY-D1056)-induced inflammatory cytokine expression, inhibits IL-1β-induced Cxcl5 transcription in cells. GSK1362 can be used for the study of inflammatory diseases .
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Ivospemin
Ivospemin
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Cat. No.: HY-132822
CAS No.: 748119-79-1
Purity:  99.71%
Synonyms: SBP-101
Target:  

Drug Derivative

Research Areas:  

Cancer

Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers .
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N-Acetylmannosamine 6-phosphate sodium salt
N-Acetylmannosamine 6-phosphate sodium salt
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Cat. No.: HY-160821A
CAS No.: 335275-62-2
Synonyms: ManNAc-6P sodium salt
Target:  

Endogenous Metabolite

Research Areas:  

Others

N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy .
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(Rac)-GSK-3484862
(Rac)-GSK-3484862
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Cat. No.: HY-135146A
CAS No.: 2170136-02-2
Purity:  99.43%
Synonyms: GSK3482364
Target:  

DNA Methyltransferase

Research Areas:  

Cancer

(Rac)-GSK-3484862 (GSK3482364) is a selective, orally active, reversible DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 of 0.4 μM. (Rac)-GSK-3484862 inhibits the methyltransferase activity of DNMT1 independently of DNA incorporation, reduces global DNA methylation levels, and relieves the transcriptional repression of HBG1 and HBG2 genes. (Rac)-GSK-3484862 increases fetal hemoglobin levels and the proportion of red blood cells expressing fetal hemoglobin in erythroid progenitor cells and a transgenic mouse model of sickle cell disease. (Rac)-GSK-3484862 can be used in studies related to sickle cell disease .
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KMR-206
KMR-206
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Cat. No.: HY-17663
CAS No.: 2992741-10-1
Target:  

PARP STAT STING IFNAR

Research Areas:  

Cancer

KMR-206 is a PARP7 inhibitor with an IC50 of 13.7 nM. KMR-206 relieves AHR-mediated transcriptional repression and enhances CYP1A1 expression in the presence of TCDD. KMR-206 induces the STING-dependent IFN-β signaling pathway and increases the levels of STAT1, pSTAT1 and nuclear PARP7 in cancer cells. KMR-206 reduces the viability of lung adenocarcinoma cells, enhances radiation-induced immunogenic signals, and induces the production of immunogenic signals in glioblastoma cancer stem cells. KMR-206 destabilizes FRA1 to increase IRF1 levels and promotes the IRF3-CBP/p300 interaction. KMR-206 can be used in studies related to lung adenocarcinoma and glioblastoma .
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Sodium malonate
Sodium malonate
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Cat. No.: HY-W283726
CAS No.: 141-95-7
Target:  

Succinate Dehydrogenase Bacterial Drug Intermediate

Research Areas:  

Infection Metabolic Disease Inflammation/Immunology

Sodium malonate is an inhibitor of succinate dehydrogenase (SDH) and can interfere with the TCA cycle. Sodium malonate can act as an AcrAB‑TolC efflux pump inhibitor, blocking multidrug efflux processes in bacteria and enhancing the efficacy of antibiotics. Sodium malonate can be converted to malonyl‑CoA, which mediates protein lysine malonylation, relieves the transcriptional repression effect of STAT6, upregulates TCF1 protein expression, and thereby promotes CD8 + T cell memory differentiation. Sodium malonate can stimulate ovarian steroidogenesis in immature rats, increasing ovarian and uterine weights and ovarian cholesterol production. Sodium malonate can inhibit brain ATP production, leading to energy deficiency, neuronal glutamate accumulation, and excitotoxic striatal lesions. Sodium malonate can be used in research on metabolism-related diseases, immune-related diseases, and bacterial infections, and can also serve as an intermediate for research related to organic synthesis .
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Leucylproline hydrochloride
Leucylproline hydrochloride
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Cat. No.: HY-W011730
CAS No.: 87178-63-0
Synonyms: Leu-Pro hydrochloride
Target:  

Amino Acid Derivatives Endogenous Metabolite

Research Areas:  

Metabolic Disease

Leucylproline hydrochloride (Leu‑Pro hydrochloride) is a dipeptide composed of L‑leucine and L‑proline, and it is a fecal secondary metabolite associated with the gut microbiota. Leucylproline hydrochloride is taken up by Lactococcus lactis cells via the di‑tripeptide transport system, and mediates transcriptional repression of the prtP/prtM promoter after intracellular accumulation. The content of Leucylproline hydrochloride is significantly decreased in fecal samples related to hepatolenticular degeneration. Leucylproline hydrochloride can be used for the study of metabolism‑related diseases .
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m-Carboxycinnamic acid bishydroxamide
m-Carboxycinnamic acid bishydroxamide
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Cat. No.: HY-W014004
CAS No.: 174664-65-4
Synonyms: CBHA
Target:  

HDAC Apoptosis

Research Areas:  

Others Cancer

m-Carboxycinnamic acid bishydroxamide (CBHA) is a histone deacetylase inhibitor. m-Carboxycinnamic acid bishydroxamide modulates histone acetylation sites, alters DNA methylation and epigenetic status, increases global histone acetylation, alleviates transcription repression, and facilitates chromatin remodelling. m-Carboxycinnamic acid bishydroxamide can be used for the research of cloned embryo development and epigenetic regulation .
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Leucylproline
Leucylproline
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Cat. No.: HY-114729
CAS No.: 6403-35-6
Synonyms: Leu-Pro
Target:  

Amino Acid Derivatives Endogenous Metabolite

Research Areas:  

Metabolic Disease

Leucylproline (Leu‑Pro) is a dipeptide composed of L‑leucine and L‑proline, and it is a fecal secondary metabolite associated with the gut microbiota. Leucylproline is taken up by Lactococcus lactis cells via the di‑tripeptide transport system, and mediates transcriptional repression of the prtP/prtM promoter after intracellular accumulation. The content of leucylproline is significantly decreased in fecal samples related to hepatolenticular degeneration. Leucylproline can be used for the study of metabolism‑related diseases .
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(Rac)-XL177A
(Rac)-XL177A
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Cat. No.: HY-138794A
CAS No.: 2417089-73-5
Target:  

Deubiquitinase

Research Areas:  

Cancer

(Rac)-XL177A is the racemic isomer of XL177A (HY-138794). XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .
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Kihadanin B
Kihadanin B
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Cat. No.: HY-122959
CAS No.: 73793-68-7
Category:  

Rutaceae Extract Other Terpenoids 500 - Internal Server Error | MedChemExpress

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